Properties of a Calcium Phosphate Cement Synergistically Reinforced by Chitosan Fiber and Gelatin

Pan, Zhao Hui; Cai, He; Jiang, Ping; Fan, Qing

doi:10.1007/s10965-006-9041-2

Cited by 26 publications

(10 citation statements)

References 19 publications

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“…14) However, in this study, the remaining TTCP phase was observed, which would be presumably due to the presence of gelatin in the form of solid granule. 15) The possible influence of the remaining TTCP phase on the biological properties of the samples was examined in the preliminary in vitro tests using MC3T3-E1cells. All of the samples showed very similar behaviors, that is, the cells grew favorably on the cements with strong adhesion.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of porous calcium phosphate cements using gelatin as porogen

Lee

Kim

Koh

2010

J. Ceram. Soc. Japan

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Porous calcium phosphate cements (CPCs) were fabricated using gelatin granules as the porogen. As the amount of gelatin was increased from 0 to 43 vol%, the porosity notably increased from 3 to 47 vol%, while the compressive strength decreased from 23 to 14 MPa; however, these values are still expected to be reasonably high for applications in bone tissue engineering. In addition, osteoblastic cells grew favorably on the surfaces of the CPCs prepared using gelatin of 11 and 43 vol%, which contained well interconnected pores with a size of several hundreds of microns, indicating excellent biocompatibility of the porous CPC samples produced in this study.

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Section: Resultsmentioning

confidence: 99%

Fabrication of porous calcium phosphate cements using gelatin as porogen

Lee

Kim

Koh

2010

J. Ceram. Soc. Japan

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“…A knitted two-dimensionally oriented polyglactin fiber-mesh was found to be effective in improving load-bearing behavior of a calcium orthophosphate cement for potential structural repair of bone defects [199]. To make the material stronger, fast setting and anti-washout, chitosan might be added [178,344,403,[424][425][426][427][428][429][430][431][432][433][434]. Furthermore, anti-washout properties might appear by adding sodium alginate [435].…”

Section: Reinforced Self-setting Formulations and Concretesmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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“…It is obtained by Ndeacetylation of chitin, which is the second most naturally occuring biopolymer after cellulose. 13 Chitosan is distinct from other polysaccarides due to the presence of nitrogen in its molecular structure that makes to be cationic charge and its capacity to form polyelectrolyte complexes. This cationic side allows it become water soluble after the formation with kind of carboxylate salts (formate, acetate, lactate, malate, citrate, glyoxylate, pyruvat, glycolate and ascorbate).…”

Section: Discussionmentioning

confidence: 99%