Promoting new concepts of skincare via skinomics and systems biology—From traditional skincare and efficacy‐based skincare to precision skincare

Jiang, Biwang; Jia, Yan; He, Congfen

doi:10.1111/jocd.12663

Cited by 3 publications

(13 citation statements)

References 54 publications

(48 reference statements)

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“…Finally, the different properties of skin that are related and which influence the appearance of undesirable clinical signs, evidence the necessity of a multifactorial approach for the effective improvement of oily skin in different facial regions (Jiang et al, 2018). The development of multifunctional cosmetic products that promote control of skin oils, regulate the keratinization process, improve micro relief and better structure the epidermis and dermis, will enable not only the improvement of oily skin conditions but will also improve or reduce the clinical signs that are a result of excessive oiliness, which are a major cause for concern and which results in a relentless search for cosmetic and dermatological products that address these issues (Wu et al, 2013; de Melo and Maia Campos, 2018).…”

Section: Resultsmentioning

confidence: 99%

Use of Advanced Imaging Techniques for the Characterization of Oily Skin

2019

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Excessively oily skin leads to clinical signs that cause discomfort to patients, such as excessive shine, enlarged pores, acne, and an imbalance of the hydrolipidic layer. In this context, a constant demand for the research and development of products that prevent these features, has been noted in the field of cosmetics and dermatology. Thus, the objective of this study is to evaluate the cutaneous characteristics of oily skin due an excessive production of sebum through biophysical and skin imaging techniques. 19 participants with different skin types were selected and the following parameters were evaluated: pore count, determination of the number of sebaceous glands and amount of sebum in infundibulum, determination of cutaneous microrelief, count of comedones, evaluation of epidermis thickness, characterization of the cellular, and comedone size and its characteristics. These evaluations were done through biophysical and skin imaging techniques. The obtained results showed that different regions of the face presented different characteristics related to oiliness, quantity, and the appearance of pores and comedones. The malar region had a lower epidermis thickness and a larger number of large pores. Moreover, in this region excessive sebum production, which can be related to pores, not comedones, was noted. The nose region presented higher sebum content in the infundibulum and lower active sebaceous glands, showing a higher activity of sebaceous production in this region. The chin region presented a positive correlation between the sebum content, roughness parameter and the number of pores and comedones. As different skin properties are related and influence the appearance of undesirable clinical signs, we identified the need for a multifactorial approach for the effective treatment of oily skin. The rational development of multifunctional cosmetic products that promote the control of oily skin, that regulate the keratinization process, improve the microrelief and leads to a better epidermis and dermis structure, will not only improve oily skin conditions but will also allow for the reduction or disappearance of clinical signs that result from excessive oiliness, all of which causes concern and results in a relentless search for cosmetic and dermatological products that address the unaesthetic nature of these conditions.

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Section: Resultsmentioning

confidence: 99%

Use of Advanced Imaging Techniques for the Characterization of Oily Skin

2019

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“…The application of systems biology allows studying the functional variation of molecules and their interactions in cells, tissues, organs, and organisms, using systematic quantification methods thanks to the application of mathematical models [ 6 ]. These considerations are fully reflected in the study of the microbiome, now considered a leading player in maintaining the state of health of human beings.…”

Section: Integrative Multiomics Approach To Skinmentioning

confidence: 99%

“…In this context, the study of the by-products of microbial metabolism, through metabolomics, can be useful in clarifying with greater precision the high complexity of the microbe-host-environment interaction. In fact, it is common that in the presence of the same skin problem, if the skin conditions are different, even simply due to the geographical area of origin, the reactions to a dermatological product are different [ 6 ]. Therefore, following the systems biology paradigm, an effective study strategy should integrate at least the main multi-omics data from metabolomics, lipidomics, and skin microbiomics not only in an attempt to highlight potential differential biomarkers but also to evaluate the possible interaction between them, in order to verify their biological significance.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, following the systems biology paradigm, an effective study strategy should integrate at least the main multi-omics data from metabolomics, lipidomics, and skin microbiomics not only in an attempt to highlight potential differential biomarkers but also to evaluate the possible interaction between them, in order to verify their biological significance. From this perspective, a nascent field of study is represented by skinomics, including not only metabolomics, lipidomics, and microbiomics but also genomics, proteomics, and skin transcriptomics, which through multivariate statistical methods such as PLS-DA, PCA, support vector machine, and random forest, aims to identify the differential metabolites and substances between normal and diseased skin [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Integrative Multiomics Approach to Skin: The Sinergy between Individualised Medicine and Futuristic Precision Skin Care?

