Property changes of urinary nanocrystallites and urine of uric acid stone formers after taking potassium citrate

Zhang, Guang-Na; Ouyang, Jing; Xue, Jun-Fa; Shang, Yun-Feng

doi:10.1016/j.msec.2013.05.049

Cited by 12 publications

(20 citation statements)

References 24 publications

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“…Moreover, the same methods and drugs are used in uroliths without distinction. Consequently, curative effects and lower cured rates differ [1,2]. MAP, the most common component of alkaline stones, contains MAP hexahydrate (struvite, MgNH 4 PO 4 ⋅6H 2 O) and magnesium hydrogen phosphate trihydrate (newberyite, MgHPO 4 ⋅3H 2 O).…”

Section: Introductionmentioning

confidence: 99%

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Formation Mechanism of Magnesium Ammonium Phosphate Stones: A Component Analysis of Urinary Nanocrystallites

Sun

Ouyang

Wang

et al. 2015

Journal of Nanomaterials

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The components of urinary nanocrystallites in patients with magnesium ammonium phosphate (MAP) stones were analyzed by X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectrometer, high-resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED), fast Fourier transformation (FFT), and energy-dispersive X-ray spectroscopy (EDS). The main components of the stones were MAP hexahydrate (MAP⋅6H 2 O), magnesium hydrogen phosphate trihydrate (MgHPO 4 ⋅3H 2 O), and a small amount of calcium phosphate (CaP), while the main components of urinary nanocrystallites were MgHPO 4 ⋅3H 2 O, CaP, and MAP monohydrate (MAP⋅H 2 O). MAP⋅H 2 O induced the formation of MAP stones as seed crystals. MgHPO 4 ⋅3H 2 O was accompanied by the appearance of MAP⋅6H 2 O. The formation mechanism of MAP stones and influencing factors were discussed on the basis of the components of urine nanocrystallites. A model diagram of MAP stone formation was also put forward based on the results. Formation of MAP stones was closely related to the presence of high amounts of MAP crystallites in urine. Urinary crystallite condition and changes in urine components could indicate the activity of stone diseases.

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Section: Introductionmentioning

confidence: 99%

“…The conditions of urinary crystals are closely related to stone formation [1,2,[5][6][7][8][9][10]. On the one hand, the disappearance of specific types of urinary crystallites in urine (e.g., cystine and struvite) demonstrates a recurring trend of reduction in stone formation.…”

Section: Introductionmentioning

confidence: 99%

Formation Mechanism of Magnesium Ammonium Phosphate Stones: A Component Analysis of Urinary Nanocrystallites

Sun

Ouyang

Wang

et al. 2015

Journal of Nanomaterials

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“…Therefore, the conditions of urinary crystal formation are closely related to those of urolithiasis [5,6]. On one hand, the disappearance of specific types of urinary crystallites in urine (e.g., cystine and struvite) demonstrates a recurring trend of reduction in stone formation.…”

Section: Introductionmentioning

confidence: 99%

Components of Urinary Crystallites in 56 Cases of Patients with Magnesium Ammonium Phosphate Stones

Gan¹,

Ouyang²

2015

Proceedings of the International Conference on Chemical, Material and Food Engineering

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“…Therefore, several studies [7][8][9] believed that urolithiasis was more accurate to be predicted by crystalluria than 24 h urine volume or calcium excretion and even more accurate than urinary calcium and urinary oxalate concentration. Different sizes of urinary crystallites have been observed, such as crystallites with a size of 1 nm to 1000 nm [6,[10][11][12][13] and that more than tens of microns [14,15]. However, whether the effect of these different sizes of urinary crystallites on urinary stone formation differs or not remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Physicochemical Properties of Nano‐ and Microsized Crystals in the Urine of Calcium Oxalate Stone Patients and Control Subjects

Gao

Xue

et al. 2014

Journal of Nanomaterials

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Purpose. To compare the properties of different sizes of urinary crystallites between calcium oxalate (CaOx) calculi patients and healthy controls. Methods. We studied the average particle size, size distribution, intensity-autocorrelation curve, zeta potential ( ), conductivity, mobility, aggregation state, and stability of different sizes of urinary crystallites by nanoparticle size analysis and transmission electron microscopy after filtration through a microporous membrane with an aperture size from 0.22 m to 0.45, 1.2, 3, and 10 m. Results. The urinary crystallites of the CaOx calculi patients were uneven and much easy to aggregate than those of controls. The number of large-sized crystallites of the patients was significantly more than that of the controls. The main components of the nanosized urinary crystallites in patients were CaOx monohydrate (COM), uric acid, and -calcium phosphate, and these components were basically similar to those of the microsized urinary crystallites. The urinary crystallites of the calculi patients were easier to aggregate than that of the controls, and the small-sized urinary crystallites were much easier to agglomerate. Conclusions. The urinary system of CaOx calculi patients is unstable and highly susceptible to urinary crystallite aggregation. The rapid aggregation of urinary crystallites may be the key factor affecting urolithiasis formation.

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Property changes of urinary nanocrystallites and urine of uric acid stone formers after taking potassium citrate

Cited by 12 publications

References 24 publications

Formation Mechanism of Magnesium Ammonium Phosphate Stones: A Component Analysis of Urinary Nanocrystallites

Formation Mechanism of Magnesium Ammonium Phosphate Stones: A Component Analysis of Urinary Nanocrystallites

Components of Urinary Crystallites in 56 Cases of Patients with Magnesium Ammonium Phosphate Stones

Comparison of Physicochemical Properties of Nano‐ and Microsized Crystals in the Urine of Calcium Oxalate Stone Patients and Control Subjects

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