Properties of skin stem cells and their potential clinical applications in modern dermatology

Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review

“…Each of these stem cell types expresses different markers. 26,27 Although S-MSCs are able to differentiate into neurons, from a functional point of view, these cells present an immature electrophysiological profile. 27 The implantation of S-MSCs into an adult mouse brain led to the discovery that these cells are capable of differentiating into astrocytes as well as insulinproducing pancreatic cells.…”

“…26,27 Although S-MSCs are able to differentiate into neurons, from a functional point of view, these cells present an immature electrophysiological profile. 27 The implantation of S-MSCs into an adult mouse brain led to the discovery that these cells are capable of differentiating into astrocytes as well as insulinproducing pancreatic cells. 27 An important application of S-MSCs is skin regeneration after serious skin damage, such as that caused by burns, chronic ulcers and deep wounds, as well as anti-ageing therapy and repigmentation in vitiligo, alopaecia and melanoma cases.…”

“…27 The implantation of S-MSCs into an adult mouse brain led to the discovery that these cells are capable of differentiating into astrocytes as well as insulinproducing pancreatic cells. 27 An important application of S-MSCs is skin regeneration after serious skin damage, such as that caused by burns, chronic ulcers and deep wounds, as well as anti-ageing therapy and repigmentation in vitiligo, alopaecia and melanoma cases. Other potential clinical applications of S-MSCs currently being studied include spinal cord injuries, regeneration of the haematopoietic lineage after radiotherapy, bladder reconstruction and alopecia.…”

“…Other potential clinical applications of S-MSCs currently being studied include spinal cord injuries, regeneration of the haematopoietic lineage after radiotherapy, bladder reconstruction and alopecia. 27 Undifferentiated hair follicle stem cells have also been used in murine models of sciatic and tibial nerve transections and crush injuries, with the animals exhibiting improved functional outcomes after cell administration. 9 m u s c l e…”

Dermoscopy Is the Crucial Step for Proper Outcome Prospection When Treating Androgenetic Alopecia with the Regenera<sup>®</sup> Protocol: A Score Proposal

“…Hair transplant aside, the truth is there is no actual treatment capable of creating hair follicles de novo, since a hair follicle is not a single tissue but a tiny, full anatomical structure. The Regenera ® method is no exception to this rule, and its action is based on the regeneration and recovery of severely non-functional but still-alive hair follicles [1][2][3][4] These are called "miniaturized" follicles and, though their presence is not pathognomonic of Androgenetic Alopecia (AA), these hypotrophic and hypofunctioning follicles are naturally found in the course of its evolution. The amount of miniaturized hair follicles is in direct relationship with the severity of AA, which is perfectly characterized by the Hamilton-Norwood and the Ludwig scales.…”