Promising Use of Selenized Yeast to Develop New Enriched Food: Human Health Implications

González-Salitre, Lourdes; Ad, Román-Gutiérrez; Bautista, Mirandeli; Gm, Rodríguez-Serrano; González-Olivares, Luis Guillermo

doi:10.1080/87559129.2021.1934695

Cited by 14 publications

(6 citation statements)

References 100 publications

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“…In addition, inorganic zinc is unstable and tends to deteriorate during production, transportation, and storage. Inorganic forms of selenium include selenate (Na 2 SeO 4 ) and sodium selenite (Na 2 SeO 3 ) [31], but inorganic selenium may cause genotoxicity in the human body [17]. Due to the low digestibility of inorganic forms of trace elements, to meet the human body's demand, it is necessary to increase the dose, which not only aggravates the toxicity and side effects on human health, but also causes an environmental burden.…”

Section: Inorganic Compoundsmentioning

confidence: 99%

“…Selenium is related to human antioxidant activity and anti-inflammatory and anti-virus properties [16]. Selenium deficiency can induce or increase skeletal muscle and myocardial necrosis, immune function decline, and tumor diseases [17].These micronutrients are important for health, but excessive consumption is toxic [18]. A high level of metal trace elements may cause inflammation in the body, induce an oxidative stress response, and may interfere with the absorption of other trace elements [12].…”

Section: Introduction To Trace Elementsmentioning

confidence: 99%

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Accumulation and Enrichment of Trace Elements by Yeast Cells and Their Applications: A Critical Review

Sun

et al. 2022

Microorganisms

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Maintaining the homeostasis balance of trace elements is crucial for the health of organisms. Human health is threatened by diseases caused by a lack of trace elements. Saccharomyces cerevisiae has a wide and close relationship with human daily life and industrial applications. It can not only be used as fermentation products and single-cell proteins, but also as a trace elements supplement that is widely used in food, feed, and medicine. Trace-element-enriched yeast, viz., chromium-, iron-, zinc-, and selenium-enriched yeast, as an impactful microelements supplement, is more efficient, more environmentally friendly, and safer than its inorganic and organic counterparts. Over the last few decades, genetic engineering has been developing large-scaled genetic re-design and reconstruction in yeast. It is hoped that engineered yeast will include a higher concentration of trace elements. In this review, we compare the common supplement forms of several key trace elements. The mechanisms of detoxification and transport of trace elements in yeast are also reviewed thoroughly. Moreover, genes involved in the transport and detoxification of trace elements are summarized. A feasible way of metabolic engineering transformation of S. cerevisiae to produce trace-element-enriched yeast is examined. In addition, the economy, safety, and environmental protection of the engineered yeast are explored, and the future research direction of yeast enriched in trace elements is discussed.

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Section: Inorganic Compoundsmentioning

confidence: 99%

Section: Introduction To Trace Elementsmentioning

confidence: 99%

Accumulation and Enrichment of Trace Elements by Yeast Cells and Their Applications: A Critical Review

Sun

et al. 2022

Microorganisms

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“…One of its primary functions involves safeguarding essential biological elements like DNA, proteins, and lipids by shielding them against free radicals, which arise as natural byproducts of cellular metabolism [ 2 , 3 ]. A low availability of this element can cause important physiological dysfunctions and can make cultivated fish more susceptible to some stressors, typical of confinement [ 4 ]. Selenium is essential for the functioning of the so-called selenoproteins, such as some seleno-dependent glutathione peroxidase isoforms, an enzyme which plays a crucial antioxidant role in reducing cellular damage generated by free radicals [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, different sources of organic selenium are normally incorporated in animal feed, and their use has been widely accepted in animal nutrition [ 8 ]. The main way it is added to food is largely through the utilization of selenized yeasts [ 4 ] The accumulation of selenium in yeast biomass is carried out by a process of propagation in a medium containing this element, but only at low concentrations. If certain amounts of selenium are exceeded in the medium, it acts as an inhibitor of microbial metabolism, ultimately leading to the death of the yeast [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Selenized yeasts, which predominantly contain seleniomethionine (Se-Met) and other compounds, are the most important sources of organic selenium used in animal production [ 2 ]. However, it has also been proposed that selenium in the form of nanoparticles may have an even greater benefit than solely administering organic or inorganic selenium compounds [ 4 ]. Indeed, beneficial properties have been demonstrated, such as lower toxicity and better yields compared to organic and inorganic selenium, using this approach [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Enhancing Selenium Accumulation in Rhodotorula mucilaginosa Strain 6S Using a Proteomic Approach for Aquafeed Development

Díaz-Navarrete,

Sáez-Arteaga,

Marileo

et al. 2024

Biomolecules

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It is known that selenium (Se) is an essential trace element, important for the growth and other biological functions of fish. One of its most important functions is to contribute to the preservation of certain biological components, such as DNA, proteins, and lipids, providing protection against free radicals resulting from normal metabolism. The objective of this study was to evaluate and optimize selenium accumulation in the native yeast Rhodotorula mucilaginosa 6S. Sodium selenite was evaluated at different concentrations (5–10–15–20–30–40 mg/L). Similarly, the effects of different concentrations of nitrogen sources and pH on cell growth and selenium accumulation in the yeast were analyzed. Subsequently, the best cultivation conditions were scaled up to a 2 L reactor with constant aeration, and the proteome of the yeast cultured with and without sodium selenite was evaluated. The optimal conditions for biomass generation and selenium accumulation were found with ammonium chloride and pH 5.5. Incorporating sodium selenite (30 mg/L) during the exponential phase in the bioreactor after 72 h of cultivation resulted in 10 g/L of biomass, with 0.25 mg total Se/g biomass, composed of 25% proteins, 15% lipids, and 0.850 mg total carotenoids/g biomass. The analysis of the proteomes associated with yeast cultivation with and without selenium revealed a total of 1871 proteins. The results obtained showed that the dynamic changes in the proteome, in response to selenium in the experimental medium, are directly related to catalytic activity and oxidoreductase activity in the yeast. R. mucilaginosa 6S could be an alternative for the generation of selenium-rich biomass with a composition of other nutritional compounds also of interest in aquaculture, such as proteins, lipids, and pigments.

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New biotechnological opportunities for C5 sugars from lignocellulosic materials

Farias

Mélo

Silva

et al. 2022

Bioresource Technology Reports

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Promising Use of Selenized Yeast to Develop New Enriched Food: Human Health Implications

Cited by 14 publications

References 100 publications

Accumulation and Enrichment of Trace Elements by Yeast Cells and Their Applications: A Critical Review

Accumulation and Enrichment of Trace Elements by Yeast Cells and Their Applications: A Critical Review

Enhancing Selenium Accumulation in Rhodotorula mucilaginosa Strain 6S Using a Proteomic Approach for Aquafeed Development

New biotechnological opportunities for C5 sugars from lignocellulosic materials

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