Propagation by COVID-19 at high altitude: Cusco case

Huamaní, Charles; Velásquez, Lucio; Montes, Sonia; Miranda-Solis, Franklin

doi:10.1016/j.resp.2020.103448

Cited by 28 publications

(32 citation statements)

References 3 publications

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“…By June 13, 2020, the cumulative case-fatality rate for Peru was 2.33 %. In Cusco city (3414 m) case-fatality rate was 0.52 % similar to that observed by Huamaní et al (2020)…”

Section: Resultssupporting

confidence: 84%

“…By April 28, 2020 for Cusco, Peru (3414 m) was observed 0.5 % of case-fatality rate for the native population. This value is lower that the Peruvian case-fatality rate of 2.8 % (Huamaní et al, 2020). Although, the figures may support the hypothesis that life in HA may provide some protection from severe COVID-19, it is necessary to be cautious before reach to a conclusion (Burtscher et al, 2020).…”

Section: Introductionmentioning

confidence: 71%

“…A recent paper with data as of April 7th from the Tibet, Bolivia and Ecuador suggests that high-altitude (HA) may provide protection from pathogenesis of SAR-CoV-2 infection (Arias-Reyes et al, 2020). A more recent paper with data from Cusco, Peru, concluded that the disease symptoms are not different in residents at high altitude (Huamaní et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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High altitude reduces infection rate of COVID-19 but not case-fatality rate

Segovia-Juárez

Castagnetto

Gonzáles

2020

Respiratory Physiology & Neurobiology

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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“…By June 13, 2020, the cumulative case-fatality rate for Peru was 2.33 %. In Cusco city (3414 m) case-fatality rate was 0.52 % similar to that observed by Huamaní et al (2020)…”

Section: Resultssupporting

confidence: 84%

Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High altitude reduces infection rate of COVID-19 but not case-fatality rate

Segovia-Juárez

Castagnetto

Gonzáles

2020

Respiratory Physiology & Neurobiology

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“…Subsequent reports from other research groups supported this observation (Huamaní, Velásquez, Montes, & Miranda-Solis, 2020;Ortiz-Prado et al, 2020;Rivero & Montoya, 2020).…”

Section: Introductionmentioning

confidence: 80%

Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent

Arias‐Reyes

Carvajal-Rodriguez

Poma-Machicao

et al. 2020

Preprint

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The coronavirus disease 2019 (COVID-19) outbreak in North, Central, and South America has become the epicenter of the current pandemic. We have suggested previously that the infection rate of this virus might be lower in people living at high altitude (over 2,500 m) compared to that in the lowlands. Based on data from official sources, we performed a new epidemiological analysis of the development of the pandemic in 23 countries on the American continent as of May 23, 2020. Our results confirm our previous finding, further showing that the incidence of COVID-19 on the American continent decreases significantly starting at 1,000 m above sea level (masl). Moreover, epidemiological modeling indicates that the virus transmission rate capacity is lower in the highlands (>1,000 masl) than in the lowlands (<1,000 masl). Finally, evaluating the differences in the recovery percentage of patients, the death-to-case ratio, and the theoretical fraction of undiagnosed cases, we found that the severity of COVID-19 is also decreased above 1,000 m. We conclude that the impact of the COVID-19 decreases significantly with altitude.

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“…O ver 140 million people live at high altitude (>2500 m) across several continents (Cohen and Small, 1998;Penaloza and Arias-Stella, 2007), and many of these mountainous regions are increasingly accessible with modern means of transportation (West, 2008;Reisman et al, 2017). Cases of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported from high-altitude regions of Europe, Asia, South America, North America, and Africa (Arias-Reyes et al, 2020;Huamaní et al, 2020;Xi et al, 2020;Zeng et al, 2020). Interestingly and provocatively, an epidemiological analysis by Arias-Reyes et al (2020) pointed out a lower reported incidence of COVID-19 and proposed a possible weaker transmission rate of severe SARS-CoV-2 among high-altitude populations.…”

Section: Introductionmentioning

confidence: 99%

Lower Incidence of COVID-19 at High Altitude: Facts and Confounders

Pun

Turner

Strapazzon

et al. 2020

High Altitude Medicine & Biology

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The rapid transmission, increased morbidity, and mortality of coronavirus disease 2019 (COVID-19) has exhausted many health care systems and the global economy. Large variations in COVID-19 prevalence and incidence have been reported across and within many countries worldwide; however, this remains poorly understood. The variability and susceptibility across the world have been mainly attributed to differing socioeconomic status, burden of chronic diseases, access to health care, strength of health care systems, and early or late adoption of control measures. Environmental factors such as pollution, ambient temperature, humidity, and seasonal weather patterns at different latitudes may influence how severe the pandemic is and the incidence of infection in any part of the world. In addition, recent epidemiological data have been used to propose that altitude of residence may not only influence those environmental features considered key to lesser viral transmission, but also susceptibility to more severe forms of COVID-19 through hypoxic-hypobaria driven genomic or nongenomic adaptations specific to high-altitude populations. In this review, we critically examine these factors and attempt to determine based upon available scientific and epidemiological data whether living in high-altitude regions might be protective against COVID-19 as recent publications have claimed.

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Propagation by COVID-19 at high altitude: Cusco case

Cited by 28 publications

References 3 publications

High altitude reduces infection rate of COVID-19 but not case-fatality rate

High altitude reduces infection rate of COVID-19 but not case-fatality rate

Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent

Lower Incidence of COVID-19 at High Altitude: Facts and Confounders

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