Properties Investigation of GO/HA/Pt Composite Thin Film

AlYafei, Huda Fadol S.; Fu, Wen; Zalnezhad, E.; Jaber, Fadi; Musharavati, Farayi; Bae, Sung Chul

doi:10.1155/2019/4847932

Cited by 2 publications

(1 citation statement)

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“…In total hip and knee arthroplasty with a polymer cement interface between the implant and the bone, the cement mantle is expected be stable, intact, and firm so that it ensures a well-adaptive physiological bone-remodeling response [34]. However, sometimes, fibrosis may occur between the cement and the implant; and the extent of this fibrosis between implant surface and the cement mantle may enable de-bonding or fatigue fracture spaces which contribute to metallosis from gradual loosening, instability, and wear particles release [35]. Routinely, implants contain a porous coating for protection against fatigue failure that can occur following the degradation of the cement layer around a total hip arthroplasty.…”

Section: Polymer Cement Interfacementioning

confidence: 99%

The Mechanism of Metallosis After Total Hip Arthroplasty

Ude

Esdaille

Ogueri

et al. 2021

Regen. Eng. Transl. Med.

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Metallosis is defined as the accumulation and deposition of metallic particles secondary to abnormal wear from prosthetic implants that may be visualized as abnormal macroscopic staining of periprosthetic soft tissues. This phenomenon occurs secondary to the release of metal ions and particles from metal-on-metal hip implants in patients with end-stage osteoarthritis. Ions and particles shed from implants can lead to local inflammation of surrounding tissue and less commonly, very rare systemic manifestations may occur in various organ systems. With the incidence of total hip arthroplasty increasing as well as rates of revisions due to prosthesis failure from previous metal-on-metal implants, metallosis has become an important area of research. Bodily fluids are electrochemically active and react with biomedical implants. Particles, especially cobalt and chromium, are released from implants as they abrade against one another into the surrounding tissues. The body’s normal defense mechanism becomes activated, which can elicit a cascade of events, leading to inflammation of the immediate surrounding tissues and eventually implant failure. In this review, various mechanisms of metallosis are explored. Focus was placed on the atomic and molecular makeup of medical implants, the component/surgical associated factors, cellular responses, wear, tribocorrosion, joint loading, and fluid pressure associated with implantation. Current treatment guidelines for failed implants include revision surgery. An alternative treatment could be chelation therapy, which may drive future studies. Lay Summary Arthroplasty is an invasive procedure which disrupts surrounding joint tissues, and can greatly perturb the joint’s immune homeostasis. In some instances, this may pose a difficult challenge to implant integration. Particles released from implants into the surrounding joint tissues activate the body’s defense mechanism, eliciting a cascade of events, which leads to biotribocorrosion and electrochemical attacks on the implant. This process may lead to the release of even more particles. Besides, implant makeup and designs, frictions between bearing surfaces, corrosion of non-moving parts with modular junctions, surgical mistakes, patient factor, comorbidities, and loosened components can alter the expected function of implants. High accumulations of these ions and particulates result in metallosis, with accompanying adverse complications. Current recommended treatment for failed prosthesis is revision surgeries. However, chelation therapy as a prophylactic intervention may be useful in future efforts but more investigation is required.

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Section: Polymer Cement Interfacementioning

confidence: 99%