Promoting Weight Loss in Type II Diabetes

Brown, Sharon A.; Upchurch, Sandra L.; Anding, Roberta; Winter, Mary A.; Ramı́rez, Gilbert

doi:10.2337/diacare.19.6.613

Cited by 133 publications

(90 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings also document that older and younger adults may benefit similarly from interventions designed to improve diabetes self-management [3,20]. All of the moderator analyses should be viewed as exploratory and interpreted with caution since spurious findings are possible [21,22].…”

Section: Discussionsupporting

confidence: 52%

Metabolic effects of interventions to increase exercise in adults with type 2 diabetes

et al. 2007

View full text Add to dashboard Cite

Aims/hypothesis The aim of this meta-analysis was to integrate the results of primary research testing the effect of diabetes self-management interventions that included recommendations to increase exercise on metabolic outcomes among adults with type 2 diabetes. Materials and methods Extensive literature searching strategies were used to identify published and unpublished intervention studies that measured glycated haemoglobin outcomes. Primary study results were coded. Fixed-and random-effects meta-analytic procedures included moderator analyses.Results Data were synthesised across 10,455 subjects from 103 research reports. The overall mean weighted effect size for two-group comparisons was 0.29 (higher mean for treatment than control). This effect size is consistent with a difference in HbA 1c means of 0.45% (e.g. 7.38% for treatment subjects vs 7.83% for control subjects). For single-group studies, the overall mean weighted effect size was 0.32-0.34. Control group subjects experienced no improvement in metabolic control during participation in the studies. Interventions that targeted multiple health behaviours resulted in smaller effect size estimates (0.22) than interventions that focused only on exercise behaviours (0.45). Funded studies reported greater improvements in metabolic controls. Studies with a greater proportion of female subjects reported lower effect sizes. Baseline HbA 1c and BMI were unrelated to metabolic outcomes. Conclusions/interpretation These findings suggest that self-management interventions that include exercise recommendations improve metabolic control, despite considerable heterogeneity in the magnitude of the intervention effect. Interventions that emphasise exercise may be especially effective in improving metabolic control. Primary research testing interventions in randomised trials to confirm causal relationships would be constructive.Keywords Diabetes mellitus, type 2 . Exercise . Haemoglobin A, glycosylated . HbA 1c . Meta-analysis Abbreviations CLES common language effect size ES effect size GhB glycated haemoglobin Diabetologia (2007) 50:913-921

show abstract

Section: Discussionsupporting

confidence: 52%

Metabolic effects of interventions to increase exercise in adults with type 2 diabetes

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Weight loss due to successful treatment Promoting long-term weight loss in type 2 diabetic patients is difficult [29,30]. Even in successful intensive behaviourmodification programmes a pattern of weight regain is the predominant outcome [31,32], and diabetic patients demonstrate even poorer weight loss maintenance than their nondiabetic peers [33].…”

Section: Weight Loss Due To Calorie Loss In Glucosuriamentioning

confidence: 99%

Changes in patient weight and the impact of antidiabetic therapy during the first 5 years after diagnosis of diabetes mellitus

et al. 2006

View full text Add to dashboard Cite

Aims/hypothesis It is generally thought difficult for type 2 diabetic patients to lose weight. We monitored changes in patients' weight during the first 5 years after diabetes diagnosis in relation to initiation of antidiabetic treatment. Subjects and methods Data from 711 newly diagnosed diabetic patients aged 40 or over were analysed with a random-effect linear-regression model. Patients were included consecutively from a well-defined patient list in general practice. Results In 245 patients whose only treatment was advice on diet, an initial weight loss of 6 to 7 kg was largely maintained over 5 years. Patients receiving metformin (n=86) or sulfonylureas (n=330) maintained an average weight loss of 2 to 4 kg that was dependent on age and sex. Patients' weight did not change on initiation of treatment with sulfonylureas or metformin. Over 5 years, median HbA 1c increased from 7.0 to 7.8% (reference range 5.4-7.4%) in the diet-alone group. HbA 1c was approximately 1 percentage point higher for most of the other treatment groups. Conclusions/interpretation In newly diagnosed type 2 diabetic patients, long-term weight loss was common and weight loss was not affected by sulfonylurea treatment. The measurements in the study are taken from treatment results achieved in the general population of diabetic patients, who are rarely treated in secondary care and seldom the subject of research; the results thus indicate that weight reduction is a practicable treatment in diabetic patients.

show abstract

“…In patients with type 2 diabetes, lifestyle intervention has shown beneficial effects on traditional risk factors for cardiovascular disease, such as plasma glucose, blood lipids and blood pressure, although the effect may be modest and transient [21][22][23][24][25][26][27][28][29][30][31]. The evidence for an association between glycaemic control and systemic inflammation in subjects with diabetes seems conflicting [32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes

Aas¹,

Seljeflot

Torjesen

et al. 2006

Diabetologia

View full text Add to dashboard Cite

Promoting Weight Loss in Type II Diabetes

Abstract: Dietary strategies are most effective for promoting short-term weight loss in type II diabetes. A number of gaps exist in the extant literature- descriptions of subjects, interventions, or longitudinal outcomes beyond 12 months after intervention.

Cited by 133 publications

References 50 publications

Metabolic effects of interventions to increase exercise in adults with type 2 diabetes

Metabolic effects of interventions to increase exercise in adults with type 2 diabetes

Changes in patient weight and the impact of antidiabetic therapy during the first 5 years after diagnosis of diabetes mellitus

Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes

Contact Info

Product

Resources

About