Properties of DNA in concentrated aqueous solutions of LiCl suggest transition to C-DNA
Alexey K. Mazur,
Mounir Maaloum,
Eugene Gladyshev
Abstract:C-DNA represents a canonical DNA form related to B-DNA. While C-DNA is known to exist in air-dried fibers, its occurrence in aqueous solutions remains subject to debate. In fibers, the transition from B- to C-DNA is promoted by reduced hydration in the presence of certain monovalent cations (most notably Li+), and this process is generally associated with an increase in the helical twist. To understand if the B-to-C transition can occur in liquid media in principle, we analyzed properties of several circular D… Show more
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