Properties of Ibuprofen Crystallized Under Various Conditions: A Comparative Study

Abstract

Different crystal forms of the analgesic drug ibuprofen were prepared and characterized in this study. Various conditions were used for the crystallization: crystallization was carried out using the solvent change method, the temperature change method, and the solvent evaporation method. Crystals were grown from different solvents. Different crystal forms with different properties were observed: cubic, needle-shaped, and plate-shaped crystals were obtained. Spherical agglomeration occurs when crystallization is carried out in acetonitrile or methanol. Flowability of these spherical crystals is increased. All crystals were determined as isomorphic by differential scanning calorimetry and x-ray analysis--which queries doubtful results of recent publications. Properties like dissolution behavior and properties influencing the manufacturing of dosage forms--like flowability--differ. Thus the choice of the optimal preparation method influencing the crystal habit is important in manufacturing the drug ibuprofen.

Dielectric Relaxation and Crystallization of Ultraviscous Melt and Glassy States of Aspirin, Ibuprofen, Progesterone, and Quinidine

“…45 Ibuprofen is recemic, 46 and shows growth of different crystal shapes. 47 It is uncertain whether or not quinidine has polymorphs.) The finding that e 0 of the crystalline phase of aspirin and quinidine is much greater than e 0 value of 2.5-3 known for the orientationally ordered crystal phase, and for nondipolar liquids, is significant and indicates that crystallization of aspirin and quinidine might have produced an orientationally disordered crystal phase whose e 0 is $4.7 and 3.2, respectively.…”

Precision measurement of the growth rate and mechanism of ibuprofen {001} and {011} as a function of crystallization environment

“…This material mostly has a plate-like crystal morphology dominated by a large {100} face with smaller {001} and {011} side faces. Despite the fact that changes in crystal habit have been reported many times [2,26,[28][29][30][31][32][33][34], detailed studies of growth kinetics for this material have been surprisingly limited. Rashid, et al [11] studied growth rates of ibuprofen crystals grown from ethanol by adding size proportional growth (SPG) seed crystals to an isothermal non-nucleating batch crystallization vessel and sampling the resultant crystals during the batch.…”

Reduktion der Prozessschritte durch unmittelbare Selbstbeschichtung von Partikeln

“…4 ist erkennbar, dass keine Unterschiede in der Kristallinität zwischen dem unbehandelten Ibuprofen und dem Ibuprofen auftraten, das 6 h in der Schmelze isotherm bei 110°C gehalten wurde. Dieses Ergebnis stimmt mit der Arbeit von Raseneck et al [11] überein. In dieser Arbeit wurde Ibuprofen auf unterschiedlichste Weise behandelt, und es konnten keine polymorphen Formen gefunden werden.…”