Pronóstico de la infección profunda en la cirugía raquídea con implante, tratada mediante retención, retirada del injerto óseo y antibioterapia prolongada

Caceres, Aileen; Jiménez, J.S. Lucena; Martín-Gallego, Álvaro; Duran, Joan; Diaz, B. Sobrino; Puerta, D. García de Quevedo

doi:10.1016/j.recot.2018.10.001

Cited by 2 publications

(2 citation statements)

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“…Risk factors beyond indication undoubtedly also have an impact on incidence. Many included studies collected demographic risk factor information, like advanced age, high body mass index, steroid use, and renal disease 11,62,71 . Intraoperative factors like length of surgery and use of multiple equipment intraoperatively reportedly increased the risk of infection 63 .…”

Section: Discussionmentioning

confidence: 99%

“…Many included studies collected demographic risk factor information, like advanced age, high body mass index, steroid use, and renal disease. 11,62,71 Intraoperative factors like length of surgery and use of multiple equipment intraoperatively reportedly increased the risk of infection. 63 Relatively few studies conducted formal analyses of risk factors in terms of incidence of infection, although Smith et al 5 identify revision surgery, spinal fusion, and use of implants as statistically significant risk factors for increased infection rate.…”

Section: Discussionmentioning

confidence: 99%

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Incidence and Recurrence of Deep Spine Surgical Site Infections

Freire-Archer

Sarraj

Koziarz

et al. 2023

Spine

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Study Design. Systematic review and meta-analysis. Objective. To determine a pooled incidence rate for deep surgical site infection (SSI) and compare available evidence for deep SSI management among instrumented spinal fusions. Summary of Background Data. Deep SSI is a common complication of instrumented spinal surgery associated with patient morbidity, poorer long-term outcomes, and higher health care costs. Materials and Methods. We systematically searched Medline and Embase and included studies with an adult patient population undergoing posterior instrumented spinal fusion of the thoracic, lumbar, or sacral spine, with a reported outcome of deep SSI. The primary outcome was the incidence of deep SSI. Secondary outcomes included persistent deep SSI after initial debridement, mean number of debridements, and microbiology. The subsequent meta-analysis combined outcomes for surgical site infection using a random-effects model and quantified heterogeneity using the χ2 test and the I 2 statistic. In addition, a qualitative analysis of management strategies was reported. Results. Of 9087 potentially eligible studies, we included 54 studies (37 comparative and 17 noncomparative). The pooled SSI incidence rate was 1.5% (95% CI, 1.1%–1.9%) based on 209,347 index procedures. Up to 25% of patients (95% CI, 16.8%–35.3%), had a persistent infection. These patients require an average of 1.4 (range: 0.8–1.9) additional debridements. Infecting organisms were commonly gram-positive, and among them, staphylococcus aureus was the most frequent (46%). Qualitative analysis suggests implant retention, especially for early deep SSI management. Evidence was limited for other management strategies. Conclusions. The pooled incidence rate of deep SSI post-thoracolumbar spinal surgery is 1.5%. The rate of recurrence and repeat debridement is at least 12%, up to 25%. Persistent infection is a significant risk, highlighting the need for standardized treatment protocols. Our review further demonstrates heterogeneity in management strategies. Large-scale prospective studies are needed to develop better evidence around deep SSI incidence and management in the instrumented thoracolumbar adult spinal fusion population.

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Section: Discussionmentioning

confidence: 99%