Properties of solid dispersions of piroxicam in polyvinylpyrrolidone K-30

Tantishaiyakul, Vimon; Kaewnopparat, Nattha; Ingkatawornwong, Suthimaln

doi:10.1016/s0378-5173(96)04687-x

Cited by 97 publications

(49 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Fig. 7, all binary solid dispersions, ITSDs, and ETSDs showed an absence of the characteristic melting endotherm of sulfathiazole, confirming a solid solution of an amorphous form of sulfathiazole dispersed in the polymeric porous carrier matrix at the molecular level (25)(26)(27). While preparing the PM, a partial disorientation of the organized crystalline structure of sulfathiazole occurs due to the size reduction, which partially disrupts the crystalline structure (28,29).…”

Section: Modulated Differential Scanning Calorimetrymentioning

confidence: 76%

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

Patel¹,

Dave²

2013

AAPS PharmSciTech

View full text Add to dashboard Cite

Abstract. Colloidal solid dispersion is an innovative breakthrough in the pharmaceutical industry that overcomes the solubility-related issue of poorly soluble drugs by using an amorphous approach and also the stability-related issue by means of a complex formation phenomenon using different carrier materials. In the present study, a newly developed adsorption method is introduced to incorporate a high-energy sulfathiazole-polyvinylpyrrolidone (Plasdone® K-29/32) solid dispersion on porous silicon dioxide (Syloid® 244FP). Different ternary systems of sulfathiazole-Plasdone® K-29/32-Syloid® 244FP were prepared (1:1:2, 1:1:3, and 1:2:2) and categorized depending on the mechanism by which Syloid® 244FP was incorporated. Modulated differential scanning calorimetry (MDSC), X-ray diffraction, Fourier transform infrared spectroscopy, and in vitro dissolution studies were conducted to characterize the ternary systems. The X-ray diffraction and MDSC data showed a lack of crystallinity in all internal and external ternary systems, suggesting a loss of the crystallinity of sulfathiazole compared to the physical mixtures. USP apparatus II was used to measure the in vitro dissolution rate of the prepared systems at 75 rpm in different media. The dissolution rate of the optimum ratio (1:2:2) containing an internal ternary solid dispersion system was found to be three times higher than that of the external and physical systems. Thus, the porous silicon dioxide incorporated into the conventional binary solid dispersion acted as a carrier to disperse the complex and increase the dissolution rate.

show abstract

Section: Modulated Differential Scanning Calorimetrymentioning

confidence: 76%

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

Patel¹,

Dave²

2013

AAPS PharmSciTech

View full text Add to dashboard Cite

show abstract

“…Crystallization process is also affected by the choice of additives (4,8,11,12). Addition of PEG 4000 and PVP K30 during recrystallization influenced the dissolution rate.…”

Section: Solubility and Dissolution Studiesmentioning

confidence: 99%

“…However, recrystallized piroxicam displayed a better dissolution profile than the untreated form of piroxicam. The differences are due to the use of water-soluble hydrophilic polymers (4,8) forming a hydrophilic film on the surface of drug crystals, increasing the drug wettability and preventing drug aggregation, changing the crystallinity of piroxicam and giving rise to a form with a better dissolution rate (4,11,10,13).The presence of additives during the crystallization process might also cause a defect in the crystal structure and the crystal would become thermodynamically unstable and hence dissolve faster.…”

mentioning

confidence: 99%

Crystal modifications and dissolution rate of piroxicam

Lyn¹,

Sze²,

Rajendran³

et al. 2011

Acta Pharmaceutica

View full text Add to dashboard Cite

Crystal modifications and dissolution rate of piroxicam Piroxicam is a nonsteroidal anti-inflammatory drug with low aqueous solubility which exhibits polymorphism. The present study was carried out to develop polymorphs of piroxicam with enhanced solubility and dissolution rate by the crystal modification technique using different solvent mixtures prepared with PEG 4000 and PVP K30. Physicochemical characteristics of the modified crystal forms of piroxicam were investigated by X-ray powder diffractometry, FT-IR spectrophotometry and differential scanning calorimetry. Dissolution and solubility profiles of each modified crystal form were studied and compared with pure piroxicam. Solvent evaporation method (method I) produced both needle and cubic shaped crystals. Slow crystallization from ethanol with addition of PEG 4000 or PVP K30 at room temperature (method II) produced cubic crystal forms. Needle forms produced by method I improved dissolution but not solubility. Cubic crystals produced by method I had a dissolution profile similar to that of untreated piroxicam but showed better solubility than untreated piroxicam. Cubic shaped crystals produced by method II showed improved dissolution, without a significant change in solubility. Based on the XRPD results, modified piroxicam crystals obtained by method I from acetone/benzene were cube shaped, which correlates well with the FTIR spectrum; modified needle forms obtained from ethanol/methanol and ethanol/acetone showed a slight shift of FTIR peak that may be attributed to differences in the internal structure or conformation.

show abstract

“…Solid dispersions prepared with high proportions of PVP tend to exhibit higher drug solubility and release rate than those with high proportions of drug [2].…”

Section: Preparation Of the Solid Dispersionsmentioning

confidence: 99%

“…Hydrophilic polymers have been widely investigated as carrier substances for solid dispersions and its high molecular size of the polymers favours the formation of solid solutions. MB is a highly effective broad-spectrum antihelmintic indicated for the treatment of nematode infestations and the PVP K30 is a hydrophilic polymer widely employed as a carrier for preparing solid dispersions [2] due to its high aqueous solubility, excellent biocompatibility with tissues and its low toxicity [3], it was used in precise ratio (drug to carrier ratio).…”

mentioning

confidence: 99%

Physicochemical Characterization and Solubility Enhancement Studies of Mebendazole Solid Dispersions in Solvent Mixtures

Ángeles¹,

Escalera²,

Pena-Fernandez³

et al. 2016

JPP

View full text Add to dashboard Cite

Abstract:The objective was to obtain solid dispersion to improve the dissolution rate, solubility and oral absorption of MB (mebendazole), poor water-soluble drugs. The new formulation was characterized by DSC (differential scanning calorimetry), PXRD (powder X-ray diffraction), FT-IR (fourier transform infrared spectroscopy) and STEM (scanning transmission electron microscopy) methods. Solid dispersions of MB with polyvinylpyrrolidone K-30 (PVP K30) were prepared by solvent evaporation method. The solubility of MB (original powder) and that of the solid dispersions was measured at 25ºC in ethanol-water. The aqueous solubility of MB was favoured by the presence of the polymer in solvent mixtures. Combination of solid dispersions with co-solvents increased the water solubility of MB in a larger extent that each method separately. Solubility parameter () was used to relate to solubility profiles. MB and the solid dispersions show a solubility curve with a single peak at ı = 30.78 MPa 1/2 . Solid state characterizations indicated that the solid dispersion exist an amorphous material entrapped in polymer matrix getting highest improvement in wettability and solubility.

show abstract

Properties of solid dispersions of piroxicam in polyvinylpyrrolidone K-30

Cited by 97 publications

References 8 publications

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

Crystal modifications and dissolution rate of piroxicam

Physicochemical Characterization and Solubility Enhancement Studies of Mebendazole Solid Dispersions in Solvent Mixtures

Contact Info

Product

Resources

About