Properties of Young Erythrocytes in Relation to Agglutination and Their Behavior in Hemorrhage and Transfusion

Survival of Preserved Erythrocytes After Transfusion.

“…Nor has any attempt been made in these experiments to correlate the increased counts with the reticulocyte count. That new cells, because of the immaturity of their agglutinogens, may be nonagglutinable and therefore be included in the free-cell count, as suggested by Isaacs,22 is unlikely in view of the observations of Mollison and Young. 5 The reappearance of donor cells after the curve reaches the base-line as in curves 6,16, and 17 appears to be authentic, since this is suggested also by the results of other workers.3…”

The Direct Coombs Test and Reticulocytes*

“…Variations in the non-agglutinable cell fraction which occur in performing the Ashby test for erythrocyte life-span have been attributed to the varying numbers of reticulocytes, and it was assumed that the reticulocyte was not agglutinated by anti-A or anti-B sera, as was the erythrocyte (Isaacs, 1924). The alteration in cellular A and B agglutinogens, as a function of the erythrocyte immaturity, was also reported and the data indicated that the agglutinogens were absent in Type I, but were present in Types 111 and IV, and present to an intermediate degree in Type I1 cells (Sievers, 1942).…”

The Relation of Anaphylactic Disturbances to Arthritis

“…Following influenza, and, in one patient, after a tonsillectomy, sugar tolerance greatly decreased, a fact that he attributed to the presence of infection, which, in the postoperative case, was probably the relighting of an old focus. Scrutiny of the regular food intake of these patients revealed "excess of carbo¬ hydrate food," but "the addition of food rich in vita¬ min" was by no means always effective in relieving the arthritis, and this author was not able to hit on any 1 satisfactory explanation of the fact that restriction in diet was of so much benefit to some, and wholly ineffec¬ tive with others, apparently presenting identical condi¬ tions. I am of the opinion that the application of the food allergy test would have made the whole situation perfectly clear.…”