Properties of fibres, endplates and acetylcholine receptors in the diaphragm, masseter, laryngeal, abdominal and limb muscles in the goat

Ibebunjo, Chikwendu; Srikant, Coimbatore B.; Donati, François

doi:10.1007/bf03018110

Cited by 29 publications

(18 citation statements)

References 36 publications

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“…This relationship between sensitivity and fibre size would not exist if large fibres had correspondingly large endplates, but this is not the case. 20 It is more difficult to explain the relationship between duration of blockade and fibre size or the endplate to fibre size ratio for succinylcholine because there are uncertainties regarding its mechanism of action. The leading hypotheses include (1) desensitization of the endplate; (2) persistent depolarization of the endplate; and/or (3) inactivation of the sodium channels in the perijunctional area.…”

Section: Discussionmentioning

confidence: 99%

Duration of succinylcholine and vecuronium blockade but not potency correlates with the ratio of endplate size to fibre size in seven muscles in the goat

1996

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Section: Discussionmentioning

confidence: 99%

Duration of succinylcholine and vecuronium blockade but not potency correlates with the ratio of endplate size to fibre size in seven muscles in the goat

1996

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“…An effect not evidenced when the motor nerve is stimulated with a 0.1Hz frequency may be partially revealed with 2Hz frequencies and totally revealed when high-frequency stimulation is applied 19 . In addition, the difference in sensitivity between the diverse muscle groups must be considered and varies according to the drug used and the type of muscle fi ber, i.e., it depends on physiologic and histologic differences between muscles 20,21 . It is accepted that red fi bers or slowtwitch muscles, are more sensitive to nondepolarizing neuromuscular blockers than fast-twitch white fi bers.…”

Section: Discussionmentioning

confidence: 99%

Influence of stimulus frequency on blockade induced by pancuronium and rocuronium: study on rats phrenic nerve-diaphragm preparation

et al. 2007

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PURPOSE: To evaluate the influence of two stimulation frequencies on the installation of neuromuscular blockade produced by pancuronium and rocuronium on the rat diaphragm. METHODS: Diaphragms were submitted to an indirect frequency stimulation of 0.1 and 1Hz (Groups I and II, respectively). Subgroups were formed (n=5) according to the neuromuscular blocker employed (pancuronium-2µg/ml and rocuronium-4µg/ml). The twitch height depression was evaluated at 5, 15 and 30 minutes after adding the neuromuscular blocker. RESULTS: The decrease in twitch height was greater (p<0.01) with a frequency of 1Hz at all time periods studied both in preparations that are blocked with pancuronium and in those that are blocked with rocuronium. CONCLUSION: The frequency of stimulation interferes significantly with the installation of neuromuscular blockade produced by pancuronium and rocuronium, since the reduction in amplitude of the rat diaphragm response was greater for 1Hz frequencies, at all periods studied.

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“…Fibre type can have a small influence on the muscle fatty acid profile, with type 1 fibres having a higher concentration of PUFA (Wood et al, 2003). Goat cheek muscle entirely comprises type 1 fibres, whereas 60% of the fibres are type 1 in the diaphragm muscle (Ibebunjo et al, 1996). Assumedly, these concentrations are representative of other ruminant species because of the similar continual phasic activity associated with rumination.…”

Section: Polar Lipidsmentioning

confidence: 99%

Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and Δ5-, Δ6-desaturase protein expression in steer muscles

Turner

Mitchell

Duynisveld

et al. 2012

Animal

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This study investigated effects of roasted or extruded oilseed supplementation ranging in n-6/n-3 ratios from 0.3 to 5.0 on the fatty acid composition and expression of delta-5 desaturase (D5d) and D6-desaturase (D6d) protein in commercial steer cheek (m. masseter) and diaphragm (pars costalis diaphragmatis) muscles. In general, the n-6/n-3 ratio of the diet had a subsequent effect on the muscle n-6/n-3 ratio (P , 0.05), with muscle 18:2n-6 and 18:3n-3 content relating to proportion of dietary soya bean and linseed (P , 0.01). Compared with canola, pure linseed and soya bean diets reduced 14:1c-9 and 16:1c-9 (P , 0.05) but increased 18:1t-11 and c-9,t-11 conjugated linoleic acid (CLA) content (P , 0.01). Oilseed processing had a minor influence but extruded oilseeds increase 18:1t-11 and c-9,t-11 CLA compared with roasted (P , 0.05). Polar lipid 18:3n-3 and n-3 long-chain polyunsaturated fatty acid (LC, >20 carbons PUFA) derivative content increased in relation to dietary linseed supplementation in the diaphragm (P , 0.01), whereas only 18:3n-3 was increased in the cheek (P , 0.01). Protein expression did not differ between diets; however, in each muscle the D5d protein expression had a stronger association with the desaturase products rather than the precursors. The relationship between D5d protein expression and the muscle LC n-6/n-3 ratio was negative in both muscles (P , 0.05). The relationship between D6d protein expression and the LC n-6/n-3 ratio was positive in the cheek (P , 0.001) and negative in the diaphragm (P , 0.05). In conclusion, diet n-6/n-3 ratio affected muscle 18:2n-6 and 18:3n-3 deposition, whereas the D5d and D6d protein expression had some influence on the polar lipid LC-PUFA profile. Results reaffirm that processed oilseeds can be used to increase the proportion of fatty acids potentially beneficial for human health, by influencing the formation of LC-PUFA and reducing the n-6/n-3 ratio.

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Properties of fibres, endplates and acetylcholine receptors in the diaphragm, masseter, laryngeal, abdominal and limb muscles in the goat

Abstract: (577-725 lumz), or AChR density (8,

Cited by 29 publications

References 36 publications

Duration of succinylcholine and vecuronium blockade but not potency correlates with the ratio of endplate size to fibre size in seven muscles in the goat

Duration of succinylcholine and vecuronium blockade but not potency correlates with the ratio of endplate size to fibre size in seven muscles in the goat

Influence of stimulus frequency on blockade induced by pancuronium and rocuronium: study on rats phrenic nerve-diaphragm preparation

Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and Δ5-, Δ6-desaturase protein expression in steer muscles

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