Proper names from story recall are associated with beta-amyloid in cognitively unimpaired adults at risk for Alzheimer's disease

Mueller, Kimberly D.; Koscik, Rebecca L.; Du, Lianlian; Bruno, Davide; Jonaitis, Erin M.; Koscik, Audra Z.; Christian, Bradley T.; Betthauser, Tobey J.; Chin, Nathaniel A.; Hermann, Bruce P.; Johnson, Sterling C.

doi:10.1016/j.cortex.2020.07.008

Cited by 19 publications

(16 citation statements)

References 55 publications

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“…As previous studies have acknowledged, PN retrieval measures may be able to identify subtle cognitive changes associated with early pathological processes. 26 In both a voxelwise and penalized regression setting, we have shown that in addition to the effect of entorhinal tau pathology there is a novel effect of fusiform tau and thickness. This demonstrates that PN retrieval is influenced by the spread of tau outside of the entorhinal cortex, which is potentiated by increased Aβ.…”

Section: Discussionmentioning

confidence: 84%

Fusiform Gyrus Phospho‐Tau is Associated with Failure of Proper Name Retrieval in Aging

Tennant

Harrison

Adams

et al. 2021

Annals of Neurology

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Difficulty retrieving proper names is common in older adults, coinciding with the accumulation of aggregated proteins in mid-life. We investigated the ability of healthy older adults to retrieve the names of famous faces in relation to positron emission tomography measurements of amyloid-β plaques and tau neurofibrillary tangles. More tau in the left fusiform and parahippocampal gyrus was related to reduced proper name retrieval performance and this effect was potentiated by amyloid-β. These findings provide an explanation for a common complaint of older adults and link proper name retrieval to neural systems involved in face perception, memory, and naming.

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Section: Discussionmentioning

confidence: 84%

Fusiform Gyrus Phospho‐Tau is Associated with Failure of Proper Name Retrieval in Aging

Tennant

Harrison

Adams

et al. 2021

Annals of Neurology

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“…Relatedly, cognitive tests are relatively unintrusive, thus facilitating data collection on participants who are averse to medical procedures. Second, because subtle neuropsychological changes can be observed already when individuals with elevated levels of AD biomarkers are still asymptomatic for the disease (e.g., Bruno, Mueller, et al, 2021; Mueller et al, 2020).…”

mentioning

confidence: 99%

Cross-sectional associations of CSF tau levels with Rey’s AVLT: A recency ratio study.

Bruno¹,

Zinkunegi²,

Pomara³

et al. 2023

Neuropsychology

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Objective: The preeminent in vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) are amyloid β 1–42 (Aβ42), phosphorylated Tau (p-tau), and total Tau (t-tau). The goal of this study was to examine how well traditional (total and delayed recall) and process-based (recency ratio [Rr]) measures derived from Rey’s Auditory Verbal Learning test (AVLT) were associated with these biomarkers. Method: Data from 235 participants (M age = 65.5, SD = 6.9), who ranged from cognitively unimpaired to mild cognitive impairment, and for whom CSF values were available, were extracted from the Wisconsin Registry for Alzheimer’s Prevention. Bayesian regression analyses were carried out using CSF scores as outcomes, AVLT scores as predictors, and controlling for demographic data and diagnosis. Results: We found moderate evidence that Rr was associated with both CSF p-tau (Bayesian factor [BFM] = 5.55) and t-tau (BFM = 7.28), above and beyond the control variables, while it did not correlate with CSF Aβ42 levels. In contrast, total and delayed recall scores were not linked with any of the AD biomarkers, in separate analyses. When comparing all memory predictors in a single regression, Rr remained the strongest predictor of CSF t-tau levels (BFM = 3.57). Conclusions: Our findings suggest that Rr may be a better cognitive measure than commonly used AVLT scores to assess CSF levels of p-tau and t-tau in nondemented individuals.

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“…Logical memory is a commonly used measure of verbal memory. Previous studies have found that logical memory measures are sensitive to early memory impairment in patients with AD, and it is helpful for distinguishing MCI from Alzheimer's disease (Mueller et al, 2020 ; Orimaye et al, 2020 ). We extracted the average gradient value of overlapping regions of interest (ROIs) and clusters (extracted based on a voxel‐based threshold with AlphaSim correction, defining the minimum cluster extent as 392.7 voxels) and performed a correlation analysis between this value and the CDR‐SOB and logical memory scores with Pearson's correlations.…”

Section: Methodsmentioning

confidence: 99%

Brain network hierarchy reorganization in Alzheimer's disease: A resting‐state functional magnetic resonance imaging study

et al. 2022

Human Brain Mapping

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Hierarchy is a fundamental organizational principle of the human brain network. Whether and how the network hierarchy changes in Alzheimer's disease (AD) remains unclear. To explore brain network hierarchy alterations in AD and their clinical relevance. Forty‐nine healthy controls (HCs), 49 patients with mild cognitive impairment (MCI), and 49 patients with AD were included. The brain network hierarchy of each group was depicted by connectome gradient analyses. We assessed the network hierarchy changes by comparing the gradient values in each network across the AD, MCI, and HC groups. Whole‐brain voxel‐level gradient values were compared across the AD, MCI, and HC groups to identify abnormal brain regions. Finally, we examined the relationships between altered gradient values and clinical features. In the secondary gradient, the posterior default mode network (DMN) gradient values decreased significantly in patients with AD compared with HCs. Regionally, compared with HCs, both MCI and AD groups showed that most of the brain regions with increased gradient values were located in anterior DMN, while most of the brain regions with decreased gradient values were located in posterior DMN. The decrease of gradients in the left middle occipital gyrus was associated with better logical memory performance. The increase of gradients in the right middle frontal gyrus was associated with lower rates of dementia. The network hierarchy changed characteristically in patients with AD and was closely related to memory function and disease severity. These results provide a novel view for further understanding the underlying neuro‐mechanisms of AD.

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Proper names from story recall are associated with beta-amyloid in cognitively unimpaired adults at risk for Alzheimer's disease

Cited by 19 publications

References 55 publications

Fusiform Gyrus Phospho‐Tau is Associated with Failure of Proper Name Retrieval in Aging

Fusiform Gyrus Phospho‐Tau is Associated with Failure of Proper Name Retrieval in Aging

Cross-sectional associations of CSF tau levels with Rey’s AVLT: A recency ratio study.

Brain network hierarchy reorganization in Alzheimer's disease: A resting‐state functional magnetic resonance imaging study

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