Propacetamol and diclofenac alone and in combination for analgesia after elective tonsillectomy

Hiller, Arja; Silvanto, M.; Savolainen, Sauli; Tarkkila, P.

doi:10.1111/j.1399-6576.2004.00473.x

Cited by 47 publications

(39 citation statements)

References 13 publications

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“…Rømsing and his group in their systematic review reported that concurrent use of paracetamol and an NSAID was superior to paracetamol but not to NSAID [21]. In contrast, Hiller and his colleagues [22] reported that combined therapy with propacetamol and diclofenac offered no clinical advantage over monotherapy as regards postoperative analgesia in adult elective tonsillectomy patients. The difference between studies could be attributed to the study design, type of the procedure and selected population.…”

Section: Discussionmentioning

confidence: 95%

Pre‐operative analgesia with rectal diclofenac and/or paracetamol in children undergoing inguinal hernia repair

Riad

Moussa

2007

Anaesthesia

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SummaryBoth rectal diclofenac and paracetamol are commonly used to treat acute postoperative pain in children but combining them to improve the quality of analgesia is controversial. This study aimed to detect whether the pre-operative combined administration of rectal diclofenac and paracetamol is superior to either drug alone. One hundred and eight patients were randomly assigned to receive either rectal diclofenac 1 mg.kg )1 or paracetamol 40 mg.kg )1 or their combination 1 h prior to surgery. In the first 24 h postoperatively, pain was assessed using the Wong and Baker Pain Scale. If the patients experienced a pain score of 2 or more, morphine was given. The total dose of morphine and number of doses required were recorded. Children who received the rectal diclofenac-paracetamol combination experienced a lower pain scale and a decreased need for morphine compared with children receiving each drug alone.

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Section: Discussionmentioning

confidence: 95%

Pre‐operative analgesia with rectal diclofenac and/or paracetamol in children undergoing inguinal hernia repair

Riad

Moussa

2007

Anaesthesia

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“…1,11 Combination of two nonsteroidal anti-inflammatory drugs (diclofenac, naproxen, etodolac) with paracetamol was commonly used in our study, but when both are added the increase in efficacy is not much. 12 FDCs of diclofenac+serratopeptidase do not offer any particular advantage over the individual drugs despite the claim that serratopeptidase promotes more rapid resolution of inflammation. 13 Dicyclomine and paracetamol combination is highly irrational as paracetamol promotes sweating and thereby helps in heat dissipation.…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study to assess the rationality of fixed dose combinations prescribed in geriatric patients in a tertiary care hospital

Dakappa

Narayanareddy

2016

Int J Basic Clin Pharmacol

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“…19 In this study we used analgesic at optimum dose and regular basis in both control group and study group.…”

Section: Resultsmentioning

confidence: 99%

Assesment of The Effect of Multimodal Preemptive Analgesia in Children

Nooruzzaman

Pervez

Akan³

et al. 2014

J. paediatr. surg. Bangladesh

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Preemptive analgesia, an evolving clinical concept, involves the introduction of an analgesic regimen before the onset of noxious stimuli, with the goal of preventing sensitization of the nervous system to subsequent stimuli that could amplify pain. Pain is inevitable after any surgery. Surgery offers the most promising setting for preemptive analgesia because the timing of noxious stimuli is known. Therefore this study concludes that administrations of multimodal pre-emptive analgesia control pain more effectively in children in view of both the degree of pain control and sustainability of pain free state.

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Propacetamol and diclofenac alone and in combination for analgesia after elective tonsillectomy

Abstract: Combined treatment with propacetamol and diclofenac with the dosages used provided clinically only a minor advantage over monotherapy with propacetamol or diclofenac with respect to postoperative analgesia or the incidence of side-effects in adult tonsillectomy patients.

Cited by 47 publications

References 13 publications

Pre‐operative analgesia with rectal diclofenac and/or paracetamol in children undergoing inguinal hernia repair

Pre‐operative analgesia with rectal diclofenac and/or paracetamol in children undergoing inguinal hernia repair

A cross-sectional study to assess the rationality of fixed dose combinations prescribed in geriatric patients in a tertiary care hospital

Assesment of The Effect of Multimodal Preemptive Analgesia in Children

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