Properties of PVA Hydrogel Wound‐Care Dressings Containing UK Propolis

Oliveira, Renata Nunes; McGuinness, Garrett B.; Ramos, Maria Eduarda T.; Kajiyama, Carolina E.; Thiré, Rossana Mara da Silva Moreira

doi:10.1002/masy.201500149

Cited by 30 publications

(18 citation statements)

References 42 publications

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“…Therefore, the amount of PDN absorbed by the γ-CDHSAs at the saturated time depended on the γ-CD content of the hydrogels. This could be attributed to the formation of inclusion complexes between the hydrophobic γ-CD groups and PDN molecules [ 15 , 20 ]. Consequently, the formation of inclusion complexes could increase the affinity of the γ-CDHSAs hydrogel network for PDN molecules.…”

Section: Resultsmentioning

confidence: 99%

“…Polyvinyl alcohol (PVA) hydrogels [ 15 , 16 , 17 ], dicarboxylic acids (DCAs) [ 18 ] and cyclodextrins (CDs) [ 19 , 20 ] are commonly used as biomaterials because they have a high biocompatibility and are FDA-approve. CDs were selected because they are able to form inclusion complexes (host-guest type) with several classes of compounds including hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

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Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

et al. 2018

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This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of γ-cyclodextrin (γ-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing γ-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of γ-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and γ-CDHSA was mainly produced with the γ-CDs linked to the hydrogels. Thus, the unique structures and properties of γ-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

et al. 2018

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“…Subsequently these samples were taken out at the regular time intervals. The excess water on the surfaces of the samples was removed by blotting gently with filter papers and the samples were weighed immediately [ 27 ]. The swelling degree ( SD %) was calculated as the following equation:

where M t is the weight at interval time t during water absorption, M 1 is the initial weight of the dry gels.…”

Section: Methodsmentioning

confidence: 99%

Physically Crosslinked Hydrogels Based on Poly (Vinyl Alcohol) and Fish Gelatin for Wound Dressing Application: Fabrication and Characterization

et al. 2020

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We developed the interpenetrating double network composite hydrogel based on poly (vinyl alcohol) (PVA) and fish gelatin (FG) via thermal treatment and repeated freeze-thawing. A function of salicylic acid was incorporated into the hydrogel to improve its antibacterial properties. The color values, water contents, water evaporation rate, and swelling behavior were investigated. The drug-loading performance of the composite hydrogel was demonstrated by loading salicylic acid in various hydrogel systems. Moreover, the cumulative dissolution percentage of salicylic acid and the antibacterial activity of composite hydrogel were carried out. The results revealed that as FG concentration increased from 0% to 3.75% (w/v), gels changed from white to slight yellow and the swelling ratio increased from 54% to 83% (within 8 h). The presence of FG decreased the water content of gels which ranged from 86% to 89% and also decreased water evaporation rate. All gels presented the swelling index within 0.5–1.0, indicating a non-Fickian diffusion mechanism. The drug sustained dissolution behavior of pure PVA and composite hydrogel showed the same trend. Besides, the presence of the obvious bacteriostatic zones means that drug-loaded composite hydrogels have an effective antibacterial property. These results demonstrated that PVA/FG-based interpenetrating hydrogel is an appropriate biomaterial for drug-carrying wound dressing application.

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“…Therefore, the structural properties of hydrogel and its affinity for certain bioactive molecules will depend directly on the selection of constituent polymers and the type of crosslinking agent that will form the polymer cross-linked mesh. When considering the above, polyvinyl alcohol (PVA) polymer was selected because it has been used with good results as the base material for the generation of hydrogels for multiple applications [ 22 ], in addition, it is a non-toxic and low-cost polymer [ 23 ]. The preparation of PVA hydrogels can be performed by chemical methods, which involve the formation of interactions and bonds between the PVA chains and the functional groups of the crosslinking agents [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

In-Silico Design, Synthesis and Evaluation of a Nanostructured Hydrogel as a Dimethoate Removal Agent

et al. 2018

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This study describes the in-silico design, synthesis, and evaluation of a cross-linked PVA hydrogel (CLPH) for the absorption of organophosphorus pesticide dimethoate from aqueous solutions. The crosslinking effectiveness of 14 dicarboxilic acids was evaluated through in-silico studies using semiempirical quantum mechanical calculations. According to the theoretical studies, the nanopore of PVA cross-linked with malic acid (CLPH-MA) showed the best interaction energy with dimethoate. Later, using all-atom molecular dynamics simulations, three hydrogels with different proportions of PVA:MA (10:2, 10:4, and 10:6) were used to evaluate their interactions with dimethoate. These results showed that the suitable crosslinking degree for improving the affinity for the pesticide was with 20% (W%) of the cross-linker. In the experimental absorption study, the synthesized CLPH-MA20 recovered 100% of dimethoate from aqueous solutions. Therefore, the theoretical data were correlated with the experimental studies. Surface morphology of CLPH-MA20 by Scanning Electron Microscopy (SEM) was analyzed. In conclusion, the ability of CLPH-MA20 to remove dimethoate could be used as a technological alternative for the treatment of contaminated water.

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Properties of PVA Hydrogel Wound‐Care Dressings Containing UK Propolis

Cited by 30 publications

References 42 publications

Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

Physically Crosslinked Hydrogels Based on Poly (Vinyl Alcohol) and Fish Gelatin for Wound Dressing Application: Fabrication and Characterization

In-Silico Design, Synthesis and Evaluation of a Nanostructured Hydrogel as a Dimethoate Removal Agent

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