Propanediol Phosphate as a Possible Intermediate in the Metabolism of Acetone

Rudney, Harry

doi:10.1016/s0021-9258(18)65461-4

Cited by 65 publications

(3 citation statements)

References 18 publications

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“…Methylglyoxal is further metabolized to pyruvate by two different metabolic routes. Alternatively, acetol can be phosphorylated via the propanediol pathway by a specific kinase, and acetol phosphate is subsequently converted into L-1,2-propanediol, which is either metabolized to L-lactate or split into formate and acetate [27,53,59,60] (figure 1). It is assumed that the L-1,2-propanediol-1-P dehydrogenase catalyzed step probably cannot be managed in the liver [53,60].…”

Section: C3 and C2 Pathwaysmentioning

confidence: 99%

Breath acetone as a potential marker in clinical practice

Ruzsányi

Kalapos²

2017

J. Breath Res.

133

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In recent decades, two facts have changed the opinion of researchers about the function of acetone in humans. Firstly, it has turned out that acetone cannot be regarded as simply a waste product of metabolism, because there are several pathways in which acetone is produced or broken down. Secondly, methods have emerged making possible its detection in exhaled breath, thereby offering an attractive alternative to investigation of blood and urine samples. From a clinical point of view the measurement of breath acetone levels is important, but there are limitations to its wide application. These limitations can be divided into two classes, technical and biological limits. The technical limits include the storage of samples, detection threshold, standardization of clinical settings, and the price of instruments. When considering the biological ranges of acetone, personal factors such as race, age, gender, weight, food consumption, medication, illicit drugs, and even profession/class have to be taken into account to use concentration information for disorders. In some diseases such as diabetes mellitus and lung cancer, as well as in nutrition-related behavior such as starvation and ketogenic diet, breath acetone has been extensively examined. At the same time, there is a lack of investigations in other cases in which ketosis is also evident, such as in alcoholism or an inborn error of metabolism. In summary, the detection of acetone in exhaled breath is a useful and promising tool for diagnosis and it can be used as a marker to follow the effectiveness of treatments in some disorders. However, further endeavors are needed for clarification of the exact distribution of acetone in different body compartments and evaluation of its complex role in humans, especially in those cases in which a ketotic state also occurs. RECEIVED

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Section: C3 and C2 Pathwaysmentioning

confidence: 99%

Breath acetone as a potential marker in clinical practice

Ruzsányi

Kalapos²

2017

J. Breath Res.

133

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“…However, acetone is not a metabolic end product. Acetone is further metabolized in cows (Luick et al, 1967;Black et al, 1972) and rats (Rudney, 1954).…”

Section: Many Metabolite Infusion Experiments Have Been Donementioning

confidence: 99%

Effects of Intraruminal Isopropyl Alcohol Infusions on the Ruminating Behavior of Goats

Asato¹,

Hirata²,

Hirayama³

et al. 2002

Asian Australas. J. Anim. Sci

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Isopropyl alcohol (IPA), produced from acetone by rumen bacterial action, was infused into the rumen of three female goats kept in a climatically controlled experimental room during feeding to investigate the mechanism and roles of IPA in ruminating behavior (number of boli and ruminating time). The ruminating behavior measured by the number of boli, ruminating time, number of remastications, and remasticating time increased (p<0.05) with intraruminal IPA infusion. The concentrations of IPA and acetone in the rumen and the plasma significantly increased (p<0.05) during intraruminal IPA infusion. These data suggest that rumination receptors sensitive to IPA and acetone may be in an area such as the rumen epithelium and the brain stem where they can respond to metabolite levels.

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“…That example stimulated us to conceive the possibility that a hitherto unknown compound, 4-methylthiobutane-l,2-diol (1), could also be ch3sch.,ch,chch,oh OH 1 metabolized to methionine. This concept is supported by several literature references to the assimilation, toxicology, and metabolism of various vicinal glycols (Bayley et al, 1967; Bowen and Waldroup, 1969;Hanzlik et al, 1939a,b;Huff, 1961; Laug et al, 1939;Persons et al, 1968;Rudney, 1954;Scholz, 1950; Waldroup and Bowen, 1968;Yoshida et al, 1969;Yoshida and Ikumo, 1971). Among these references, particularly noteworthy is the comment by Laug et al (1939) that 1,2-propanediol may be converted into a normal body constituent.…”

mentioning

confidence: 90%