Property Comparison of Transition‐Metal Dichalcogenides (MoS₂, MoSe₂ and MoTe₂) and Their Applicability as Electrochemical Biosensors for Glucose Detection

Abstract

Two-dimensional transition-metal dichalcogenides (TMDs) have attracted widespread interests owing to their attractive physical and chemical properties. In particular, they are especially attractive in the field of electrochemical biosensors. In this study, the properties of TMDs ((molybdenum sulfide (MoS 2 ), molybdenum diselenide (MoSe 2 ) and molybdenum telluride (MoTe 2 )) on the glucose sensing were explored and compared. Exfoliated MoS 2 , MoSe 2 and MoTe 2 nanosheets with basically the same size were fabricated through controlling the ultrasonic power. The structure and morphological characteristics of MoS 2 , MoSe 2 and MoTe 2 were examined through scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and powder X-ray diffractometer.Electrochemical properties were analyzed through cyclic voltammetry and differential pulse voltammetry. Results showed that all the three kinds of TMDs can enhance the electroconductibility of the electrodes. When incorporated into the construction of electrochemical biosensors for glucose detection, all of the three kinds of exfoliated TMDs modified electrodes possessed achieved analytical requirements of selectivity, wide linear ranges, as well as low limits of detection and quantification. In particular, MoS 2 -based biosensor generated a higher specificity and lower detection limit than that of MoSe 2 and MoTe 2 . This is imperative to showcase the real potential of TMDs in electrochemical biosensors.

Recent Progress in Transition Metal Dichalcogenides for Electrochemical Biomolecular Detection

“…MoS 2 is widely reported for the detection of glucose in the absence [45] and presence [40] of redox molecules (Figure 5A,B). The detection of cholesterol, an important small molecule associated with cardiovascular disease, has also attracted considerable attention in TMD sensor research.…”

“…Utilization of TMDs for small molecules using electrochemical detection methods of glucose (A) re-printed from ref. [45], (B) ref. [40], and cholesterol (C) ref.…”

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS2 Nanosheet-Modified Molecularly Imprinted Biopolymer

“…Various nanomaterials have been explored for improving the overall performance of MIP-based sensors such as nanosheets, nanotubes, nanoparticles, etc. Among them, transition metal dichalcogenide (TMDC) 2D nanosheets, such as MoS 2 , MoSe 2 , WS 2 , etc., have shown tremendous ability in enhancing the sensitivity, stability, and linear detection range of the electrochemical sensor due to their size, shape, and dimensionality. − They have stacked layers harboring intercalated metal atoms between the two hexagonal chalcogen layers via a covalent bond. They offer faster heterogeneous electron movement across the electrolyte and electrode surface and show excellent tuning of the band gap. , Thus, TMDC 2D nanosheets stand out among various other nanomaterials for biosensor and biomedical applications.…”

MoTe2 Field-Effect Transistor for the Rapid Detection of Streptavidin via Engineered Support Construct

“…Particularly, in recent research projects related to biosensor applications, molybdenum ditelluride (MoTe 2 ) has been utilized for DNA detection 23 and glucose detection. 24 Here, a few layers of thin MoTe 2 flakes were used to fabricate 2D-FET biosensors for the detection of the streptavidin protein.…”

“…However, due to low-Fermi-level pinning and moderate band gap, molybdenum ditelluride (α-MoTe 2 )-based devices have received significant scientific attention for electronic and optoelectronics applications. Particularly, in recent research projects related to biosensor applications, molybdenum ditelluride (MoTe 2 ) has been utilized for DNA detection and glucose detection …”