Promoting resolution in kidney disease

Doyle, Ross; Godson, Catherine; Brennan, Eoin

doi:10.1097/mnh.0000000000000558

Cited by 3 publications

(2 citation statements)

References 89 publications

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“…There is increasing evidence, that Omega-3 fatty acids are crucial in resolving inflammatory responses as substrates for the endogenic production of specialized pro-resolving mediators (resolvins, protectins, and maresins)-stopping inflammation and giving way to tissue reparation (22,23). Priante et al (24) provided a number of mechanism how n-3 PUFAs counteract renal inflammation and fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Blood Omega-3 Fatty Acids Are Inversely Associated With Albumin-Creatinine Ratio in Young and Healthy Adults (The Omega-Kid Study)

Filipovic

Reiner

Rittirsch

et al. 2021

Front. Cardiovasc. Med.

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Background: Omega-3 fatty acids are associated with a lower risk of cardiovascular disease (CVD) and with beneficial effects on CV risk factors. The albumin-creatinine ratio (ACR) is a risk factor for CVD, all-cause mortality and accelerated glomerular filtration rate (GFR) decline in the general population. We aimed to investigate the association between n-3 PUFAS and ACR in heathy individuals with preserved GFR.Design and Methods: The present cross-sectional analysis is part of the GAPP study, a population-based cohort of healthy adults aged 25–41 years. Individuals with known CVD, diabetes, or a BMI >35 kg/m2 were excluded. eGFR was calculated according to the combined Creatinine/Cystatin C CKD-EPI formula. ACR was obtained from a fasting morning urine sample. The Omega-3 Index (relative amount of EPA and DHA of total fatty acids in %) was obtained from whole blood aliquots.Results: Overall, 2001 participants (median age 37 years IQR 31; 40, 53% female) were included in this analysis. Median Omega-3 Index was 4.59 (IQR 4.06; 5.25) and median eGFR 111 ml/min/1.73 m2 (IQR 103; 118). Median ACR was 0.14 mg/mmol (IQR 0; 0.43). We found a significant inverse association of the Omega-3 Index with ACR (ratio 0.84, 95%CI 0.73–0.96; p = 0.011) which remained after comprehensive adjustment (ratio 0.86, 95%CI 0.74–1.00; p = 0.048). No association of the Omega-3 Index with eGFR was found. The adjusted difference in eGFR per 1-unit increase in Omega3-Index was −0.21 (95%CI −0.76; 0.35; p = 0.47).Conclusions: A higher Omega-3 Index was significantly associated with lower ACR in this young and healthy population with preserved eGFR. Omega-3 fatty acids may exhibit cardio- and nephroprotective effects in healthy individuals through modulation of ACR.

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Section: Discussionmentioning

confidence: 99%

Blood Omega-3 Fatty Acids Are Inversely Associated With Albumin-Creatinine Ratio in Young and Healthy Adults (The Omega-Kid Study)

Filipovic

Reiner

Rittirsch

et al. 2021

Front. Cardiovasc. Med.

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“…58 59 In addition, low-intensity shockwave therapy can improve or even reverse the microvascular loss, ischemia, and inflammation exhibited by kidney disease, ultimately slowing the progression of CKD. 60 In the meantime, gene therapy, 61 CRISPR gene-editing techniques, 62 and fatty acid-derived specialized procatabolic mediators, and other targeted therapies for inflammation 63 have begun to emerge as potential treatments. However, based on traditional experience and their multitargeting characteristics, natural products, such as Ganoderma lucidum , 64 should increasingly be considered an alternative source of treatment for kidney disease.…”

Section: The Possible Protective Effect Of Resveratrolmentioning

confidence: 99%

The Mechanism of Hyperoxia-Induced Neonatal Renal Injury and the Possible Protective Effect of Resveratrol

2022

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With recent advances in neonatal intensive care, preterm infants are surviving into adulthood. Nonetheless,epidemiological data on the health status of these preterm infants has begun to reveal a worrying theme; prematurity and the supplemental oxygen therapy these infants receive after birth appear to be risk factors for kidney disease in in adulthood, affecting their quality-of-life. As the incidence of chronic kidney disease and the survival time of preterm infants both increase, the management of hyperoxia-induced renal disease is becoming increasingly relevant to neonatologists. The mechanism of this increased risk is currently unknown, but prematurity itself and the hyperoxia exposure after birth may predispose to disease by altering the normal trajectory of kidney maturation. This article reviews altered renal reactivity due to hyperoxia, the possible mechanisms of renal injury due to hyperoxia, and the role of resveratrol in renal injury.

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Promoting resolution in kidney disease

Cited by 3 publications

References 89 publications

Blood Omega-3 Fatty Acids Are Inversely Associated With Albumin-Creatinine Ratio in Young and Healthy Adults (The Omega-Kid Study)

Blood Omega-3 Fatty Acids Are Inversely Associated With Albumin-Creatinine Ratio in Young and Healthy Adults (The Omega-Kid Study)

The Mechanism of Hyperoxia-Induced Neonatal Renal Injury and the Possible Protective Effect of Resveratrol

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