Properties of poly[N‐2‐(methyacryloyloxy)ethyl‐N,N‐dimethyl‐N‐3‐sulfopropylammonium betaine] in dilute solution

Abstract

Poly[N-2-(methacryloyloxy)ethyl-N,N-dimethyl-N-3-sulfopropy~ammonium betaine] (1)which is an interesting polyzwitterion polymer by virtue of its "antipolyelectrolyte solution behaviour" has been prepared by free-radical initiated polymerization in aqueous solution.Isothermal fractionation was conducted at 294 K employing formamide as solvent and acetone as precipitant. -Welve fractions covering a wide range of weight-average molecular weight (21 5 OOO 5 M , 5 2070000) were used to characterise the polymer by light scattering, membrane osmometry and viscosity measurements. The Mark-Houwink equations, established for 1 in two good solvents, 2,2,2-trifluoroethanoI (TFE) and 1,0 M aqueous NaCl solution, show that the polymer has a random coil configuration and that TFE is a thermodynamically better solvent than 1 ,O M aqueous NaCl solution. The random coil configuration of 1 in TFE was confirmed from the dependence of the polymer dimensions on molecular weight. 0 1991, Hiithig & Wepf Verlag, Basel CCC 0025-1 16X/91/$05.00

Antimicrobial activity of statistical polymethacrylic sulfopropylbetaines against gram‐positive and gram‐negative bacteria

“…Besides water and aqueous salt solution, polysulfobetaines are generally soluble only in organic solvents such as 2,2,2‐trifluoroethanol TFE, trifluoroacetic acid (TFA), and in some instances formamide. Given that TFE has previously been shown to be a thermodynamically better solvent than salt solution,30 and that Lowe et al5 have also demonstrated that it is a suitable solvent for the molecular dissolution of low molecular weight DMAEMA‐methyl methacrylate block copolymers, we opted to use this as the organic cosolvent. Given the need for dissolution in TSB, clearly not all the copolymers reported in Table I were anticipated to be viable test materials given the hydrophilic and hydrophobic compositions of the materials.…”

Unusual behaviour of crosslinked and linear forms of a zwitterionic polymer in aqueous alkali

“…bases (1 M Na 2 CO 3 , NaOH, KOH and NH 4 OH) and aq. salts (1 M KSCN, KCl, KBr, NH 4 Cl, KI and (NH 4 ) 2 S 2 O 8 ), processes (a) and (b) occurred at pH A 9 (i. e., NaOH, KOH, NH 4 OH and Na 2 CO 3 ). In contrast, neither (a) nor (b) took place in acidic and neutral media.…”

“…Similarly, the total swellability of a zwitterionic xerogel in aqueous salt is greater than that in water alone 2,[5][6][7] . Several studies have already been made on solutions and hydrogels of a common synthetic zwitterionic polymer, poly[N,N-dimethyl-N-methacryloyloxyethyl-N-(3-sulfopropyl)ammonium-betaine](PSPE) 3,4,6) .…”

Effect of the zwitterion structure on the thermo-responsive behaviour of poly(sulfobetaine methacrylates)

“…7,8 These polymers mostly comprise polyzwitterions, in particular of the class of polysulfobetaines. [16][17][18] Although their thermo-responsiveness has been explored occasionally, actually quite some time ago, [19][20][21][22][23] this feature was considered rather a nuisance to their use (e.g. for producing biocompatible or low-fouling materials).…”

“…The strong dependence of the cloud points of P-1 on the concentration and on the type of added inorganic salts, in particular on the anion type in close correlation to the Hofmeister series, is well established. [20][21][22][23]43,57,[77][78][79][80][81][82] Therefore, the strong effects of the added salts and their relative impacts, observed for structurally closely related polymers P-2-P-8 are not surprising. Still, the widespread perception that the interaction of salts with polysulfobetaines can be treated as a general saltingin effect is not adequate, as evident from the evolution of the cloud points as a function of salt concentration.…”