Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties

Tu, Chenxi; Lu, Huidan; Zhou, Tong; Zhang, Wanying; Deng, Liwen; Cao, Wangbei; Yang, Zhijian; Wang, Zhong Lin; Wu, Xinyu; Ding, Jie; Xu, Feng; Gao, Changyou

doi:10.1016/j.biomaterials.2022.121597

Cited by 243 publications

(167 citation statements)

References 116 publications

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“…2B). More importantly, PCL-PLG could not only releases NO triggered by high levels H 2 O 2 , but also effectively depletes ROS, thus reducing the damage to cells and tissues caused by high ROS [33,34]. Subsequently, the release of NO decreases signi cantly with the depletion of H 2 O 2 and guanidine groups.…”

Section: Release Behavior and Biocompatibility Of Vesiclesmentioning

confidence: 94%

ROS-Responsive Sequential Release Systems with Excellent Biofilm Permeability for Enhanced Antibacterial and Regeneration-promoting Therapy in Periodontitis

Zeng

Shen

et al. 2023

Preprint

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Periodontitis is the sixth most common chronic inflammatory disease caused by plaque biofilms and closely related to many systemic diseases. In particular, the problems of deep lesion location and sequential treatment of antibacterial and pro-regenerative abilities need to be addressed. We created a novel ROS responsive system (CHX@PCL-PLG) for efficient therapy of refractory periodontitis based on a “three-birds-with-one-stone” strategy, which integrates the biofilm penetration, nitric oxide (NO) sterilization, and NO-mediated pro-angiogenic property into one system. The above system was fabricated by self-assembling vesicles formed by amphiphilic polymers containing poly-ε-caprolactone and guanidinated-poly-ε-lysine as carriers (PCL-PLG) loaded with chlorhexidine (CHX). CHX@PCL-PLG can efficiently penetrate into biofilm under the action of abundant guanidine groups on the vesicle’s surface. Subsequently, the guanidine groups of vesicles respond to the high level of ROS within the biofilm by releasing NO and CHX in a targeted manner to play a synergistic antibacterial and biofilm scavenging function. More importantly, following effective elimination all bacteria from the periodontal pockets, the residual guanidine groups could further produce trace amounts of NO, which promoted angiogenesis and epithelialization of the wound tissue to significantly facilitating wound healing. In conclusion, this study demonstrates that CHX@PCL-PLG makes full use of the characteristics of guanidine groups to significantly disrupt biofilms and promote tissue regeneration for the effective treatment of periodontitis as well as various biofilm-related diseases.

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Section: Release Behavior and Biocompatibility Of Vesiclesmentioning

confidence: 94%

ROS-Responsive Sequential Release Systems with Excellent Biofilm Permeability for Enhanced Antibacterial and Regeneration-promoting Therapy in Periodontitis

Zeng

Shen

et al. 2023

Preprint

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“…The tricarboxylic acid cycle (TCA) is the most efficient way for bacteria to obtain energy from the oxidation of sugars or other substances [ 93 ]. On this basis, Tu and coworkers prepared a hyperbranched poly-L-lysine (HBPL)-crosslinked hydrogel containing MnO 2 for the therapy of infected diabetic wound ( Figure 7 a) [ 94 ]. The transcriptome analysis showed that most genes encoding pathogenesis-associated toxins and regulating TCA were downregulated after treating with HBPL ( Figure 7 b–f).…”

Section: Planktonic Bacteriamentioning

confidence: 99%

Metal and Metal Oxide Nanomaterials for Fighting Planktonic Bacteria and Biofilms: A Review Emphasizing on Mechanistic Aspects

Sun

Wang

Dai

et al. 2022

IJMS

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The misuse and mismanagement of antibiotics have made the treatment of bacterial infections a challenge. This challenge is magnified when bacteria form biofilms, which can increase bacterial resistance up to 1000 times. It is desirable to develop anti-infective materials with antibacterial activity and no resistance to drugs. With the rapid development of nanotechnology, anti-infective strategies based on metal and metal oxide nanomaterials have been widely used in antibacterial and antibiofilm treatments. Here, this review expounds on the state-of-the-art applications of metal and metal oxide nanomaterials in bacterial infective diseases. A specific attention is given to the antibacterial mechanisms of metal and metal oxide nanomaterials, including disrupting cell membranes, damaging proteins, and nucleic acid. Moreover, a practical antibiofilm mechanism employing these metal and metal oxide nanomaterials is also introduced based on the composition of biofilm, including extracellular polymeric substance, quorum sensing, and bacteria. Finally, current challenges and future perspectives of metal and metal oxide nanomaterials in the anti-infective field are presented to facilitate their development and use.

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“…Oxygen is the most important nutrient for cell survival. Insufficient oxygen delivery prevents cell migration and angiogenesis and reduces cell growth and differentiation, thereby delaying wound healing ( Shiekh et al, 2020 ; Tu et al, 2022 ). Recently, a new technology is reported, which can transform the traditional gel dressing by adding freeze-dried nano-oxygen-containing powder to obtain a nano-sized oxygen-containing gel, which can deliver dissolved oxygen to the local wound surface ( Yang Z. et al, 2022 ).…”

Section: Application Of a Nanocomposite Hydrogel Delivery System To D...mentioning

confidence: 99%

Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers

Tong

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Diabetic ulcer is a serious complication of diabetes. Compared with that of healthy people, the skin of patients with a diabetic ulcer is more easily damaged and difficult to heal. Without early intervention, the disease will become increasingly serious, often leading to amputation or even death. Most current treatment methods cannot achieve a good wound healing effect. Numerous studies have shown that a nanocomposite hydrogel serves as an ideal drug delivery method to promote the healing of a diabetic ulcer because of its better drug loading capacity and stability. Nanocomposite hydrogels can be loaded with one or more drugs for application to chronic ulcer wounds to promote rapid wound healing. Therefore, this paper reviews the latest progress of delivery systems based on nanocomposite hydrogels in promoting diabetic ulcer healing. Through a review of the recent literature, we put forward the shortcomings and improvement strategies of nanocomposite hydrogels in the treatment of diabetic ulcers.

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Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties

Cited by 243 publications

References 116 publications

ROS-Responsive Sequential Release Systems with Excellent Biofilm Permeability for Enhanced Antibacterial and Regeneration-promoting Therapy in Periodontitis

ROS-Responsive Sequential Release Systems with Excellent Biofilm Permeability for Enhanced Antibacterial and Regeneration-promoting Therapy in Periodontitis

Metal and Metal Oxide Nanomaterials for Fighting Planktonic Bacteria and Biofilms: A Review Emphasizing on Mechanistic Aspects

Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers

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