Properties, synthesis, characterization and application of hydrogel and magnetic hydrogels: A concise review

Fernandes, Renan da Silva; Tanaka, Fabrício Nunes; Angelotti, Arthur Maffei; Júnior, Carlos Roberto Ferreira; Yonezawa, Uilian Gabaldi; Filho, Adhemar Watanuki; Moura, Márcia R. de; Aouada, Fauze A.

doi:10.1016/b978-0-12-820092-6.00017-3

Cited by 5 publications

(4 citation statements)

References 89 publications

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“…Hydrogels can be classified based on several properties ( Figure 2 ), which will be discussed in detail below. Classification can depend on the properties of the hydrogel such as biocompatibility, swellability, and stimulus sensitivity, which depend on how the hydrogel is synthesized ( Figure 2 ) [ 3 , 10 , 17 , 18 ]. They can be categorized based on their ionic charge, where the charge of the hydrogel network depends on the individual polymer charges and may be a net positive, negative, or neutral [ 10 , 19 ].…”

Section: Overview Of Hydrogelsmentioning

confidence: 99%

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges

Wu,

Akbar,

Giunta

et al. 2023

Materials

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The human eye’s intricate anatomical and physiological design necessitates tailored approaches for managing ocular diseases. Recent advancements in ophthalmology underscore the potential of hydrogels as a versatile therapeutic tool, owing to their biocompatibility, adaptability, and customizability. This review offers an exploration of hydrogel applications in ophthalmology over the past five years. Emphasis is placed on their role in optimized drug delivery for the posterior segment and advancements in intraocular lens technology. Hydrogels demonstrate the capacity for targeted, controlled, and sustained drug release in the posterior segment of the eye, potentially minimizing invasive interventions and enhancing patient outcomes. Furthermore, in intraocular lens domains, hydrogels showcase potential in post-operative drug delivery, disease sensing, and improved biocompatibility. However, while their promise is immense, most hydrogel-based studies remain preclinical, necessitating rigorous clinical evaluations. Patient-specific factors, potential complications, and the current nascent stage of research should inform their clinical application. In essence, the incorporation of hydrogels into ocular therapeutics represents a seminal convergence of material science and medicine, heralding advancements in patient-centric care within ophthalmology.

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Section: Overview Of Hydrogelsmentioning

confidence: 99%

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges

Wu,

Akbar,

Giunta

et al. 2023

Materials

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“…However, these approaches can be limited by difficulties in nanoparticle dispersion in the polymerization medium and agglomeration occurring during gel formation. , In contrast, physical mixing is a relatively simple and straightforward approach to prepare magnetic hydrogels . In this process, dispersed MNPs become physically trapped within the hydrogel matrix during the gelation process . For instance, Zhang et al reported a superparamagnetic iron oxide nanoparticle (SPION)-loaded nanocapsule hydrogel system for multiple magnetic hyperthermia therapy and long-term magnetic resonance imaging contrast via simply physically mixing poly(organophosphazene) and as-synthesized SPIONs.…”

Section: Introductionmentioning

confidence: 99%

“… 21 In this process, dispersed MNPs become physically trapped within the hydrogel matrix during the gelation process. 22 For instance, Zhang et al 23 reported a superparamagnetic iron oxide nanoparticle (SPION)-loaded nanocapsule hydrogel system for multiple magnetic hyperthermia therapy and long-term magnetic resonance imaging contrast via simply physically mixing poly(organophosphazene) and as-synthesized SPIONs. However, gels formed by physical mixing typically have no strong covalent or chemical bonds between the MNPs and the hydrogel network.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Self-Assembled Block Copolymer/Iron Oxide Nanocomposite Hydrogels Formed from Wormlike Micelles

Yue,

Wang,

Jones

et al. 2024

ACS Appl. Mater. Interfaces

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This article reports the preparation of multifunctional magnetic nanocomposite hydrogels formed from wormlike micelles. Specifically, iron oxide nanoparticles were incorporated into a temperature responsive block copolymer, poly(glycerol monomethacrylate)-b-poly(2-hydroxypropyl methacrylate) (PGMA-b-PHPMA), and graphene oxide (GO) dispersion at a low temperature (∼2 °C) through high-speed mixing and returning the mixture to room temperature, resulting in the formation of nanocomposite gels. The optimal concentrations of iron oxide and GO enhanced the gel strength of the nanocomposite gels, which exhibited a strong magnetic response when a magnetic field was applied. These materials retained the thermoresponsiveness of the PGMA–PHPMA wormlike micelles allowing for a solid-to-liquid transition to occur when the temperature was reduced. The mechanical and rheological properties and performance of the nanocomposite gels were demonstrated to be adjustable, making them suitable for a wide range of potential applications. These nanocomposite worm gels were demonstrated to be relatively adhesive and to act as strain and temperature sensors, with the measured electrical resistance of the nanocomposite gels changing with applied strain and temperature sweeps. The nanocomposite gels were found to recover efficiently after the application of high shear with approximately 100% healing efficiency within seconds. Additionally, these nanocomposite worm gels were injectable, and the addition of GO and iron oxide nanomaterials seemed to have no significant adverse impact on the biocompatibility of the copolymer gels, making them suitable not only for 3D printing in nanocomposite engineering but also for potential utilization in various biomedical applications as an injectable magnetic responsive hydrogel.

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“…These polymers are composed of chemically, functionally, and morphologically distinct blocks, including natural, synthetic raw materials or nano/microstructures interconnected via physical or chemical means. They have been developed to improve existing formulations and to expand their range of applications [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Application and Effect of Hybrid Nanocomposites Based on Hydrogel and Nanoclay in Cement-Mortars

et al. 2022

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Hybrid nanocomposite hydrogels, as admixtures for internal curing of cementitious materials, have been widely studied. This study analyzes the effect of applying 0.5% (wt/wt cement) of pre-soaked hydrogels based on polyacrylamide, carboxymethylcellulose, and three different concentrations of Cloisite-Na+ (0, 10, and 20% wt/wt) on the fresh and hardened properties of cementitious mortars. In general, all mortars with hydrogel decreased the consistency index, mainly M20, due to the high concentration of Cloisite-Na+ that modifies the release kinect of the hydrogel. The results showed a slight variation, with an overall average value of 99% water retention in all mortars. This behavior is due to the portion of hydrogel-mortars dosage water retained to reduce the availability of free water in the mixture because this amount of water is stored, a priori, within the polymer particles. At 28 d, the mortars produced with hydrogels containing 20% of nanoclay (M20) exhibit mechanical behavior similar to the reference mortar (M), which corroborates the percentage of voids found. Scanning electron microscope images confirm that the M and M20 mortars are uniform and possess few pores or microcracks. Thus, these hybrid hydrogels have the potential to be innovative materials for water control improvements in cementitious materials technology.

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Properties, synthesis, characterization and application of hydrogel and magnetic hydrogels: A concise review

Cited by 5 publications

References 89 publications

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges

Multifunctional Self-Assembled Block Copolymer/Iron Oxide Nanocomposite Hydrogels Formed from Wormlike Micelles

Synthesis, Application and Effect of Hybrid Nanocomposites Based on Hydrogel and Nanoclay in Cement-Mortars

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