Promoter methylation of transient receptor potential melastatin-related 7 (TRPM7) predicts a better prognosis in patients with Luminal A breast cancers

Wang, Yuanyuan; Lu, Rong; Chen, Pu; Cui, Ruixia; Ji, Meiju; Zhang, Xiaozhi; Hou, Peng; Qu, Yiping

doi:10.1186/s12885-022-10038-z

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…A recent study has demonstrated that TRPM7 was highly expressed in the luminal A subtype of breast cancer. Nevertheless, the promoter methylation of TRMP7 was associated with a better prognosis of the disease [160].…”

Section: Breast Cancermentioning

confidence: 96%

The Role of TRPM7 in Oncogenesis

Köles,

Ribiczey,

Szebeni

et al. 2024

IJMS

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This review summarizes the current understanding of the role of transient receptor potential melastatin-subfamily member 7 (TRPM7) channels in the pathophysiology of neoplastic diseases. The TRPM family represents the largest and most diverse group in the TRP superfamily. Its subtypes are expressed in virtually all human organs playing a central role in (patho)physiological events. The TRPM7 protein (along with TRPM2 and TRPM6) is unique in that it has kinase activity in addition to the channel function. Numerous studies demonstrate the role of TRPM7 chanzyme in tumorigenesis and in other tumor hallmarks such as proliferation, migration, invasion and metastasis. Here we provide an up-to-date overview about the possible role of TRMP7 in a broad range of malignancies such as tumors of the nervous system, head and neck cancers, malignant neoplasms of the upper gastrointestinal tract, colorectal carcinoma, lung cancer, neoplasms of the urinary system, breast cancer, malignant tumors of the female reproductive organs, prostate cancer and other neoplastic pathologies. Experimental data show that the increased expression and/or function of TRPM7 are observed in most malignant tumor types. Thus, TRPM7 chanzyme may be a promising target in tumor therapy.

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Section: Breast Cancermentioning

confidence: 96%

The Role of TRPM7 in Oncogenesis

Köles,

Ribiczey,

Szebeni

et al. 2024

IJMS

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show abstract

“…In xenografts, immunodeficient Rag2−/−IL2rg−/− mice, harboring human MDA‐MB‐231 cells, these high TRPM7 levels were required for cancer proliferation and metastasis ( 294 ). More recently, it has been described that the increased expression of TRPM7 channels predicts reduced survival in patients suffering from Luminal A breast cancer ( 295 ). The authors found that the methylation frequency of the channel has a mean of 42.7% in the whole cohort, while it is much lesser in Luminal A cancer versus other subtypes (33.3% vs. 45.7% in Luminal B, 46.9% in Her2+, and 51.3% in Basal-like).…”

Section: Trpm Channels: Characteristics and Functionsmentioning

confidence: 99%

On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications

et al. 2023

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The transient melastatin receptor potential (TRPM) ion channel subfamily functions as cellular sensors and transducers of critical biological signal pathways by regulating ion homeostasis. Some members of TRPM have been cloned from cancerous tissues, and their abnormal expressions in various solid malignancies have been correlated with cancer cell growth, survival, or death. Recent evidence also highlights the mechanisms underlying the role of TRPMs in tumor epithelial-mesenchymal transition (EMT), autophagy, and cancer metabolic reprogramming. These implications support TRPM channels as potential molecular targets and their modulation as an innovative therapeutic approach against cancer. Here, we discuss the general characteristics of the different TRPMs, focusing on current knowledge about the connection between TRPM channels and critical features of cancer. We also cover TRPM modulators used as pharmaceutical tools in biological trials and an indication of the only clinical trial with a TRPM modulator about cancer. To conclude, the authors describe the prospects for TRPM channels in oncology.

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“…In breast cancer, TRPM7 is associated with poor prognosis, cell migration and metastasis [ 67 , 68 ], and its high methylation profile is associated with a good prognosis [ 69 ]. However, its role in cell proliferation is not completely clear, as it seems to highly contribute to the proliferation of the adenocarcinoma cell line MCF7 [ 70 ] but not the triple-negative breast cancer cell line MDA-MB-231 [ 71 ].…”

Section: Mechanoreceptors In Cancermentioning

confidence: 99%

Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer

Otero-Sobrino,

Blanco-Carlón,

Navarro-Aguadero

et al. 2023

IJMS

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Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical extracellular and intracellular changes, translating them into cation influx to adapt and respond to these physical cues. All cells in the organism are mechanosensitive, and these physical cues have proven to have an important role in regulating proliferation, cell fate and differentiation, migration and cellular stress, among other processes. Indeed, the mechanical properties of the extracellular matrix in cancer change drastically due to high cell proliferation and modification of extracellular protein secretion, suggesting an important contribution to tumor cell regulation. In this review, we describe the physiological significance of mechanosensitive ion channels, emphasizing their role in cancer and immunity, and providing compelling proof of the importance of continuing to explore their potential as new therapeutic targets in cancer research.

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Promoter methylation of transient receptor potential melastatin-related 7 (TRPM7) predicts a better prognosis in patients with Luminal A breast cancers

Cited by 4 publications

References 56 publications

The Role of TRPM7 in Oncogenesis

The Role of TRPM7 in Oncogenesis

On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications

Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer

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