Properties of lipophilic nucleoside monolayers at the air–water interface

Montanha, Érica A.; Pavinatto, Felippe J.; Caseli, Luciano; Kaczmarek, Oliver; Liebscher, J.; Huster, Daniel; Oliveira, Osvaldo N.

doi:10.1016/j.colsurfb.2010.01.017

Cited by 23 publications

(9 citation statements)

References 43 publications

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“…The Langmuir lipid monolayer technique to mimic half a bilayer may be advantageous because properties such as composition, lateral pressure, surface elasticity and surface density are easily controlled [34,35]. First, the surface-active properties of LOCs at an air-water interface were analyzed.…”

Section: Surface Activity Of Locs At Air-water and Lipid-water Interfmentioning

confidence: 99%

Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells

Ugarte‐Uribe¹,

Grijalvo²,

Busto³

et al. 2013

Biochimica et Biophysica Acta (BBA) - General Subjects

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Section: Surface Activity Of Locs At Air-water and Lipid-water Interfmentioning

confidence: 99%

Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells

Ugarte‐Uribe¹,

Grijalvo²,

Busto³

et al. 2013

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…The Langmuir monolayer is a system recognised as able to mimic half of a membrane [8], and basically consists of stable monomolecular-thick films formed when an amphiphile is spread on the top of the air-water interface [9]. Lipids are frequently employed as primary material used to produce such films and are subsequently employed for detailed investigations of the interactions between membrane proteins [10,11], enzymes [12], ions [13], polysaccharides [14], nucleic acid based-compounds [15] and synthetic polymers [16]. Although the use of proteins that interact with only one side of the membrane, such as GPIs, has already been investigated [10], interest is growing in the study of proteins that interact with both sides of the membrane, such as transmembrane proteins [17].…”

Section: Introductionmentioning

confidence: 99%

Surface chemistry and spectroscopy studies on 1,4-naphthoquinone in cell membrane models using Langmuir monolayers

Hussein

Lopes

Filho

et al. 2013

Journal of Colloid and Interface Science

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Investigating the role of drugs whose pharmaceutical activity is associated with cell membranes is fundamental to comprehending the biochemical processes that occur on membrane surfaces. In this work, we examined the action of 1,4-naphthoquinone in lipid Langmuir monolayers at the air-water interface, which served as a model for half of a membrane, and investigated the molecular interactions involved with tensiometry and vibrational spectroscopy. The surface pressure-area isotherms exhibited a noticeable shift to a lower area in relation to 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dihexadecanoyl-sn-glycero-3-phospho-l-serine (DPPS) lipid monolayers, which indicated a disruption of the monolayer structure and solubilisation of the lipids towards the aqueous subphase. To better correlate to the action of this drug in biological membrane events, cell cultures that represented tumorigenic and non-tumorigenic cells were spread onto the air-water interface, and 1,4-naphthoquinone was then incorporated. While only slight changes were observed in the non-tumorigenic cells upon drug incorporation, significant changes were observed in the tumorigenic cells, on which the organisation of the Langmuir monolayers was disrupted as evidenced by tensiometry and vibrational spectroscopy. This work then shows that this drug interacts preferentially for specific surfaces. In simplified models, it has a higher effect for the negative charged DPPS rather than the zwitterionic DPPC; and for complex cell cultures, 1,4-naphthoquinone presents a more significant effect for that representing tumorigenic cells.

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“…Enormous researches are being carried in the quest to replace the surface of electrodes with the NPs to get a fast detection system with greater accuracy level. This has led to boost the scope of research in nano-biosensers, with higher applications in the sectors food pathogen detection, environmental pollution testing and biomedical analysis [56,57].…”

Section: Therapeutical Applications Of Nanosensorsmentioning

confidence: 99%

Biosensor for detection of bacteria with probiotic potential and food pathogens

2020

Lett Appl NanoBioSci

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The exploration for novel nano-sensors has enhanced significantly representing an incredible alternative for the development, speedy, and inexpensive bio-sensing strategy. Due to their low detection volumes, reduction of detection time, high specificity and user-friendly applicability, nano-bio sensors have raised the interest of the scientific community. Nanomaterials are now being used to develop biosensors thatexhibit superior sensitivity and uniqueness with applicability in research investigations, food contamination detection, detection of potential probiotic bacteria, etc. Detection of food contamination is of major significance and concern in areas like healthcare, agriculture, beverage, and fermentation industries. Distinctive biosensing technologies have already been developed for instant monitoring of microbes, food contaminants depending upon the application of nanomaterial. A wide range of nanomaterials, for example, gold nanostructured materials, carbon Copper and silicon nanotubes, GeO 2 /SiO 2 matrix, nanoparticles, nanowires, TiO 2 nanowire, nano-electrode, and nanostructured material arrays are performing an essential role in the bio-sensing application in food pathogen detection and probiotic bacteria detection.Nanosensors merges the principles of information technology and molecular biology proves essential in facilitating immediate detection of foodborne pathogens, contaminants, hence reducing the health risk and medical costs related to foodborne illness.This chapter aims to encompass the types of emerging nanosensors based on different detection technology, their commercial applications, recent advancement in food contamination detection and their future prospects.

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Properties of lipophilic nucleoside monolayers at the air–water interface

Cited by 23 publications

References 43 publications

Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells

Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells

Surface chemistry and spectroscopy studies on 1,4-naphthoquinone in cell membrane models using Langmuir monolayers

Biosensor for detection of bacteria with probiotic potential and food pathogens

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