Propagation of coherent polarized light in turbid highly scattering medium

Abstract

Within the framework of further development of unified Monte Carlo code for the needs of biomedical optics and biophotonics, we present an approach for modeling of coherent polarized light propagation in highly scattering turbid media, such as biological tissues. The temporal coherence of light, linear and circular polarization, interference, and the helicity flip of circularly polarized light due to reflection at the medium boundary and/or backscattering events are taken into account. To achieve higher accuracy in the results and to speed up the modeling, the implementation of the code utilizes parallel computing on NVIDIA graphics processing units using Compute Unified Device Architecture. The results of the simulation of coherent linearly and circularly polarized light are presented in comparison with the results of known theoretical studies and the results of alternative modelings.

Polarization-sensitive interferometric synthetic aperture microscopy

“…3. The PS-ISAM images for both the birefringent phantom and human tissue samples showed improvement over the PS-OCT images in the anisotropy 7,15 and Sobel 16 image metrics of greater than 50% and 7.5%, respectively. This improved image quality could potentially benefit the detection of residual cancer in breast tumor margins, where the polarization information can aid in the differentiation between normal and diseased tissue by identifying birefringent regions as collagenous stroma.…”

“…The valid polarization information is localized to areas with sufficient signal corresponding to the scattering particles in the intensity images, which have phase retardation values near the extremes of the scale corresponding to right-and left-handed polarization states. 15 Comparison of the PS-OCT and PS-ISAM images reveals improved localization of the phase retardation information in the PS-ISAM reconstruction due to the improved transverse resolution. The traces for a single particle shown in Figs. 2(e) and 2(f) highlight the improvement of the ISAM and PS-ISAM reconstruction over the standard techniques.…”

Propagation and scattering of vector light beam in turbid scattering medium

“…We adapted the Jones-based formalism to handle linear or circular polarization of coherent light traveling through a random turbid medium. 33 The developed MC approach is a part of the O3MC online tool 20,21 and has been extended for modelling propagation and scattering of vector light beams in complex tissue-like scattering media.…”

Reciprocity relation for the vector radiative transport equation and its application to diffuse optical tomography with polarized light

“…Definitely, this requires a larger statistical sample and, in addition, defining some sort of discrete ordinates, which can be numerically problematic. However, if the separation between the source and the detector r ab is sufficiently large, the integration in (13) takes place in the spatial regions where the angular dependence of at least one of the Green's functions involved is relatively weak. We therefore can adopt the following approach to computing the angular dependence of the Green's function.…”

“…Backscattering imaging geometry and illustration of various geometrical objects that are relevant to the reciprocity principle that is considered in this Letter.vRTE is presently not available. Instead, the contemporary mainstream approach to solving vRTE is to use Monte Carlo (MC) simulations [12,13]. However, application of MC simulation to computing the sensitivity function can be so time-consuming as to render the approach impractical.…”