Proper treatment of breast angiosarcoma-mastectomy or breast conserving surgery?

Zdravkovic, Darko; Granić, Miroslav; Crnokrak, Bogdan

doi:10.1007/s10549-019-05509-0

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Expanding the scope of surgical resection or performing axillary lymph node dissection is not recommended. Achieving complete surgical resection with optimal margins serves as the foundation of surgical treatment [ 26 ]. While the optimal surgical approach remains unclear, achieving a negative margin in final surgical resection remains a primary treatment modality.…”

Section: Selection Of Surgical Approachmentioning

confidence: 99%

Angiosarcoma of the breast: A review

An,

Men,

et al. 2024

Heliyon

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Section: Selection Of Surgical Approachmentioning

confidence: 99%

Angiosarcoma of the breast: A review

An,

Men,

et al. 2024

Heliyon

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“…4,5 Nevertheless, modern medical institutions adopt the same treatment management for both primary and secondary angiosarcoma, emphasizing complete surgical excision with optimal margin. 6 The status of chemotherapy and radiotherapy in management strategies remains controversial. 7 The relevant literature that is available is mainly case reports, meta-analyses, and single-center retrospective studies with a limited number of cases.…”

Section: Introductionmentioning

confidence: 99%

“…In general, compared with secondary breast angiosarcoma, primary breast angiosarcoma is considered to occur in younger women with a better prognosis, larger tumor size, and no previous related history 4,5 . Nevertheless, modern medical institutions adopt the same treatment management for both primary and secondary angiosarcoma, emphasizing complete surgical excision with optimal margin 6 . The status of chemotherapy and radiotherapy in management strategies remains controversial 7 …”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

Wang

et al. 2023

Cancer Medicine

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Background: Angiosarcoma of the breast is a rare malignancy. There are little data evaluating the survival and estimating the prognostic factors. The best surgical management and the role of systemic adjuvant therapy remain ill-defined.This study aimed to investigate the clinicopathological features, survival, and prognostic factors of breast angiosarcoma. Methods:The data on patients diagnosed with breast angiosarcoma were extracted from the Surveillance, Epidemiology, and End Results database . Univariate and multivariate Cox regression analyses were used to estimate the influential prognostic factors. The overall survival (OS) and disease-specific survival (DSS) of patients with breast angiosarcoma were evaluated.Results: This study included 656 patients diagnosed with breast angiosarcoma between 1975 and 2016. The 5-year OS rate of all patients was 44.9% (95% CI 40.8-49.0). In both OS and DSS, Kaplan-Meier survival analyses revealed significant differences for both OS and DSS according to age, year at diagnosis, laterality, grade, and stage (all log-rank p < 0.05). Multivariate analysis suggested that lesions of the right breast, poor differentiation, and advanced stage were independent risk factors for OS or DSS (all p < 0.05). Older age was a risk factor in OS, but was protective in DSS. In primary breast angiosarcoma, age, laterality, grade, and stage were independent prognostic factors in OS and DSS (all p < 0.05).Mastectomy was also a risk factor in DSS (p = 0.034). The proportion of patients with grade III and regional disease was larger in the mastectomy group. Conclusion:Angiosarcoma of the breast had a poor prognosis. In our study, age, laterality, histologic grade, and stage were identified as significant prognostic factors. Why patients with angiosarcoma of the right breast had a worse prognosis remains equivocal. Mastectomy was adopted more often by surgeons in this cohort study for patients with advanced primary breast angiosarcoma.

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