Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma

Cho, Bomsoo; Lee, Hansoo; Jeong, Shinwu; Bang, Yung Jue; Lee, Hyun Joo; Hwang, Kyu Sang; Kim, Hae Yeong; Lee, Yun Sil; Kang, Gyeong Hoon; Jeoung, Dooil

doi:10.1016/s0006-291x(03)01121-5

Cited by 119 publications

(89 citation statements)

References 42 publications

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“…Antibody response was detected in 5.1% (four of 79) of the HCC patients, 8.3% (three of 36) of the gastric cancer patients and 7.3% (three of 41) of the patients with colorectal cancer. Thus, we have confirmed the high expression of CAGE mRNA in gastric cancer as reported by Cho et al (2002Cho et al ( , 2003, and revealed the intermediate expression of CAGE in HCC and colorectal cancer. We also demonstrated that CAGE was immunogenic to elicit antibody response in cancer patients.…”

Section: Discussionsupporting

confidence: 87%

“…A total of 30 antigens reactive with serum IgG from HCC patients were identified, which include 14 antigens reported to be involved in tumorigenesis or suspected to be related to tumour progression. Of these, one is CT antigen (CAGE), which was first reported to be expressed in gastric cancer by Cho et al (2002) and found to be hypomethylated in the majority specimens of human HCC (Cho et al, 2003). Intriguingly, none of the 30 antigens overlapped with the antigens detected by the other two groups (Stenner-Liewen et al, 2000;Uemura et al, 2003), and only one of them (HCA58) was identified in our previous report .…”

Section: Discussionmentioning

confidence: 73%

“…To ensure whether CAGE was expressed in cirrhosis tissues, 19 cirrhosis samples were collected for further analysis of the expression of CAGE mRNA, and two of the 19 samples were observed to be positive (data not shown). A recent study by Cho and collegues has provided evidence for promoter hypomethylation of CAGE in the premalignant stage of gastric carcinoma and HCC (Cho et al, 2003). It is perceivable that CAGE is associated with the progression of tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

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Identification and analysis of tumour-associated antigens in hepatocellular carcinoma

Wang

et al. 2005

Br J Cancer

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To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libraries (SEREX). The mRNA expression patterns of 14 of these 30 antigens were altered in cancer as further revealed by cDNA microarray, with upregulation for nine and downregulation for five antigens. One of the upregulated antigens was cancer-testis (CT) antigen (CAGE), which had been previously reported to be expressed exclusively in normal gametogenic tissues and aberrantly expressed in a variety of cancer cells. In our study, CAGE mRNA was expressed in 39.4% of HCC patients, 73.3% of patients with gastric cancer and 30.8% of patients with colorectal cancer. Antibodies against CAGE protein were detected in approximately 5.1% of the sera from HCC patients, 8.3% of that from gastric cancer patients and 7.3% of that from colorectal cancer patients. The relative high incidence of CAGE in cancer cells makes it a potential target for vaccine design. Another antigen of great interest is transgelin 2. The overexpression of transgelin 2 mRNA in a large per cent (69%) of HCC points to its potential as a diagnostic marker for HCC.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Identification and analysis of tumour-associated antigens in hepatocellular carcinoma

Wang

et al. 2005

Br J Cancer

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“…Hyperplasia is considered a potential premalignant precursor lesion which usually precedes cancer. 21 This is analogous to CAGE, a CT antigen, which is expressed in premalignant stage of gastric carcinoma 22 and associated with tumor progression.…”

Section: Discussionmentioning

confidence: 99%

Plac1 is a tumor‐specific antigen capable of eliciting spontaneous antibody responses in human cancer patients

Dong

Peng

et al. 2008

Intl Journal of Cancer

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Immunoselection and tumor evasion constitutes one of the major obstacles in cancer immunotherapy. A potential solution to this problem is the development of polyvalent vaccines, and the identification of more tumor-specific antigens is a prerequisite for the development of cancer vaccines. To identify novel tumor-specific antigens, suppression subtractive hybridization (SSH) was performed to isolate genes differentially expressed in human hepatocellular cancer (HCC) tissues. PLAC1 (PLACenta-specific 1) was one of the genes identified highly expressed in HCC tissues but not in paired noncancerous tissues. Further analyses revealed its expression in several other types of cancer tissues as well as tumor cell lines, but not in normal tissues except for placenta. Among HCC samples tested, 32% (22/69) showed PLAC1 mRNA expression while the protein was detected in 23.3% (7/30). A serological survey revealed that 3.8% (4/101) of HCC patients had anti-PLAC1 antibody response, suggesting the immunogenicity of PLAC1 in HCC patients. PLAC1 represents a new class of tumor associated antigen with restricted expression in placenta and cancer tissues, that may serve as a target for cancer vaccination.

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“…Aunque este mecanismo fue identificado hace más de 30 años 49 , no fue considerado sino hasta hace poco tiempo atrás. En efecto, en varias publicaciones se ha redescubierto a la hipometilación como un mecanismo de activación de oncogenes [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66] . Estas publicaciones indican que la hipometilación de genes específicos, tales como MAGE 51 , synuclein-alfa 52 , MUC2 55 , maspin 57 , CAGE 56 y family A melanoma antigen 61 ocurriría en las etapas avanzadas del cáncer.…”

Section: Hipometilación Del Adn Y Cáncer Gástricounclassified

Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores

2013

Rev. méd. Chile

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Epigenetics in the pathogenesis and early detection of gastric cancerpuc.cl E l cáncer gástrico es la primera causa de muerte por enfermedades neoplásicas en Chile y la segunda en el mundo 1,2 . A pesar de los avances en el tratamiento y una disminución de sus lesiones precursoras 3,4 , recientes publicaciones sugieren un probable aumento de su mortalidad, particularmente en población joven 5 . Estas observaciones, en conjunto con proyecciones de la mortalidad global para los próximos 20 años, sugieren que el cáncer gástrico ocupará la décima causa global de muerte para la década del 2030 6 . El cáncer gástrico se puede clasificar según aspectos clínicos, endoscópicos o histológicos 7-13 . La clasificación más utilizada es la propuesta por Lauren 13 , la cual, según parámetros histológicos, define dos tipos de cáncer gástrico: el intestinal y el difuso. El primero se caracteriza por la formación de estructuras glandulares que semejan la mucosa colónica y que está precedida por una secuencia de lesiones muy bien caracterizadas por Correa y col. 14,15 . Por otra parte, el cáncer gástrico de tipo difuso, no forma estructuras histológicas y en consecuencia no tiene lesiones precursoras reconocidas 16 . Una particularidad importante de la clasificación de Lauren es que ha sido muy útil para estudiar el rol del ambiente, en particular en la variante intestinal 15 . En este sentido, las lesiones precancerosas han demostrado progresar de forma dinámica, desde la gastritis crónica superficial, gastritis crónica atrófica, metaplasia intestinal y finalmente displasia. Estos eventos constituyen las bases del "modelo humano de cáncer gástrico" postulado por Correa 17 . Una de las características fundamentales de este modelo es que junto con identificar una secuencia progresiva de lesiones, señala también la existencia de progresión/regresión de estas lesiones.

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Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma

Cited by 119 publications

References 42 publications

Identification and analysis of tumour-associated antigens in hepatocellular carcinoma

Identification and analysis of tumour-associated antigens in hepatocellular carcinoma

Plac1 is a tumor‐specific antigen capable of eliciting spontaneous antibody responses in human cancer patients

Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores

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