Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung

Gomes, Ana; Reis-Silva, M.; Alarcão, Ana; Couceiro, Patrícia; Sousa, Vítor; Carvalho, Lina

doi:10.1016/j.rppnen.2013.07.007

Cited by 13 publications

(16 citation statements)

References 16 publications

(7 reference statements)

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“…We also found heterogeneity when studying MHL1 and MSH2 gene methylation [153]. A higher prevalence of the MLH1 gene was identified mainly in squamous cell carcinoma (72%) [153].…”

Section: Doi: 101159/000487440mentioning

confidence: 74%

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Heterogeneity in Lung Cancer

2018

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Lung cancer diagnosis is a challenge since it is also one of the most frequently diagnosed cancers. Diagnostic challenges are deeply related to the development of personalized therapy and molecular and precise histological characterizations of lung cancer. When addressing these features, it is very important to acknowledge the issue of tumour heterogeneity, as it imposes several questions. First of all, lung cancer is a very heterogeneous disease, at a cellular and histological level. Cellular and histological heterogeneity are addressed with emphasis on the diagnosis, pre-neoplastic lesions, and cell origin, trying to contribute to a better knowledge of carcinogenesis. Molecular intra-tumour and inter-tumour heterogeneity are also addressed as temporal heterogeneity. Lung cancer heterogeneity has implications in pathogenesis understanding, diagnosis, selection of tissue for molecular diagnosis, as well as therapeutic decision. The understanding of tumour heterogeneity is crucial and we must be aware of the implications and future developments regarding this field.

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“…We also found heterogeneity when studying MHL1 and MSH2 gene methylation [153]. A higher prevalence of the MLH1 gene was identified mainly in squamous cell carcinoma (72%) [153].…”

Section: Doi: 101159/000487440mentioning

confidence: 74%

“…A higher prevalence of the MLH1 gene was identified mainly in squamous cell carcinoma (72%) [153]. However, no obvious differences were found for MSH2 promoter hypermethylation [153].…”

Section: Doi: 101159/000487440mentioning

confidence: 89%

Heterogeneity in Lung Cancer

2018

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“…35 Other studies have shown the methylation and inhibition of protein expression in gastric, 37 oesophageal 38 and lung cancer. 39 This profile was shown in many cases of oral cancer at early stages and in the later stages of disease in half of the cases, suggesting that methylation of the MLH1 gene promoter is an early event and is maintained during tumour progression. 40,41 In contrast, other authors have shown a low frequency of MLH1 methylation in oral carcinoma.…”

Section: Mlh1mentioning

confidence: 95%

DNA methylation analysis of cancer-related genes in oral epithelial cells of healthy smokers

Oliveira¹,

Silva²,

Mariz³

et al. 2015

Archives of Oral Biology

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“…In the present study, no loss of DNA methylation in oral cells was detected. Other studies have found changes in the DNA methylation of MLH1 gene compared with healthy individuals with individuals with cancer, and hypermethylation was detected in colorectal cancer (Kane et al 1997), gastric cancer (Alves et al 2011), esophagic cancer (Ling et al 2011) and lung cancer (Gomes et al 2014). These studies also found association between hypermethylation and gene repression.…”

Section: Resultsmentioning

confidence: 82%

Age-related Changes in DNA Methylation Status of hTERT Gene Promoter of Oral Epithelial Cells

Bezerra¹,

Costa²,

Freitas³

et al. 2014

Braz. arch. biol. technol.

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The purpose of this study was to investigate the effect of aging on the DNA methylation status of two genes involved in tumorigenesis (telomerase gene hTERT and DNA repair gene-MLH1) and one in metabolism (methylenetetrahydrofolate reductase gene-MTHFR) in oral epithelial cells. DNA methylation analysis was performed by Methylation Sensitive Restriction Enzymes (MSRE) of healthy oral epithelial cells of child (6-10 years, n=21), young (20-25 years, n=19) and elderly (over 60 years, n=25

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Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung

Cited by 13 publications

References 16 publications

Heterogeneity in Lung Cancer

Heterogeneity in Lung Cancer

DNA methylation analysis of cancer-related genes in oral epithelial cells of healthy smokers

Age-related Changes in DNA Methylation Status of hTERT Gene Promoter of Oral Epithelial Cells

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