Proof of Concept: Protein Delivery into Human Erythrocytes Using Stable Cavitation

Chettab, Kamel; Matera, Eva–Laure; Lafond, Maxime; Coralie, Durieux; Favin-Lévêque, Camille; Goy, Clémence; Strakhova, Regina; Mestas, Jean‐Louis; Lafon, Cyril; Dumontet, Charles

doi:10.1021/acs.molpharmaceut.1c00907

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…The use of PCI coupled with an assessment of neointimal hyperplasia after pioglitazone delivery would allow the choice of acoustic parameters to be optimized to obtain this beneficial bioeffect. Recent publications suggest that both inertial cavitation and stable cavitation promote drug delivery [47][48][49][50] . Inertial cavitation opens endothelial tight junctions [12][13][14] , and acoustic streaming caused by stable or inertial cavitation [51][52][53][54] increases drug transport across the endothelium 16,17 .…”

Section: Discussionmentioning

confidence: 99%

Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter

Kennedy

Lafond

Haworth

et al. 2023

Sci Rep

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Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammatory agent were characterized before and after infusion through an EkoSonic catheter. Cavitation activity was nucleated by Definity or fibrin-targeted, drug-loaded echogenic liposomes infused and insonified with EkoSonic catheters. Passive cavitation imaging was used to quantify and map bubble activity in a flow phantom mimicking porcine arterial flow. Cavitation was sustained during 3-min infusions of Definity or echogenic liposomes along the distal 6 cm treatment zone of the catheter. Though the EkoSonic catheter was not designed specifically for cavitation nucleation, infusion of drug-loaded echogenic liposomes can be employed to trigger and sustain bubble activity for enhanced intravascular drug delivery.

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Section: Discussionmentioning

confidence: 99%

Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter

Kennedy

Lafond

Haworth

et al. 2023

Sci Rep

Self Cite

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“…To prepare RBC carriers, some methods like hypotonic swelling and hypotonic dialysis [35][36][37][38][39], sonoporation [40], fluidic shear stress [41], electroporation [42], using chlorpromazine (CPZ), and fusion with liposomes [43] have been adopted. The most used method is hypotonic swelling.…”

Section: Rbcs Intracellular Drug Loadingmentioning

confidence: 99%

Red blood cells: a potential delivery system

Chen,

Leng,

et al. 2023

J Nanobiotechnol

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Red blood cells (RBCs) are the most abundant cells in the body, possessing unique biological and physical properties. RBCs have demonstrated outstanding potential as delivery vehicles due to their low immunogenicity, long-circulating cycle, and immune characteristics, exhibiting delivery abilities. There have been several developments in understanding the delivery system of RBCs and their derivatives, and they have been applied in various aspects of biomedicine. This article compared the various physiological and physical characteristics of RBCs, analyzed their potential advantages in delivery systems, and summarized their existing practices in biomedicine. Graphical Abstract

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Engineering of Erythrocytes as Drug Carriers for Therapeutic Applications

Jia,

Shi,

Yan

et al. 2024

Advanced Biology

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Erythrocytes, also known as red blood cells (RBCs), have garnered considerable attention as potential carriers for drug delivery, owing to their inherent properties such as biocompatibility, biodegradability, and prolonged circulation half‐life. This paper presents a comprehensive overview of the role of erythrocytes in drug delivery, elucidating recent advancements in delivering a diverse array of therapeutic agents, including small molecules, nucleic acids, antibodies, protein enzymes, and nanoparticles. Two primary strategies for encapsulating drugs within erythrocytes are systematically discussed: internal loading and surface loading. Each strategy offers distinct advantages in terms of drug stability and release kinetics. Notably, the utilization of erythrocyte membrane camouflaged nanocarriers holds promise for enhancing the biocompatibility of conventional nanoparticles and facilitating targeted drug delivery. Furthermore, the broad spectrum of biomedical applications of erythrocyte‐based drug delivery systems are examined, ranging from cancer treatment to diabetes management, thrombosis prevention, and immunotherapy. This review provides a comprehensive evaluation of current technologies in erythrocyte‐loaded drug delivery, highlighting the strengths, weaknesses, and future directions for advancing therapeutic interventions in various disease contexts.

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Proof of Concept: Protein Delivery into Human Erythrocytes Using Stable Cavitation

Cited by 5 publications

References 45 publications

Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter

Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter

Red blood cells: a potential delivery system

Engineering of Erythrocytes as Drug Carriers for Therapeutic Applications

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