Promoting Responsible Research and Innovation (RRI) During Brazilian Activities of Genomic and Epidemiological Surveillance of Arboviruses

Giovanetti, Marta; Alcântara, Luiz Carlos Júnior; Dorea, Alfredo Souza; Ferreira, Qesya Rodrigues; Marques, William de Almeida; Barros, José J.; Adelino, Talita; Tosta, Stephane; Fritsch, Hegger; Iani, Felipe Campos de Melo; Mares-Guia, Maria Angélica; Salgado, Álvaro; Fonseca, Vagner; Xavier, Joilson; Lopes, Élisson Nogueira; Soares, Gilson Carlos; Castro-Amarante, Maria Fernanda de; Azevedo, Vasco; Krüger, Alícia; Matta, Gustavo Corrêa; Paineiras-Domingos, Laisa Liane; Colonnello, Claudia; Filippis, Ana María Bispo de; Montesano, Carla; Colizzi, Vittorio; Barreto, Fernanda Khouri

doi:10.3389/fpubh.2021.693743

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…The document was the basis for the Unified Health System (SUS) creation, one of the largest and most complex public health systems worldwide 16 . Although several economic and political crises have assaulted the country over the past decades, SUS has enabled substantial progress toward Universal Health Coverage 17,18 . Furthermore, Brazil is a model for the world regarding epidemiological surveillance and vaccination, as the excellent management of several arboviruses' epidemics 19 and the populational coverage higher than 90% for acute infectious diseases reached by the Brazilian National Immunization Program 20 can illustrate.…”

Section: Discussionmentioning

confidence: 99%

Can SARS‐CoV‐2 screening in oral biopsies aid epidemiological surveillance?

Martins‐Chaves,

Diniz,

Miguita

et al. 2023

J Oral Pathology Medicine

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BackgroundThree years after the first confirmed COVID‐19 case in Brazil, the outcomes of Federal government omissions in managing the crisis and anti‐science stance heading into the pandemic have become even more evident. With over 36 million confirmed cases and nearly 700 000 deaths up to January 2023, the country is one of the hardest‐hit places in the world. The lack of mass‐testing programs was a critical broken pillar responsible for the quick and uncontrolled SARS‐CoV‐2 spread throughout the Brazilian population. Faced with this situation, we aimed to perform the routine SARS‐CoV‐2 screening through RT‐qPCR of oral biopsies samples to aid in the asymptomatic epidemiological surveillance during the principal outbreak periods.MethodsWe analyzed 649 formalin‐fixed paraffin‐embedded oral tissue samples from five important oral and maxillofacial pathology laboratories from the north, northeast, and southeast geographic regions of Brazil. We also sequenced the whole viral genome of positive cases to investigate SARS‐CoV‐2 variants.ResultsThe virus was detected in 9/649 analyzed samples, of which three harbored the Variant of Concern Alpha (B.1.1.7).ConclusionAlthough our approach did not value aiding asymptomatic epidemiological surveillance, we could successfully identify a using FFPE tissue samples. Therefore, we suggest using FFPE tissue samples from patients who have confirmed diagnosis of SARS‐CoV‐2 infection for phylogenetic reconstruction and contraindicate the routine laboratory screening of these samples as a tool for asymptomatic epidemiological surveillance.

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Section: Discussionmentioning

confidence: 99%

Can SARS‐CoV‐2 screening in oral biopsies aid epidemiological surveillance?

Martins‐Chaves,

Diniz,

Miguita

et al. 2023

J Oral Pathology Medicine

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“…Education is the basis for technology transfer and capacity building, enabling the dissemination and application of knowledge. 21 During VEME, in addition to the participation of professors who are experts on that field and internationally recognized for their work, the classes were based on a practical learning approach.…”

Section: Discussionmentioning

confidence: 99%

Technology transfer during the COVID-19 pandemic: report on the first face-to-face practical training course in Brazil

Barreto,

Santos,

Giovanetti

et al. 2023

Epidemiol. Serv. Saúde

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The objective of this report was to describe the first face-to-face course aimed at training public health professionals in performing real-time genomic surveillance during the pandemic period. Experience report on a theoretical-practical course focusing on genomic research and surveillance, including mobile sequencing technologies, bioinformatics, phylogenetics and epidemiological modeling. There were 162 participants in the event and it was the first major face-to-face training course conducted during the COVID-19 epidemic in Brazil. No cases of SARS-CoV-2 infection was detected among the participants at the end of the event, suggesting the safety and effectiveness of all safety measures adopted. The results of this experience suggest that it is possible to conduct professional training safely during pandemics, as long as all safety protocols are followed.

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“…In Africa, neglected arboviruses like CHIKV can cause significant epidemics, yet our understanding of its impact, distribution, and viral heterogeneity remains limited. Historically, public health responses and resources have predominantly been directed toward malaria prevention and control [121]. Understanding the genetic diversity of CHIKV in Africa is essential for advising effective public health strategies for disease surveillance and outbreak control tailored to the continent and its regions.…”

Section: Challenges and Gaps In Chikv Surveillance In Africamentioning

confidence: 99%

Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

Ramphal,

Tegally,

San

et al. 2024

Preprint

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The Chikungunya virus (CHIKV) poses a significant global public health concern, especially in Africa. Since its first isolation in Tanzania in 1953, CHIKV has caused recurrent outbreaks, challenging healthcare systems in low-resource settings. Recent outbreaks in Africa highlight the dynamic nature of CHIKV transmission and the challenges of underreporting and underdiagnosis. Here, we review literature and analyze publicly available cases, outbreaks, and genomic data providing insights into the epidemiology, genetic diversity, and transmission dynamics of CHIKV in Africa. Our analyses reveal the circulation of geographically distinct CHIKV genotypes, with certain regions experiencing a disproportionate burden of disease. Phylogenetic analysis of sporadic outbreaks in West Africa suggests repeated emergence of the virus through enzootic spillover, which is markedly different from inferred transmission dynamics in East Africa, where the virus is often introduced from Asian outbreaks, including the recent reintroduction of the Indian Ocean lineage from the Indian subcontinent to east Africa. Furthermore, there is limited evidence of viral movement between these two regions. Understanding the history and transmission dynamics of outbreaks is crucial for public health planning. Despite advances in surveillance and research, diagnostic and surveillance challenges persist. This review and secondary analysis highlight the importance of ongoing surveillance, research, and collaboration to mitigate the burden of CHIKV in Africa and improve public health outcomes.

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Promoting Responsible Research and Innovation (RRI) During Brazilian Activities of Genomic and Epidemiological Surveillance of Arboviruses

Cited by 6 publications

References 16 publications

Can SARS‐CoV‐2 screening in oral biopsies aid epidemiological surveillance?

Can SARS‐CoV‐2 screening in oral biopsies aid epidemiological surveillance?

Technology transfer during the COVID-19 pandemic: report on the first face-to-face practical training course in Brazil

Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

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