Properties of Blood Compatible Crosslinked Blends of Pellethene®/Multiblock polyurethanes containing phospholipid moiety/C-18 alkyl chain

Abstract

To improve the mechanical properties, dimensional stability and blood compatibility, the biomedical material Pellethene ® was blended with multiblock polyurethane (MPU) containing phospopholipid /long alkyl chain (C-18) at the various MPU contents and crosslinked using dicumyl peroxide as a crosslinking agent. The maximum MPU content for stable Pellethene ® /MPU blended films was approximately 30 wt%. The optimum crosslinking agent content and crosslinking time with respect to the mechanical properties were 4 wt% and 3 h, respectively. The mechanical properties (tensile strength and elongation at break) and water absorption of the crosslinked blend film increased with increasing MPU content. The test of platelet adhesion on the surfaces of the crosslinked blend film showed a decrease in the level of platelet adhesion from 70% to 6% with increasing MPU content from 0 to 30 wt%. These results suggest that the crosslinked Pellethene ® /MPU-30 (MPU content: 30 wt%) sample has strong potential as a novel material for blood compatible material applications.

Fabrication of endothelial cell-specific polyurethane surfaces co-immobilized with GRGDS and YIGSR peptides

“…As the results, blood-contacting synthetic biomaterials have been found out to generally induce thrombus formation, which is initiated by absorbed plasma proteins on the surfaces, followed by platelet adhesion and activation along coagulation pathways. 7,8 Based upon these phenomena at the interface, various approaches in terms of blood compatibility have been readily attempted and the progresses for modifying surface properties of PU include (1) chemical modification by the grafting of hydrophilic components, like poly(ethylene glycol) (PEG) or biomembrane structure; 4,[9][10][11] (2) surface modification by incorporating bioactive agents such as fibrolytic enzymes (t-plasminogen activator, urokinase), various prostaglandins (PGE 1 ), and potent anticoagulant (heparin and hirudin), through either physical or chemical coupling 9,12-15 and (3) biological modification using protein or endothelial cells (ECs) seeding. 16,17 Among them, the most promising one can be a biomimetic approach that takes advantage of the highly thromboresistance of EC layer, which presents as the inner surface of the natural vessel wall that constitutionally perform a regulatory role in hemostasis.…”

Native chitosan/cellulose composite fibers from an ionic liquid via electrospinning

“…Although Du et al reported that ester derivatives of cellulose and chitosan, which are the two most abundant natural polysaccharides, could be electrospun together, 11,12 non-derivatized polysaccharide hybrids via electrospinning, including chitin, chitosan, cellulose, and heparin are highly challenging due to both the limited availability of volatile solvents and their poor ability to dissolve biopolymers in most common organic and aqueous solvents. [18][19][20][21][22] Hence, in this report, we demonstrate for the first time that it is possible to electrospin non-derivatized chitosancellulose composite fibers from an ionic liquid (IL), 1-ethyl-3-methylimidazolium acetate ([EmIm][Ac]). Ionic liquids, organic liquid salts capable of dissolving both polar and nonpolar compounds, are useful in overcoming the poor solubility of polysaccharides in conventional organic solvents, resulting in potential applications in the chemical and biotechnology industries.…”

Photoluminescent synthetic wood fibers from an ionic liquid via electrospinning

“…1,2 Specifically, biopolymer-based composites fabricated from two or more biopolymers with different physical or chemical properties offer an increased amount of innovative activities for use with various biological applications in tissue engineering, wound healing, biosensor design, imaging, and drug delivery. [3][4][5][6][7][8][9] Although the incorporation of two or more biopolymers to prepare biopolymer-based composites is required to form them into various shapes through electrospinning, molding with templates, or casting to form films, the fabrication of biopolymer-based composites is still a highly challenging task due to the low solubility of many biopolymers used in most conventional solvents. 10,11 However, ionic liquids (ILs) have excellent potential for the dissolution of biopolymers so that two or more biopolymers can be reconstituted into different shapes of biopolymer-based composites, such as fibers, films or monoliths, when a co-solvent such as water, alcohol or acetone is added to a biopolymers-IL solution.…”