Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test

Rocha-González, Héctor Isaac; Meneses, Alfredo; Carlton, Susan M.; Granados‐Soto, Vinicio

doi:10.1016/j.pain.2005.06.011

Cited by 89 publications

(57 citation statements)

References 49 publications

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“…Subcutaneous injection of formalin, a chemical irritant, into the rat's paw results in a reproducible biphasic response (Rocha-González et al 2005). The reaction in the first phase (phase 1, 0-5 minutes) is caused by the initial tissue injury and a direct activation of peripheral nociceptors by formalin.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Silva

Luft

Lunardelli

et al. 2015

An. Acad. Bras. Ciênc.

132

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Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The inflammatory response evoked by carrageenan and by croton oil was reduced through the pre-treatment of animals with LEO. In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to that observed for dexamethasone. In the formalin test, LEO consistently inhibited spontaneous nociception and presented a similar effect to that of tramadol. The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO and demonstrates its important therapeutic potential.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Silva

Luft

Lunardelli

et al. 2015

An. Acad. Bras. Ciênc.

132

View full text Add to dashboard Cite

show abstract

“…The application of 5-HT iontophoretically to the spinal dorsal horn generally inhibits nociceptive responses (11), but excitatory effects have also been reported less frequently (77). Since there are many inhibitory interneurons in the dorsal horn, the excitation produced by 5-HT on those inhibitory neurons may cause the dis-inhibition on the sensory transmission (78).…”

Section: Behavioral Studymentioning

confidence: 99%

Mechanisms for the Anti-nociceptive Actions of the Descending Noradrenergic and Serotonergic Systems in the Spinal Cord

2006

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Abstract. The sensation of pain plays a critical role as an alert and as a protection system against tissue damage from mechanical, chemical, and thermal stimuli. Despite the protective role of pain, the severity of pain sensation is markedly attenuated by the endogenous pain inhibitory systems that predominantly originate at the brain stem. Both behavioral and in vivo extracellular recording studies have sought the loci producing analgesia and clarification of the anti-nociceptive actions. Among those loci, the main descending systems to the spinal dorsal horn are noradrenergic and serotonergic. Although, in vivo studies have provided basic knowledge of these systems, the precise synaptic mechanisms underlying the analgesic actions have not yet been elucidated until recently. The newly developed in vitro slice and in vivo patchclamp recordings have disclosed the synaptic mechanisms of the noradrenergic and serotonergic effects at the level of spinal dorsal horn. This paper reviews the anti-nociceptive action of these systems, while particularly focusing on the electrophysiological aspects of the systems at the single neuron level in the spinal dorsal horn as well as their origins and responsible receptor subtypes.

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“…Therefore, microinjection of formalin was preceded by either local or spinal administration of SB-269970 and/or 5-HT and 5-CT. Local administration of SB-269970 significantly reduced 1% formalin-induced flinching, while local 5-HT or 5-CT augmented dose-dependently 0.5% formalin-induced nociceptive behavior, which was significantly reduced by SB-269970 [165]. So, activation of the 5-HT7 receptor in the paw induces nociceptive behavior and also mediates formalin-induced nociception.…”

Section: Painmentioning

confidence: 84%

Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives

et al. 2011

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Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser extent, agonists, however, are quite contradictory. In this review, we not only discuss in detail the role of the 5-HT7 receptor in the CNS but also propose some hypothetical models, which could explain the observed inconsistencies. These models are based on two novel concepts within the field of G protein-coupled receptors (GPCR), namely biphasic signaling and G protein-independent signaling, which both have been shown to be mediated by GPCR dimerization. This led us to suggest that the 5-HT7 receptor could reside in different dimeric contexts and initiate different signaling pathways, depending on the neuronal circuitry and/or brain region. In conclusion, we highlight GPCR dimerization and G protein-independent signaling as two promising future directions in 5-HT7 receptor research, which ultimately might lead to the development of more efficient dimer- and/or pathway-specific therapeutics.

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Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test

Cited by 89 publications

References 49 publications

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Mechanisms for the Anti-nociceptive Actions of the Descending Noradrenergic and Serotonergic Systems in the Spinal Cord

Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives

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