Properties of kojic acid and curcumin: Assay on cell B16-F1

Abstract

Ultra violet (UV) exposure and oxidative stress are casually linked to skin disorders. They can increase melanin synthesis, proliferation of melanocytes, and hyperpigmentation. It is possible that antioxidants or inhibitors may have a beneficial effect on skin health to reduce hyperpigmentation. In the last few years, a huge number of natural herbal extracts have been tested to reduce hyperpigmentation. The objective of this study was to determine and to compare of kojic acid and curcumin properties to viability cell B16-F1. In this study, our data showed that the viability of cell B16-F1 was 63.91% for kojic acid and 64.12% for curcumin at concentration 100 µg/ml. Further investigation assay of antioxidant activities, indicated that IC50 for kojic acid is 63.8 µg/ml and curcumin is 16.05 µg/ml. Based on the data, kojic acid and curcumin have potential antioxidant properties to reduce hyperpigmentation with low toxicity effect in cell B16-F1.

Curcumin Improves the Regulation of Ovarian Folliculogenesis in Culture Media with Peritoneal Fluid from Infertile Women with Endometriosis

“…This may cause abnormal folliculogenesis and subsequently results in infertility. The PF of women with endometriosis contains a variety of inflammatory mediators, including Tumor Necrosis Factor (TNF)α 5. Curcumin, which is derived from Curcuma longa (turmeric), has a strong potential anti-inflammatory activity 6 . It has been widely used both traditionally and scientifically to treat various conditions including inflammatory diseases, such as rheumatoid arthritis, chronic anterior uveitis and ulcerative colitis 7 .…”