“…These two main components of NC chaperoning activity are also found in other retroviral NC proteins from gamma and alpharetroviruses, 16,17,47,49,50 in the flaviviridae core proteins 58 and in cellular proteins such as p50, FMRP and PrP. 59 In conclusion, the dynamic interplay of the NC hydrophobic platform and basic domains with the viral nucleic acids via the binding, fraying, condensing and annealing properties of NC may well account for its essential functions in virus replication (Fig.…”