ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells
Julien Cicero,
Sarah Trouvilliez,
Martine Palma
et al.
Abstract:Background
Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition to reducing survival. The development of brain metastases is particularly harmful in triple-negative breast cancer (TNBC). To date, the mechanisms that induce brain metastasis in TNBC are poorly understood.
Methods
Using a human blood–brain barrier (BBB) in vitro model,… Show more
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