Promotion effects of mono‐2‐ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF‐β signals

Fan, Pengju; Li, Zhen; Zuo, Chenchen; Fang, Man

doi:10.1002/cbf.3447

Cited by 12 publications

(5 citation statements)

References 42 publications

(47 reference statements)

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“…RES has the potential to suppress EMT via TGF-b1/Smads signaling, as proved by the up-regulating of E-cadherin and the downregulating of Snail and vimentin (16). Snail, a TGF-b1/Smad signaling pathway modulated gene (111,112), restrains the Ecadherin expression and triggers the EMT process (16). Furthermore, they also found that with the treatment of RES, TGF-b1-induced MMP2 and MMP9 decreased through expression analysis (16).…”

Section: Colorectal Cancermentioning

confidence: 96%

Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors

et al. 2021

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Epithelial-to-mesenchymal transition (EMT), a complicated program through which polarized epithelial cells acquire motile mesothelial traits, is regulated by tumor microenvironment. EMT is involved in tumor progression, invasion and metastasis via reconstructing the cytoskeleton and degrading the tumor basement membrane. Accumulating evidence shows that resveratrol, as a non-flavonoid polyphenol, can reverse EMT and inhibit invasion and migration of human tumors via diverse mechanisms and signaling pathways. In the present review, we will summarize the detailed mechanisms and pathways by which resveratrol and its analogs (e.g. Triacetyl resveratrol, 3,5,4’-Trimethoxystilbene) might regulate the EMT process in cancer cells to better understand their potential as novel anti-tumor agents. Resveratrol can also reverse chemoresistance via EMT inhibition and improvement of the antiproliferative effects of conventional treatments. Therefore, resveratrol and its analogs have the potential to become novel adjunctive agents to inhibit cancer metastasis, which might be partly related to their blocking of the EMT process.

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Section: Colorectal Cancermentioning

confidence: 96%

Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors

et al. 2021

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“…Synthetic surfactants can inhibit cell migration. Effective results were achieved by testing mono-2-ethyhexyl phthalate (MEPH) in the presence of A375 cells [38]. Compared to the commonly used chemotherapeutic agent ciprofloxacin, the results obtained from the wound healing assay are similar [39].…”

Section: Migration-scratch Assaymentioning

confidence: 99%

Evaluation of the Antitumor Activity of Quaternary Ammonium Surfactants

Hyla,

Jama,

Grzywacz

et al. 2023

IJMS

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Quaternary ammonium surfactants, due to their diverse chemical structure and their biological properties, can be used in medicine as DNA carriers, disinfectants, and antimicrobial and antitumor agents. In this study, using melanoma A375, colon adenocarcinoma HT-29 and normal human dermal fibroblast (NHDF) cells, we tested the hypothesis that the quaternary ammonium surfactants 2-dodecanoyloxyethyl)trimethylammonium bromide (DMM-11), 2-dodecanoyloxypropyl)trimethylammonium bromide (DMPM-11) and 2-pentadecanoyloxymethyl)trimethylammonium bromide (DMGM-14) act selectively against cancer cells. The results showed that these compounds led to the initiation of the apoptotic process of programmed cell death, as evidenced by the ratio of the relative expression of Bax protein to Bcl-2. The encapsulation of surfactants in liposomes allowed lower concentrations to be used. Moreover, encapsulation reduced their toxicity towards non-cancerous cells. The anticancer efficiency and apoptotic effect of the liposomal formulations with surfactants (DMM-11, DMPM-11 and DMGM-14) were higher than those of surfactant-free liposomes. Therefore, quaternary ammonium surfactant-loaded liposomes show significant potential as delivery vehicles for the treatment of melanoma and colon cancers. The use of nano-formulations offers the advantage of optimizing quaternary ammonium surfactant delivery for improved anticancer therapy.

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“…2) [79][80][81]. During cancer progression, tumor cells active the TGF-β pathway to mediate tumor growth, invasion, and metastasis [82]. TGF-β is a crucial mediator for FOXP3 in tumor infiltrating Tregs.…”

Section: Tumor and Treg Cell Contact Mechanismsmentioning

confidence: 99%

Targeting regulatory T cells for immunotherapy in melanoma

et al. 2021

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Regulatory T cells (Tregs) are essential in the maintenance of immunity, and they are also a key to immune suppressive microenvironment in solid tumors. Many studies have revealed the biology of Tregs in various human pathologies. Here we review recent understandings of the immunophenotypes and suppressive functions of Tregs in melanoma, including Treg recruitment and expansion in a tumor. Tregs are frequently accumulated in melanoma and the ratio of CD8+ T cells versus Tregs in the melanoma is predictive for patient survival. Hence, depletion of Tregs is a promising strategy for the enhancement of anti-melanoma immunity. Many recent studies are aimed to target Tregs in melanoma. Distinguishing Tregs from other immune cells and understanding the function of different subsets of Tregs may contribute to better therapeutic efficacy. Depletion of functional Tregs from the tumor microenvironment has been tested to induce clinically relevant immune responses against melanomas. However, the lack of Treg specific therapeutic antibodies or Treg specific depleting strategies is a big hurdle that is yet to be overcome. Additional studies to fine-tune currently available therapies and more agents that specifically and selectively target tumor infiltrating Tregs in melanoma are urgently needed.

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Promotion effects of mono‐2‐ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF‐β signals

Cited by 12 publications

References 42 publications

Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors

Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors

Evaluation of the Antitumor Activity of Quaternary Ammonium Surfactants

Targeting regulatory T cells for immunotherapy in melanoma

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