Promotor methylation: Does it affect response to therapy in chronic hepatitis C (G4) or fibrosis?

Zekri, Abdel-Rahman N.; Raafat, Ahmed; Elmasry, Suzan Hamdy; Bahnassy, Abeer A.; Saad, Yasmin; Dabaon, Hamed A.; El-Kassas, Mohamed; Shousha, Hend Ibrahim; Nassar, Auhood; EL-Dosouky, Mohamed Ale; Hussein, Nehal

doi:10.1016/s1665-2681(19)31251-7

Cited by 10 publications

(22 citation statements)

References 19 publications

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“…This is supported by the results of the study conducted by Zekri et al, in which they demonstrated that methylation of certain host genes increase with liver disease progression, from fibrosis to HCC [89]. Moreover, the same group of authors has been shown that methylation of certain tumor suppressor genes affect the response to the antiviral therapy [90]. Considering this, a better understanding of methylation changes and how they correlate with disease progression will help in finding novel biomarkers for early detection of HCC and its prevention.…”

Section: Host Genes Promoter Methylation Induced By Hcvmentioning

confidence: 60%

“…As authors reported, promoter methylation of MGMT gene appeared at higher frequencies in the NR than in the responders, which was explained by the fact that MGMT has an important role in protecting cells against DNA damage, via triggering DNA repair mechanisms [100]. On the other hand, the same group of authors has shown that RASSF1A methylation was significantly higher in HCV patients with mild fibrosis, which support the role of an intact RASSF1A gene in inducing the fibrogenesis in chronic HCV patients [90]. Another study by Hayashi et al reported that HCC patients with SVR have different molecular alterations compared to NR with continuous HCV infection [101].…”

Section: Hcv-encoded Proteins Inducing Host Genes Methylationmentioning

confidence: 92%

“…Iyer et al recorded high frequencies of p15, p16, APC, FHIT (fragile histidine triad), and E-cadherin promoter methylation in the plasma and liver tissue of HCV-associated HCC patients, with high concordance for all examined genes [99]. Zekri et al have shown that methylation of MGMT (O-6-methylguanine-DNA methyltransferase) gene can be used as a predictor of response to the antiviral therapy, while RASSF1A methylation status could be a marker of fibrosis severity [90]. As authors reported, promoter methylation of MGMT gene appeared at higher frequencies in the NR than in the responders, which was explained by the fact that MGMT has an important role in protecting cells against DNA damage, via triggering DNA repair mechanisms [100].…”

Section: Hcv-encoded Proteins Inducing Host Genes Methylationmentioning

confidence: 99%

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Hepatitis C: Host and Viral Factors Associated with Response to Therapy and Progression of Liver Fibrosis

Jovanović-Ćupić¹,

Božović²,

Krajnović³

et al. 2018

Hepatitis C - From Infection to Cure

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The goal of this study was to identify the baseline host and viral factors of response to antiviral therapy in patients with chronic hepatitis C. Compared with interferon/ribavirin therapy, new current direct-acting antiviral (DAA) combination regimens significantly increased rate of sustained virologic response (SVR) and shorter treatment durations, but is still limited by viral resistance, adverse effects, and high cost especially in developing countries. Human genetic factors and heterogeneity within the HCV genome may be associated with virologic treatment failure before and after antiviral therapy. Further, HCV infection may contribute to the development of HCV-related liver disease and hepatocarcinogenesis, through modulating genetic and epigenetic state of certain genes implicated in control of critical cellular pathways. Previous results confirm the importance of host and viral factors and virus-induced genetic and epigenetic changes in predicting outcome and treatment response.

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Section: Host Genes Promoter Methylation Induced By Hcvmentioning

confidence: 60%

Section: Hcv-encoded Proteins Inducing Host Genes Methylationmentioning

confidence: 92%

Section: Hcv-encoded Proteins Inducing Host Genes Methylationmentioning

confidence: 99%

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Hepatitis C: Host and Viral Factors Associated with Response to Therapy and Progression of Liver Fibrosis

Jovanović-Ćupić¹,

Božović²,

Krajnović³

et al. 2018

Hepatitis C - From Infection to Cure

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“…Our results showed a significant increase in the frequency of O6MGMT PM from CH (26%) to HCC (67.7%) providing an evidence that this gene could be used to differentiate between CH and HCC. We have also reported that O6MGMT PM is significantly higher in non-responder to antiviral therapy, and consequently O6MGMT could be used as a predictor for antiviral response [33]. Literature reviews shows different frequencies of O6MGMT PM in HCC ranging from 0% to 22-39% [34,35].…”

Section: Genes Methylation Could Be Used As a Biomarker For Diagnosismentioning

confidence: 81%

“…As for p15, the methylation frequency was 44.2% (92/208) in HCC, 33 Methylated (M); Unmethylated (U). Table 3.…”

Section: Increasing Dna Promoter Methylation Is Associated With Diseamentioning

confidence: 93%

The Molecular Background Associated with the Progression of Hepatitis C to Hepatocellular Carcinoma

Zekri¹,

Bahnassy²,

Abdellateif³

2018

Hepatitis C - From Infection to Cure

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Hepatocellular carcinoma (HCC) is a major health problem worldwide. The DNA PM of cancer-related genes plays an important role in the development and progression of HCC. The data reported in our studies provide evidence that PM of p73, p14, and O6-MGMT is associated with HCC, whereas PM of the APC gene is more common in chronic hepatitis (CH) cases. Thus, it could be used as a maker for early detection of HCV-induced chronic active hepatitis. A panel of four genes APC, p73, p14, and O6-MGMT independently affected the classification of cases into HCC and CH with accuracy (89.9%), sensitivity (83.9%), and specificity (94.7%). Also, the detection of PM of APC, FHIT, p15, p16, and E-cadherin in peripheral blood of HCV-infected patients is a highly sensitive and specific. Therefore, blood could be used as efficiently as tissue biopsies to assess PM of different genes. This could help in the follow-up of CH patients and early detection of HCC. We did not observe a significant difference in the methylation status according to the virus type HBV versus HCV. So, plasma DNA is a reliable resource for methylation studies in the future, irrespective of the type of hepatitis infection.

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Establishing a research production line in real-life settings: the case of Hepatitis C management in a viral hepatitis specialized Egyptian center

Kassas

Eltabbakh

Elbadry

et al. 2022

Current Medical Research and Opinion

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Promotor methylation: Does it affect response to therapy in chronic hepatitis C (G4) or fibrosis?

Cited by 10 publications

References 19 publications

Hepatitis C: Host and Viral Factors Associated with Response to Therapy and Progression of Liver Fibrosis

Hepatitis C: Host and Viral Factors Associated with Response to Therapy and Progression of Liver Fibrosis

The Molecular Background Associated with the Progression of Hepatitis C to Hepatocellular Carcinoma

Establishing a research production line in real-life settings: the case of Hepatitis C management in a viral hepatitis specialized Egyptian center

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