2004
DOI: 10.1002/chin.200439110
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Propargylic Sulfones Possessing a 2‐Nitroimidazole Function: Novel Hypoxic‐Cell Radiosensitizers with Intracellular Non‐Protein Thiol Depletion Ability.

Abstract: Ability. -The synthesis of three propargylic sulfones (IX) and (X) containing a 2-nitroimidazole structure is described. Among them, derivative (X) shows the most potent hypoxic radiosensitizing activity. -(TANABE, K.; KOJIMA, R.; HATTA, H.; NISHIMOTO*, S.-I.; Bioorg. Med.

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