Properties and reactions of ylidenemalononitriles

Monocarboxylate Transporter 1 Inhibitors as Potential Anticancer Agents

“…These CHC derivatives of α-cyanocinnamic acids were synthesized from corresponding aldehydes via Knoevenagel type condensation (1−9, Scheme 1B). 20 The compounds 1−9 were evaluated for their MCT1 inhibition activity via [ 14 C]-lactate uptake assay on rat brain endothelial 4 cells (RBE4). We utilized this cell line for initial lactic acid transport studies as they highly express MCT1 as confirmed by Western blotting.…”

DBU Derived Ionic Liquids and Their Application in Organic Synthetic Reactions

“…Knoevenagel condensation is one of the most important methodologies for carbon-carbon double bond formation in synthetic chemistry (Freeman, 1980;Tietze, 1996). The condensation products are the key intermediates for synthesis of natural and therapeutic drugs, polymer, cosmetics and perfumes (Tietze, 2004;Yu et al, 2000).…”

Silica Supported Ammonium Acetate: An Efficient and Recyclable Heterogeneous Catalyst for Knoevenagel Condensation between Adehydes or Ketones and Active Methylene Group in Liquid Phase

“…2 Knoevenagel condensation have numerous applications in the elegant synthesis of fine chemicals, 3 hetero Diels-Alder reactions 4 and in the synthesis of carbocyclic as well as heterocyclic 5 compounds of biological significance. The products of Knoevenagel condensation have found increasing applications in industry, agriculture, medicine and biological science.…”

“…The products of Knoevenagel condensation have found increasing applications in industry, agriculture, medicine and biological science. 3,6 Substituted cinnamic acids possess a wide range of activities such as antiallergic 7 and in the synthesis of substituted styrenes. 8 Numerous reagents have been reported for Knoevenagel condensation in literature such as triethylbenzylammonium chloride (TEBA), 9 NaCl and NH4 OAc-AcOH, 10 26 anionexchange resin, 27 12-tungstophophoric acid.…”