Pronuclear embryo cryopreservation experience: outcomes for reducing the risk of ovarian hyperstimulation syndrome and for fertility preservation in cancer patients

Sabatini, Mary E.; Wolkovich, A.M.; Macklin, Eric A.; Wright, Donald R.; Souter, Irene; Toth, Thomas L.

doi:10.1007/s10815-010-9515-3

Cited by 14 publications

(10 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found a 42.1% delivery rate per transfer, which we consider good for day 3 embryo transfer in the setting of these patients having had all, not just good quality, embryos frozen and subsequently thawed and transferred. This rate is also consistent with our prior reports as well as those of others, which range from 12 to 75% [ 5 , 12 , 15 , 27 – 32 ]. However, all studies, including our own, have small sample sizes ranging from 4 to 33 patients.…”

Section: Discussionsupporting

confidence: 94%

Responses to fertility treatment among patients with cancer: a retrospective cohort study

Dolinko

Farland

Missmer

et al. 2018

Fertil Res and Pract

View full text Add to dashboard Cite

BackgroundCancer treatments have significant negative impacts on female fertility, but the impact of cancer itself on fertility remains to be clarified. While some studies have shown that compared with healthy women, those with cancer require higher doses of gonadotropins resulting in decreased oocyte yields, others have shown comparable oocyte yields between the two groups. The purpose of this study is to evaluate whether there is an association between any cancer and/or type of cancer, and response to ovarian stimulation for egg and embryo banking.MethodsIn this retrospective cohort study, ovarian stimulation cycles performed from June 2007 through October 2014 at a single academic medical center were reviewed to identify those undertaken for women with cancer undergoing fertility preservation (n = 147) or women with no cancer undergoing their first cycle due to male factor infertility (n = 664). Of the 147 women undergoing fertility preservation, 105 had local cancer (Stage I-III solid malignancies) and 42 had systemic cancer (hematologic or Stage IV solid malignancies). Response to ovarian stimulation was compared among these two groups and women with no cancer.ResultsAdjusting for age and BMI, women with systemic cancer had lower baseline antral follicle counts (AFC) than women with no cancer or local cancer. Women with systemic cancer required higher doses of FSH than women with no cancer or local cancer, and they had higher oocyte to AFC ratios than women with no cancer or local cancer, but greater odds of cycle cancellation as compared to women with no cancer or local cancer. No significant differences were observed among the three groups for duration of stimulation, number of oocytes and mature oocytes retrieved, or number of embryos created.ConclusionsWomen with cancer achieve similar oocyte and embryo yields as women with no cancer, although those with systemic cancer require higher FSH doses and are at greater risk of cycle cancellation.

show abstract

Section: Discussionsupporting

confidence: 94%

Responses to fertility treatment among patients with cancer: a retrospective cohort study

Dolinko

Farland

Missmer

et al. 2018

Fertil Res and Pract

View full text Add to dashboard Cite

show abstract

“…This is in contrast to prior studies, which have shown that live birth and pregnancy rates for cancer patients who undergo cryopreservation of embryos are lower than that of the general population seeking infertility treatment, however these studies are limited by their inclusion of only a small number of cancer patients [41,42]. Michaan et al reported similar clinical pregnancy rates between cancer patients and controls with tubal factor infertility, however their study is limited by small numbers (21 cancer patients) and by the fact that only 4 patients returned for transfer resulting two live births [26].…”

Section: Discussionmentioning

confidence: 72%

Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience

Cardozo

Thomson

Karmon

et al. 2015

J Assist Reprod Genet

Self Cite

View full text Add to dashboard Cite

Purpose To compare the in-vitro fertilization (IVF) outcomes of cancer patients who underwent oocyte retrieval and embryo/ oocyte cryopreservation prior to gonadotoxic therapy to those of age and time-matched controls with tubal factor infertility. Methods All cancer patients who underwent embryo/oocyte cryopreservation at our institution from 1997 to 2014 were reviewed. Primary outcomes were total dose of gonadotropins used, number of oocytes retrieved, and number of 2pn embryos obtained. Outcomes were compared to age-matched controls with tubal-factor infertility who underwent a fresh embryo transfer within the same relative time period as the IVF cycle of the cancer patient. Results Sixty-three cancer patients underwent 65 IVF cycles, and 21 returned for frozen embryo transfer. One hundred twenty-two age-matched controls underwent IVF cycles with fresh transfer, and 23 returned for frozen embryo transfer. No difference was seen between cancer patients and controls with respect to total ampules of gonadotropin used (38.0 vs. 35.6 respectively; p=0.28), number of oocytes retrieved (12.4 vs. 10.9 respectively; p=0.36) and number of 2pn embryos obtained (6.6 vs. 7.1 respectively; p=0.11). Cumulative pregnancy rate per transfer for cancer patients compared to controls was 37 vs. 43 % respectively (p=0.49) and cumulative live birth rate per transfer was 30 vs. 32 % respectively (p=0.85). Cancer patients had a higher likelihood of live birth resulting in twins (44 vs. 14 %; p=0.035). Conclusions Most IVF outcomes appear comparable for cancer patients and age-matched controls. Higher twin pregnancy rates in cancer patients may reflect lack of underlying infertility or need for cancer-specific transfer guidelines.

show abstract

“…Indeed, Sabatini et al [10] reported in 2011 a lower LBR after transfer of frozen embryos in cancer patients compared to women who underwent fresh embryo transfer in their department (LBR 35 %). However, their study published in 2015 on a series of 57 cancer patients who had embryos cryopreserved, showed a similar LBR per transfer between cancer patients and controls [11].…”

Section: Pregnancy Ratementioning

confidence: 99%

“…Very little has been published on the efficacy and utilization rates of long-term embryo cryopreservation in cancer patients [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment

Dolmans

Ouderaen

Demylle

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The aim of this study was to evaluate long-term embryo cryopreservation, utilization, and success rate in patients subjected to gonadotoxic treatments in the context of cancer. Methods This is a retrospective study on patients (n=54) undergoing ovarian stimulation and IVF for fertility preservation between January 1997 and June 2014. Embryos were slowfrozen and stored until the women were cured and able to undergo embryo transfer. Results Fifty-four women underwent 66 oocyte pick-up procedures in total, and embryos were obtained from 52 of the 54 patients. Four patients died before their frozen embryos could be thawed. Of the remaining 48, 9 women returned to use their embryos, resulting in 6 pregnancies (66 % cumulative pregnancy rate), two of which ended in miscarriage. The live birth rate per patient was thus 44 % (4/9). The true come-back rate, calculated after applicable exclusions, was found to be 23 %. Conclusion IVF followed by embryo freezing is a widely established technique for fertility preservation, but little has been published on the outcomes in cancer patients. While we found the number of good-quality embryos to be lower than in a normal population, the cumulative live birth rate was similar to that achieved with fresh embryos in non-cancer patients. The utilization rate of this fertility preservation method can be considered high.

show abstract

Pronuclear embryo cryopreservation experience: outcomes for reducing the risk of ovarian hyperstimulation syndrome and for fertility preservation in cancer patients

Cited by 14 publications

References 36 publications

Responses to fertility treatment among patients with cancer: a retrospective cohort study

Responses to fertility treatment among patients with cancer: a retrospective cohort study

Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience

Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment

Contact Info

Product

Resources

About