Dessì,

Pintus,

Fanos

et al. 2024

Metabolites

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The skin is a complex ecosystem colonized by millions of microorganisms, the skin microbiota, which are crucial in regulating not only the physiological functions of the skin but also the metabolic changes underlying the onset of skin diseases. The high microbial colonization together with a low diversity at the phylum level and a high diversity at the species level of the skin is very similar to that of the gastrointestinal tract. Moreover, there is an important communication pathway along the gut–brain–skin axis, especially associated with the modulation of neurotransmitters by the microbiota. Therefore, it is evident that the high complexity of the skin system, due not only to the genetics of the host but also to the interaction of the host with resident microbes and between microbe and microbe, requires a multi-omics approach to be deeply understood. Therefore, an integrated analysis, with high-throughput technologies, of the consequences of microbial interaction with the host through the study of gene expression (genomics and metagenomics), transcription (transcriptomics and meta-transcriptomics), and protein production (proteomics and meta-proteomics) and metabolite formation (metabolomics and lipidomics) would be useful. Although to date very few studies have integrated skin metabolomics data with at least one other ‘omics’ technology, in the future, this approach will be able to provide simple and fast tests that can be routinely applied in both clinical and cosmetic settings for the identification of numerous skin diseases and conditions. It will also be possible to create large archives of multi-omics data that can predict individual responses to pharmacological treatments and the efficacy of different cosmetic products on individual subjects by means of specific allotypes, with a view to increasingly tailor-made medicine. In this review, after analyzing the complexity of the skin ecosystem, we have highlighted the usefulness of this emerging integrated omics approach for the analysis of skin problems, starting with one of the latest ‘omics’ sciences, metabolomics, which can photograph the expression of the genome during its interaction with the environment.

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“…Recently, a precision approach has been developed that uses biomarkers. 6 The use of lasers is an alternative to skincare-using creams. Laser technology has evolved dramatically in the last six decades to use for cosmetic purposes.…”

Section: Introductionmentioning

confidence: 99%

Direct and Indirect Roles of Men in Determining Women Decision to Use Laser Procedures for Skin Care

Teresa¹

2023

CCID

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Laser procedures for skin care is becoming increasingly popular and used by the global community and affect many aspects of human life. However, there is very little research on the role of men in women's decision to follow this dermatological procedure. This study aimed to identify the role of men in motivating women to choose laser-based procedure. A systematic literature review research design was applied in this study. A total of 27 papers were obtained by searching PubMed Central for the 2013-2022 editions. The extraction of samples and the motivation of patients or research respondents in choosing laser procedures for cosmetic treatments were conducted to obtain clues about the role of men in making these decisions. Only six studies explicitly reveal the role of men as motivators of women to perform laser-based dermatological procedures. Four of these six studies were conducted in Asia in countries with a high degree of collectivism. The remaining two studies reveal a minor role for men in women's motivation to choose dermatological procedures. Other studies only indirectly implicate the role of men through intrasexual competition, increased selfesteem, and the needs of the world of work. Limitations of the study lies in the non-specificity of the study sample in the female population, laser-based treatments, and the role of men in motivating women. The role of men in motivating women to perform laserbased skin care procedures is stated explicitly in collectivist cultures while only implicitly in individualist cultures. These findings indicate that the strategy of utilizing the added value of men to laser treatment procedures should be directed at the relationship between men and women in real terms in collective cultured countries.

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Promoting new concepts of skincare via skinomics and systems biology—From traditional skincare and efficacy‐based skincare to precision skincare

Cited by 3 publications

References 54 publications

Use of Advanced Imaging Techniques for the Characterization of Oily Skin

Use of Advanced Imaging Techniques for the Characterization of Oily Skin

Integrative Multiomics Approach to Skin: The Sinergy between Individualised Medicine and Futuristic Precision Skin Care?

Direct and Indirect Roles of Men in Determining Women Decision to Use Laser Procedures for Skin Care

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