Properties and Applications of PDMS for Biomedical Engineering: A Review

Miranda, Inês; Souza, Andrews; Sousa, Paulo J.; Ribeiro, José Carlos Rabelo; Castanheira, Elisabete M. S.; Lima, Rui; Minas, Graça

doi:10.3390/jfb13010002

Cited by 272 publications

(181 citation statements)

References 169 publications

(278 reference statements)

Supporting

Mentioning

170

Contrasting

Order By: Relevance

“…The aim of this study was to obtain a superhydrophobic coating on aluminum using three consecutive methods: abrasive blasting (mechanical), anodization of aluminum (electrochemical), and impregnation of porous coating by polydimethylsiloxane (chemical). Polydimethylsiloxane is a polymer with a wide range of applications due to its chemical stability, resistance to biodegradation, optical transparency, and favorable mechanical properties [ 27 ]. Many publications describe the use of polydimethylsiloxane (PDMS) to achieve superhydrophobic coatings (including coatings on aluminum), using anodized aluminum oxide as a template to form PDMS nanopillars, and using PDMS in the production of stamps to transfer a lotus leaf structure onto a selected substrate [ 16 , 17 , 18 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Superhydrophobic Coating Based on Porous Aluminum Oxide Modified by Polydimethylsiloxane (PDMS)

et al. 2022

View full text Add to dashboard Cite

The aim of this study was to obtain a superhydrophobic coating by modifying anodized aluminum using polydimethylsiloxane (PDMS). In order to obtain a superhydrophobic coating on an aluminum substrate, a multistage treatment was implemented. Specimens of aluminum were treated by abrasive blasting, anodization in sulfuric acid, impregnation by PDMS, rinsing in toluene to remove excess of PDMS, and curing. A rough surface with an additional low free energy layer on it resulted in a superhydrophobic effect. The coating obtained has an average contact angle of 159°. The specimens were tested in terms of durability in natural conditions. Additionally, anti-icing and anti-fouling properties were evaluated. The coating was compared with anodized aluminum obtained by a basic process.

show abstract

Section: Introductionmentioning

confidence: 99%

Superhydrophobic Coating Based on Porous Aluminum Oxide Modified by Polydimethylsiloxane (PDMS)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…A frequently used material is polydimethylsiloxane (PDMS) [19,20]. PDMS has been widely used in different kinds of research fields [21][22][23][24][25][26][27] due to its excellent properties and ability to replicate reliable geometries, in addition to its high flexibility, low glass transition temperature, good chemical resistance, excellent thermal stability and biocompatibility [28].…”

Section: Introductionmentioning

confidence: 99%

Fluid Flow and Structural Numerical Analysis of a Cerebral Aneurysm Model

Souza

Carvalho

et al. 2022

Fluids

Self Cite

View full text Add to dashboard Cite

Intracranial aneurysms (IA) are dilations of the cerebral arteries and, in most cases, have no symptoms. However, it is a very serious pathology, with a high mortality rate after rupture. Several studies have been focused only on the hemodynamics of the flow within the IA. However, besides the effect of the flow, the development and rupture of the IA are also associated with a combination of other factors such as the wall mechanical behavior. Thus, the objective of this work was to analyze, in addition to the flow behavior, the biomechanical behavior of the aneurysm wall. For this, CFD simulations were performed for different Reynolds numbers (1, 100, 500 and 1000) and for two different rheological models (Newtonian and Carreau). Subsequently, the pressure values of the fluid simulations were exported to the structural simulations in order to qualitatively observe the deformations, strains, normal stresses and shear stress generated in the channel wall. For the structural simulations, a hyperelastic constitutive model (5-parameter Mooney–Rivlin) was used. The results show that with the increase in the Reynolds number (Re), the recirculation phenomenon is more pronounced, which is not seen for Re = 1. The higher the Re, the higher the strain, displacement, normal and shear stresses values.

show abstract

“…During the last 20 years, the progress of microfluidic systems has attracted several researchers and has been applied in several fields ranging from renewable energy to nanomedicine [ 6 , 7 , 8 , 9 ]. In the field of biomedical applications, novel advanced microfluidic devices comprising biomodels have been developed to recreate the microenvironments and cellular functions and interactions present in certain organs.…”

Section: Introductionmentioning

confidence: 99%

Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review

Gonçalves

Carvalho

Rodrigues

et al. 2022

Cancers

Self Cite

View full text Add to dashboard Cite

The development of cancer models that rectify the simplicity of monolayer or static cell cultures physiologic microenvironment and, at the same time, replicate the human system more accurately than animal models has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are a solution that has been explored over the last decade. The combination of microfluidics and cell culture allows the design of a dynamic microenvironment suitable for the evaluation of treatments’ efficacy and effects, closer to the response observed in patients. This systematic review sums the studies from the last decade, where OoC with cancer cell cultures were used for drug screening assays. The studies were selected from three databases and analyzed following the research guidelines for systematic reviews proposed by PRISMA. In the selected studies, several types of cancer cells were evaluated, and the majority of treatments tested were standard chemotherapeutic drugs. Some studies reported higher drug resistance of the cultures on the OoC devices than on 2D cultures, which indicates the better resemblance to in vivo conditions of the former. Several studies also included the replication of the microvasculature or the combination of different cell cultures. The presence of vasculature can influence positively or negatively the drug efficacy since it contributes to a greater diffusion of the drug and also oxygen and nutrients. Co-cultures with liver cells contributed to the evaluation of the systemic toxicity of some drugs metabolites. Nevertheless, few studies used patient cells for the drug screening assays.

show abstract

Properties and Applications of PDMS for Biomedical Engineering: A Review

Cited by 272 publications

References 169 publications

Superhydrophobic Coating Based on Porous Aluminum Oxide Modified by Polydimethylsiloxane (PDMS)

Superhydrophobic Coating Based on Porous Aluminum Oxide Modified by Polydimethylsiloxane (PDMS)

Fluid Flow and Structural Numerical Analysis of a Cerebral Aneurysm Model

Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review

Contact Info

Product

Resources

About