Promotion of the Stability of Lycopene by Liposomal formulations for Anti-aging Therapy

Luong, Hoang Van

doi:10.4172/2329-8847.1000e113

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…40) It was demonstrated that encapsulation of lycopene into the liposome improved not only its stability but also improved therapeutic effects against the oxidative stress-mediated aging process. 41) As gammaoryzanol is also susceptible to oxidation in the presence of oxygen from air, light, and heat, 42) we hypothesized that encapsulation of γ-oryzanol into a proper formulation might improve its chemical stability. Besides, liposomes can increase the therapeutic efficiency of encapsulated drugs compared to free drugs and protect them from enzymatic degradation and hydrolysis.…”

Section: Effects Of Liposomal Encapsulation On the Chemical Stability...mentioning

confidence: 99%

Nanoparticles Encapsulated γ-Oryzanol as a Natural Prodrug of Ferulic Acid for the Treatment of Oxidative Liver Damage

Ara,

Kogure

2023

Biological & Pharmaceutical Bulletin

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Antioxidants are promising therapeutics for treating oxidative stress-mediated liver diseases. Previously, we studied a potent natural antioxidant, ferulic acid, and developed a liposomal formulation of ferulic acid (ferulic-lipo) to improve its solubility. Ferulic-lipo significantly attenuated oxidative damage in the liver by inhibiting reactive oxygenase species (ROS). However, antioxidative liposomes must be less reactive with ROS prior to reaching the target sites to effectively neutralize existing ROS. But ferulic-lipo tends to be oxidized before reaching the liver. Besides, γ-oryzanol has been reported to decompose into ferulic acid in vivo; accordingly, we hypothesized that γ-oryzanol could be employed as a natural prodrug of ferulic acid to improve stability and antioxidative effectiveness. Therefore, in this study, we prepared a liposomal formulation of γ-oryzanol (γ-ory-lipo) and investigated its therapeutic effects in a CCl 4 -induced rat model of liver injury. We found that γ-ory-lipo has a higher chemical stability than does free γ-oryzanol. Although the antioxidative effect of γ-ory-lipo was lower than that of ferulic-lipo, pretreatment of the HepG2 cells with γ-ory-lipo improved the viability of CCl 4 -treated cells to a similar level as treatment with ferulic-lipo. γ-Oryzanol was shown to be converted into ferulic acid in vitro and in vivo. Furthermore, intravenous administration of γ-ory-lipo exhibited a similar effectiveness as ferulic-lipo against CCl 4 -induced hepatotoxicity, which should be the due to the conversion of γ-oryzanol into ferulic acid. These findings demonstrated that γ-ory-lipo could be a good natural prodrug of ferulic acid for eradicating its stability problem.

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Section: Effects Of Liposomal Encapsulation On the Chemical Stability...mentioning

confidence: 99%

Nanoparticles Encapsulated γ-Oryzanol as a Natural Prodrug of Ferulic Acid for the Treatment of Oxidative Liver Damage

Ara,

Kogure

2023

Biological & Pharmaceutical Bulletin

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Promotion of the Stability of Lycopene by Liposomal formulations for Anti-aging Therapy

Abstract: Aging Sci , an open access journal Volume 2 • Issue 3 • 1000e113 Jo u r n a l o f Agin g S c ie n ce

Cited by 1 publication

References 9 publications

Nanoparticles Encapsulated γ-Oryzanol as a Natural Prodrug of Ferulic Acid for the Treatment of Oxidative Liver Damage

Nanoparticles Encapsulated γ-Oryzanol as a Natural Prodrug of Ferulic Acid for the Treatment of Oxidative Liver Damage

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