Properties of the amphiphilic films in mixed cationic/anionic vesicles: a comprehensive view from a literature analysis

Tondre, C.; Caillet, Céline

doi:10.1016/s0001-8686(00)00081-6

Cited by 273 publications

(243 citation statements)

References 73 publications

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“…In mixed cationic/anionic surfactant systems, the headgroup repulsions are weakened due to the presence of opposite charges, leading to much smaller headgroup areas per molecule, whereas the chain cross section areas remain relatively unchanged. Thus, the average effective CPP value (CPP eff ) per surfactant for the catanionic mixture is expected to increase, originating an interface with lower curvature [9,15]. Mixtures with a composition closer to equimolarity have a CPP eff approaching 1 and hence a tendency to form bilayer structures (such as vesicles), instead of micelles that have a much higher hemolytic potential toward cell membranes.…”

Section: Hemolytic Activitymentioning

confidence: 99%

“…In this respect, the results imply that toxicity should not be an obstacle for their potential use. In addition, one should bear in mind that these vesicles show the superior advantages of being spontaneously formed and having long-term stability (owing to their likely thermodynamic stability), in contrast to classic lipid liposomes [9,10,12,15,63].…”

Section: Overviewmentioning

confidence: 99%

“…see reviews [10,11]). In this context, mixtures of oppositely charged surfactants have emerged in the last 10-15 years as an exciting new class of vesicle-forming systems (catanionic vesicles), as described further [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, results are also presented here for novel catanionic vesicles prepared from 12Lys12/DTAB [24] and 12Lys12/12Ser [25] mixtures. From a colloidal standpoint, catanionic vesicles bear several advantages as compared to conventional liposomes: (i) they form spontaneously upon mixing of individual co-solute micellar solutions, requiring no high-energy methods; (ii) they have long-term stability and in many cases exist as equilibrium structures (thus, indefinitely stable); (iii) they often present chain melting transitions well below room temperature; (iv) they offer the possibility of charge regulation, due to variation of the surfactant mixing ratio [9,[12][13][14][15]26,27].…”

Section: Introductionmentioning

confidence: 99%

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Physicochemical and toxicological properties of novel amino acid-based amphiphiles and their spontaneously formed catanionic vesicles

Brito

Marques

Silva

et al. 2009

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tThe design of efficient liposomal systems for drug delivery is of considerable biomedical interest. In this context, vesicles prepared from cationic/anionic surfactants may offer several advantages, mainly due to their spontaneity in formation and long-term stability. There is also an impending need to produce less toxic, more biocompatible amphiphiles, while maintaining the desirable aggregation properties. In this work, we present data for acute toxicity to Daphnia magna (IC 50 ), and potential ocular irritation (HC 50 ) for some newly prepared ionic surfactants with dodecyl chains, derived from the amino acids tyrosine (Tyr), serine (Ser), hydroxyproline (Hyp) and lysine (Lys). The micellization behavior of the compounds, evaluated from surface tension measurements, is presented and compared to more conventional ionic amphiphiles. Two types of spontaneouly formed catanionic vesicles, composed either by a dodecyltrimethylammonium bromide (DTAB)/Lys-derivative and or Ser-/Lys-derivative mixture, have also been tested for their ecotoxicity and hemolytic potential. All the micelle-forming surfactants as well as the vesicle-containing mixtures are found to have lower ecotoxicity than the reference surfactant DTAB. Moreover, the results from hemolysis and hemoglobin denaturation tests show that the Tyr-and Lys-derivatives are moderately irritant, whereas the Hyp-and Ser-ones are just slightly irritant. Even more significantly, the vesicle-containing mixtures exhibit lower hemolytic activity than the neat surfactants, a positive result for their potential use in liposomal formulations.

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Section: Hemolytic Activitymentioning

confidence: 99%

Section: Overviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Physicochemical and toxicological properties of novel amino acid-based amphiphiles and their spontaneously formed catanionic vesicles

Brito

Marques

Silva

et al. 2009

Colloids and Surfaces B: Biointerfaces

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“…Among others, the list includes micelles, vesicles, swollen lamellar phases, and flat nanodisks, whose linear dimensions may extend up to several hundreds of nanometers. [3][4][5][6][7] All these self-assembled structures exhibit properties well differentiated from those observed in much simpler, i.e., one component, surfactant solutions. These distinctive features, in turn, are manifested in larger absorptions, unusually strong surface activity, and shifts in the critical micellar concentrations, to quote just a few important examples.…”

Section: Introductionmentioning

confidence: 99%

Computer simulations of catanionic surfactants adsorbed at air/water interfaces. II. Full coverage

Clavero

Rodríguez

Laría

2007

The Journal of Chemical Physics

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We extend our previous molecular dynamics experiments ͓Rodriguez et al., J. Phys. Chem. B 109, 24427 ͑2005͔͒ to the analysis of the adsorption of catanionic surfactants at water/air interfaces, at a surfactant coverage close to that of the saturated monolayer: 30.3 Å 2 per headgroup. The mixture of surfactants investigated corresponds to equal amounts of dodecytrimethylammonium ͑DTA͒ and dodecylsulfate ͑DS͒. The structure of the interface is analyzed in terms of the local densities and orientational correlations of all relevant interfacial species. In accordance with experimental evidence, the DTA headgroups penetrate deeper into the aqueous substrate than the DS ones, although the average positions of all headgroups, with respect to the interface, lie in positions somewhat more external than the ones observed at lower coverages. Average tail tilts are close to 45°. The characteristics of the headgroup-water substrate correlations are also analyzed using a tessellation procedure of the interface. The density and polarization responses of the interfacial domains closest to the DS headgroups are enhanced, compared to those adjacent to the DTA detergents. Dynamical aspects related to the diffusion and to the orientational correlations of different water layers in close contact with the surfactant are also investigated.

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Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes

et al. 2022

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Lipid-like ion-pair amphiphile vesicles, or catanionic vesicles, have emerged as potential drug carriers. The effects of cholesterol on the properties of catanionic vesicles have yet been systematically studied. Here, we compared the effects of cholesterol on the structures and fluidities of dipalmitoylphosphatidylcholine liposomes and catanionic vesicles with similar main transition temperatures (T m ). For liposomes, fluorescence anisotropy (FA) thermograms reveal typical condensing and disordering effects of cholesterol above and below T m respectively. In contrast, FA and molecular simulation data reveal that catanionic bilayers below T m are more fluidic due to shorter alkyl chains. This leads to only condensing effects of cholesterol for catanionic vesicles at all temperatures. Our results provide important insights into the fabrication of catanionic vesicles as novel drug carriers.

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Properties of the amphiphilic films in mixed cationic/anionic vesicles: a comprehensive view from a literature analysis

Cited by 273 publications

References 73 publications

Physicochemical and toxicological properties of novel amino acid-based amphiphiles and their spontaneously formed catanionic vesicles

Physicochemical and toxicological properties of novel amino acid-based amphiphiles and their spontaneously formed catanionic vesicles

Computer simulations of catanionic surfactants adsorbed at air/water interfaces. II. Full coverage

Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes

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