Promotion of Second Intention Wound Healing by Emu Oil Lotion: Comparative Results with Furasin, Polysporin, and Cortisone

Politis, Michael J.; Dmytrowich, A

doi:10.1097/00006534-199812000-00020

Cited by 35 publications

(22 citation statements)

References 6 publications

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“…Emu oil was used by one specialist in this survey. There is evidence suggesting that emu oil, when combined with vitamin E, promotes faster healing with less pain and scarring in experimentally induced surgical wounds and burns in mice models, although further studies in dogs and people with ARID are needed 48,49 …”

Section: Discussionmentioning

confidence: 99%

Canine acute radiation dermatitis, a survey of current management practices in North America

Flynn

Lurie

2007

Vet Comparative Oncology

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Acute radiation-induced dermatitis (ARID) is a common sequela of radiation therapy in dogs. There is no consensus regarding ARID management in human medicine and the standard of care in veterinary medicine has not been reported. The objective was to report the practice standards for ARID management in dogs in North America. The design used was a questionnaire survey. Fifty-eight private and university teaching veterinary hospitals were contacted, 54 participated. The topical and oral medications used to treat ARID, prevent or treat bacterial infection, control pain and the indications for and timing of treatment initiation were the outcome measures. A minority of facilities (4/54, 7.5%) use exactly the same protocol regarding all parameters. There was agreement (>75% of facilities) with respect to the general use of oral antibiotics (77.8%), the need for pain control (92.6%) and the use of tramadol for pain control (76%), although the details of their use varied widely. There is a divergence of opinions regarding all details of ARID management in dogs except the general use of oral antibiotics and pain control medications.

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Section: Discussionmentioning

confidence: 99%

Canine acute radiation dermatitis, a survey of current management practices in North America

Flynn

Lurie

2007

Vet Comparative Oncology

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“…Neither study evaluated tissue cytokine levels as biomarkers of inflammation. Two other studies looked at the anti-inflammatory and wound-healing properties of emu oil when applied topically (3,4).…”

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Antagonism of croton oil inflammation by topical emu oil in CD‐1 mice

Yoganathan

Nicolosi

Wilson

et al. 2003

Lipids

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Emu oil is derived from the emu (Dromaius novaehollandiae), which originated in Australia, and has been reported to have anti-inflammatory properties. Inflammation was induced in anesthetized CD-1 mice by applying 50 microL of 2% croton oil to the inner surface of the left ear. After 2 h, the area was treated with 5 microL of emu, fish, flaxseed, olive, or liquified chicken fat, or left untreated. Animals were euthanized at 6 h postapplication of different oils, and earplugs (EP) and plasma samples were collected. Inflammation was evaluated by change in earlobe thickness, increase in weight of EP tissue (compared to the untreated ear), and induction in cytokines interleukin (IL)-1alpha and tumor necrosis factor-alpha (TNF-alpha) in EP homogenates. Although reductions relative to control (croton oil) were noted for all treatments, auricular thickness and EP weights were significantly reduced (-72 and -71%, respectively) only in the emu oil-treated group. IL-1alpha levels in homogenates of auricular tissue were significantly reduced in the fish oil (-57%) and emu oil (-70%) groups relative to the control group. The cytokine TNF-alpha from auricular homogenates was significantly reduced in the olive oil (-52%) and emu oil (-60%) treatment groups relative to the control group. Plasma cytokine levels were not changed by croton oil treatment. Although auricular thickness and weight were significantly correlated with each other (r = 0.780, P < 0.003), auricular thickness but not weight was significantly correlated with cytokine IL-alpha (r = 0.750, P < 0.006) and TNF-alpha (r = 0.690, P < 0.02). These studies indicate that topical emu oil has anti-inflammatory properties in the CD-1 mouse that are associated with decreased auricular thickness and weight, and with the cytokines IL-1alpha and TNF-alpha.

