Promising utilities of growth differentiation factor 15 in cardiovascular diseases

Berezin, Alexander Е.

doi:10.12988/bmgt.2018.811

Cited by 1 publication

(1 citation statement)

References 29 publications

(38 reference statements)

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“…There are many types of congenital heart diseases. Most affect the walls, valves, or blood vessels; some are serious and may need several surgeries and treatment (Berezin et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Role of Growth Differentiation Factor15 in pediatric cardiac patients

Abdelbaseer,

Abdel mawgood,

Hassan

et al. 2024

SVU-International Journal of Medical Sciences

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Background: The most common kind of birth abnormality is a heart problem. When the heart doesn't form properly during pregnancy or birth, it's called a congenital heart defect. CHDs are associated with high rates of mortality and disability. Multiple processes are controlled by the cytokine growth differentiation factor-15 (GDF-15). Because of its continuous overexpression in both CVD and diabetes, GDF-15 is recommended as a biomarker for the existence and severity of both illnesses. In contrast, a large body of research indicates that GDF-15 has a protective role in the regulation of inflammation, endothelial cell function, insulin sensitivity, and weight gain, and is cardioprotective in myocardial infarction (MI).Objectives: Aim of the work is to give highlight on (GDF15) in pediatric cardiac diseases of varies aetiologies. Conclusion:It has been discovered that the cytokine growth differentiation factor-15 (GDF-15) is elevated in a number of clinical states, including hypertension, cardiovascular illness, and oxygen deprivation. GDF-15 is also found to be elevated in HF and PH (pulmonary hypertension). An increased level of GDF-15 is seen in newborns and children with PH-CHD, suggesting its use as a diagnostic biomarker.

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“…There are many types of congenital heart diseases. Most affect the walls, valves, or blood vessels; some are serious and may need several surgeries and treatment (Berezin et al, 2018).…”

Section: Introductionmentioning

confidence: 99%