Properties of novel composite meshes in chest wall reconstruction: A comparative animal study

Zardo, Patrick; Zhang, Ruoyu; Freermann, S; Fischer, Steven Roger

doi:10.4103/1817-1737.134071

Cited by 5 publications

(10 citation statements)

References 21 publications

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“…Selective hydrophilic coating is one of them. It may help with some of these issues; however, in our experience it does not sufficiently address them (6). In large series, wound complications including infection, This article is protected by copyright.…”

Section: Discussionmentioning

confidence: 84%

“…Most patches currently in use for chest wall reconstruction are non-absorbable synthetic meshes: polypropylene, polyester and polytetrafluoroethylene (PTFE). Reported disadvantages of these materials include secondary wound infections in as much as 25% of cases, secondary graft dehiscence, seroma formation, insufficient tensile strength, long-term deterioration of lung elasticity and respiratory failure (6,18,19). Various innovations and product developments are currently underway to prevent these issues.…”

Section: Discussionmentioning

confidence: 99%

“…An ideal graft should have a high tensile strength, elasticity, longevity, ease of use, high biocompatibility and low affinity to bacterial adhesion (7). This in turn will allow for good incorporation into adjacent tissue, reduce adhesion formation and potentially facilitate redoprocedures (6).…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Outcome of Chest Wall and Diaphragm Repair with Biological Materials

Merhej,

Ali,

Nakagiri

et al. 2023

Thorac Cardiovasc Surg

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Introduction: Chest wall and/or diaphragm reconstruction aim to preserve, restore or improve respiratory function, conserve anatomical cavities and upkeep postural and upper extremity support. This can be achieved by utilizing a wide range of different grafts made of synthetic, biological, autologous or bioartificial materials. We aim to review our experience with decellularized bovine pericardium as graft in the past decade. Patients and Methods: Retrospective analysis of patients who underwent surgical chest wall and/or diaphragm repair with decellularized bovine pericardium between 01.01.2012 and 13.01.2022 at our institution. All records were screened for patients characteristics, intra/ postoperative complications, chest tube and analgesic therapy duration, length of hospital stay, presence or absence of redo-procedures as well as morbidity and 30-day-mortality. We then looked for correlations between implanted graft size and postoperative complications and gathered further follow-up information at least two months after surgery. Results: A total of n=71 patients either underwent isolated chest wall (n=51), diaphragm (n=12) or pericardial (n=4) resection and reconstruction or a combination thereof. No mortality was recorded within the first 30 days. Major morbidity occurred in 12 patients, comprising secondary respiratory failure requiring bronchoscopy and invasive ventilation in 8 patients, secondary infections and delayed wound healing requiring patch removal in 4 patients. There was no correlation between the extensiveness of the procedure and extubation timing (Chi-test, p=0.44) or onset of respiratory failure (p=0.27). Conclusion: A previously demonstrated general vailability of biological materials for various reconstructive procedures appears to be supported by our long-term results.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

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Long-Term Outcome of Chest Wall and Diaphragm Repair with Biological Materials

Merhej,

Ali,

Nakagiri

et al. 2023

Thorac Cardiovasc Surg

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“…Composite meshes have shown to decrease visceral adhesions in the chest wall [362] and post-operative adhesions in a rat model [363]. The commercially-available tri-component resorbable mesh, Prevadh (Sofradim Production, Trevoux, France) is composed of polylactic acid, lyophilized porcine collagen, and a hydrophilic collagen film.…”

Section: Composite Polymersmentioning

confidence: 99%

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

et al. 2021

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Post-operative adhesions affect patients undergoing all types of surgeries. They are associated with serious complications, including higher risk of morbidity and mortality. Given increased hospitalization, longer operative times, and longer length of hospital stay, post-surgical adhesions also pose a great financial burden. Although our knowledge of some of the underlying mechanisms driving adhesion formation has significantly improved over the past two decades, literature has yet to fully explain the pathogenesis and etiology of post-surgical adhesions. As a result, finding an ideal preventative strategy and leveraging appropriate tissue engineering strategies has proven to be difficult. Different products have been developed and enjoyed various levels of success along the translational tissue engineering research spectrum, but their clinical translation has been limited. Herein, we comprehensively review the agents and products that have been developed to mitigate post-operative adhesion formation. We also assess emerging strategies that aid in facilitating precision and personalized medicine to improve outcomes for patients and our healthcare system.

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“…Composite meshes have traditionally been found suitable for chest wall reconstruction. 6 Complications of thoracic wall mesh placement include lung adhesions, mesh migration or mesh infection. Biological mesh is also associated with an increased cost.…”

mentioning

confidence: 99%