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“…Emu oil mainly consists of several types of fatty acids, carotenoids, flavones, polyphenols, tocopherol, and phospholipids (Brown et al 1995). Several studies have indicated that emu oil reduces the inflammatory response by suppressing the expression of pro-inflammatory cytokines, resulting in reduced oxidative injury and rapid wound healing and recovery (Politis and Dmytrowich 1998;Yoqanathan et al 2003;Bennett et al 2008). The anti-inflammatory effect of emu oil in canine skin infection requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial effects of topical skin cream containing natural oil mixtures against Staphylococcus pseudintermedius and Malassezia pachydermatis

Han¹,

Park²,

Kim³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:The objective of this study was to evaluate the in vitro efficacy of a topical skin cream containing a mixture of emu oil, jojoba oil, avocado oil, and tea tree oil against the canine skin pathogens Staphylococcus pseudintermedius and Malassezia pachydermatis. Three S. pseudintermedius isolates from dogs and a type strain of M. pachydermatis were used. Based on the standards of the Clinical and Laboratory Standards Institute, the minimal inhibitory concentration (MIC) and the minimal bactericidal/fungicidal concentration (MBC/MFC) were determined. In addition, microbial inactivation time was determined for both pathogens. The MICs against S. pseudintermedius and M. pachydermatis were 0.23% and 0.63%, while the MBC/MFCs were 7.5% and 5%, respectively. In assessments of the microbial inactivation time, after 12 h of incubation with the cream, the growth of both pathogens was completely inhibited. These results suggest that the skin cream tested here can be used as a substitute for generally used antibiotic/antifungal agents. Keywords: natural oil; Staphylococcus pseudintermedius; Malassezia pachydermatis; antimicrobial effectSupported by High Nature Ltd in 2014 (Grant No. 2013-A012-0038).Superficial skin infections such as superficial pyoderma and otitis externa are commonly encountered in veterinary practice and account for a significant number of antimicrobial prescriptions (Escher et al. 2011). Staphylococcus pseudintermedius and Malassezia pachydermatis are the most common pathogens isolated from pyoderma and otitis externa in dogs (Cafarchia et al. 2005;Fitzgerald 2009). In the last decade, resistance to antimicrobial agents has increased, particularly with the emergence and widespread dissemination of methicillin-resistant S. pseudintermedius in dogs as a result of the broad use of certain antimicrobial agents (Neu 1992;Kadlec and Schwarz 2013). The increased resistance to most available antimicrobial agents has created a need to identify alternative treatment strategies. As one possible alternative, the use of essential oils against various pathogens such as bacteria, virus, fungi, parasites, and insects has been widely evaluated (Weseler et al. 2002;Moon et al. 2006;Prabussenivasan et al. 2006;LaPlante et al. 2007;Wu et al. 2010;Freire et al. 2012;Valentine et al. 2012). These oils contain numerous constituents that contribute to the characteristic odour and medicinal effects, but they are not a usual choice for the treatment of infection, primarily because of the lack of scientific evidence of their efficacy.The objective of this study was to evaluate the in vitro efficacy of a topical skin cream containing a mixture of natural oils against the canine skin pathogens S. pseudintermedius and M. pachydermatis. MATERIAL AND METHODSTest materials. A topical skin cream (Dara cream ® , Koreai1, Kimpo, Korea) containing a mixture of emu oil, jojoba oil, avocado oil, and tea tree oil was evaluated. Ampicillin sodium salt and miconazole nitrate were purchased from Sigma-Aldrich Corp. (St. Louis, MO, USA) a...

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Promotion of Second Intention Wound Healing by Emu Oil Lotion: Comparative Results with Furasin, Polysporin, and Cortisone

Cited by 35 publications

References 6 publications

Canine acute radiation dermatitis, a survey of current management practices in North America

Canine acute radiation dermatitis, a survey of current management practices in North America

Antagonism of croton oil inflammation by topical emu oil in CD‐1 mice

Antimicrobial effects of topical skin cream containing natural oil mixtures against Staphylococcus pseudintermedius and Malassezia pachydermatis

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