Prooxidant–anti-oxidant balance is not associated with extent of coronary artery disease

Rahsepar, Amir Ali; Pourghadamyari, Hossein; Moohebati, Mohsen; Parizadeh, Seyed Mostafa; Tavallaie, Shima; Paydar, Roghayeh; Falsoleiman, Homa; Dehghani, Mahboobe; Fazlinezhad, Afsoon; Amini, Maral; Khorashadizadeh, Fatemeh; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.

doi:10.1016/j.clinbiochem.2011.08.1133

Cited by 17 publications

(14 citation statements)

References 28 publications

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“…The following conventional cardiovascular risk factors were defined: dyslipidemia [total cholesterol ≥200 mg/dl and/or LDL cholesterol (LDL-C) ≥130 mg/dl and/or use of cholesterol-lowering drugs], diabetes (fasting blood glucose ≥126 mg/dl and/or use of pharmacological treatment), arterial hypertension (systolic blood pressure >140 mm Hg and/or diastolic blood pressure >90 mm Hg and/or use of antihypertensive drugs) [26]. …”

Section: Methodsmentioning

confidence: 99%

Prooxidant-Antioxidant Balance and Antioxidized LDL Antibody Level Values and Cardiac Function in Patients with Coronary Artery Disease

Rahsepar

Mirzaee²,

Moodi³

et al. 2012

Cardiology

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Objectives: We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD). Methods: Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients. Results: PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r = –0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05). Conclusion: Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB.

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Section: Methodsmentioning

confidence: 99%

Prooxidant-Antioxidant Balance and Antioxidized LDL Antibody Level Values and Cardiac Function in Patients with Coronary Artery Disease

Rahsepar

Mirzaee²,

Moodi³

et al. 2012

Cardiology

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“…In contrast, Rahsepar et al [3 ]reported that the PAB value was not associated with the extent of CAD, stratified by the number of stenotic vessels in coronary arteries. …”

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confidence: 99%

Prooxidant-Antioxidant Balance and Risk Factors of Coronary Artery Disease

Kawada

2013

Cardiology

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“…However, when the finely balanced equilibrium between free radical production and cellular antioxidant defenses is shifted in favor of more free radical production collectively called oxidative stress; this can promote cellular injury (4,5). Clinical and experimental studies have shown that disturbing of oxidant-antioxidant balance system is involved in the pathogenesis of chronic diseases such as cancer (6), coronary heart disease (7,8), diabetes and many diabetic complications (9).…”

Section: Introductionmentioning

confidence: 99%

Effect of Sodium Selenite on Lipid Peroxidation and Glutathione in Alloxan Induced Diabetic Rats

Ahmadvand

Khosrowbeygi

2015

Zahedan J Res Med Sci

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Background: Diabetes-related dysfunctions are the major causes of mortality and morbidity for diabetic patients. Objectives: Selenium is a potent antioxidant. In the present study, we examined antioxidative activities of sodium selenite and possible protective effect of it on serum, liver and kidney lipid peroxidation and glutathione in alloxan-induced type 1 diabetic rats. Materials and Methods: In this experimental study 40 Sprage Dawley male rats were divided into 4 groups randomly; group I as control, group II as sham treated with sodium selenite (1 mg/kg i.p. daily), group III as diabetic untreated, and group IV as diabetic treated with sodium selenite (1 mg/kg i.p. daily) after induce diabetes, respectively. Diabetes was induced in the 3rd and 4th groups by alloxan injection (s.c.). After 8 weeks, animals were anaesthetized, liver and kidney were then removed immediately and used fresh or kept frozen until analysis. Blood samples were also collected before killing of the rats to measure the lipid peroxidation and glutathione level. Results: Liver and kidney content of lipid peroxidation decreased in diabetic treated group compared with untreated group. Kidney content of glutathione significantly increased in diabetic treated group compared with untreated group. Serum level of glutathione and liver content of it slightly increased in diabetic treated group compared with untreated group. Conclusions: This study showed that sodium selenite might be a potent antioxidant and exert beneficial effects on the lipid peroxidation and glutathione in alloxan-induced type 1 diabetic rats.

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Prooxidant–anti-oxidant balance is not associated with extent of coronary artery disease

Cited by 17 publications

References 28 publications

Prooxidant-Antioxidant Balance and Antioxidized LDL Antibody Level Values and Cardiac Function in Patients with Coronary Artery Disease

Prooxidant-Antioxidant Balance and Antioxidized LDL Antibody Level Values and Cardiac Function in Patients with Coronary Artery Disease

Prooxidant-Antioxidant Balance and Risk Factors of Coronary Artery Disease

Effect of Sodium Selenite on Lipid Peroxidation and Glutathione in Alloxan Induced Diabetic Rats

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