Promising silicones modified with cationic biocides for the development of antimicrobial medical devices

Ghamrawi, Sarah; Bouchara, Jean-Philippe; Tarasyuk, Oksana; Rogalsky, Sergiy; Lyoshina, Lyudmila; Bulko, Olga; Bardeau, Jean‐François

doi:10.1016/j.msec.2017.03.013

Cited by 19 publications

(19 citation statements)

References 76 publications

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“…The antibiofilm/antifouling properties of PA-11 modified with the polymeric biocide PHMG-NS were evaluated using two opportunistic biofilm-forming model strains: the Gram-negative E. coli K12 belonging to the Enterobacteriaceae family [47] and the Gram-positive S. aureus ATCC 25923 [48]. Overall, E. coli has been shown to be more resistant to PHMG-containing biocides than the Gram-positive opportunists, such as methicillin-resistant Staphylococcus aureus [34,35,38,49]. In addition, its enzymes are more stable when in contact with PHMG derivatives [35].…”

Section: Resultsmentioning

confidence: 99%

“…Poorly water-soluble PHMG salts such as PHMG stearate, PHMG sulfanilate, or PHMG dodecylbenzenesulfonate (PHMG-DBS) have been reported as efficient antimicrobial additives for polycaprolactone [34], polylactide [35], polyamides [36,37] and silicones [38]. PHMG-DBS was found to have sufficient thermal stability to be melt processed with PA-11 and PA-12 resins by conventional methods [36,37].…”

Section: Introductionmentioning

confidence: 99%

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Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Moshynets

Bardeau

Tarasyuk

et al. 2019

IJMS

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The choice of efficient antimicrobial additives for polyamide resins is very difficult because of their high processing temperatures of up to 300 °C. In this study, a new, thermally stable polymeric biocide, polyhexamethylene guanidine 2-naphtalenesulfonate (PHMG-NS), was synthesised. According to thermogravimetric analysis, PHMG-NS has a thermal degradation point of 357 °C, confirming its potential use in joint melt processing with polyamide resins. Polyamide 11 (PA-11) films containing 5, 7 and 10 wt% of PHMG-NS were prepared by compression molding and subsequently characterised by FTIR spectroscopy. The surface properties were evaluated both by contact angle, and contactless induction. The incorporation of 10 wt% of PHMG-NS into PA-11 films was found to increase the positive surface charge density by almost two orders of magnitude. PA-11/PHMG-NS composites were found to have a thermal decomposition point at about 400 °C. Mechanical testing showed no change of the tensile strength of polyamide films containing PHMG-NS up to 7 wt%. Antibiofilm activity against the opportunistic bacteria Staphylococcus aureus and Escherichia coli was demonstrated for films containing 7 or 10 wt% of PHMG-NS, through a local biocide effect possibly based on an influence on the bacterial eDNA. The biocide hardly leached from the PA-11 matrix into water, at a rate of less than 1% from its total content for 21 days.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Moshynets

Bardeau

Tarasyuk

et al. 2019

IJMS

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“…Quaternized PEI targets the bacteria cell membrane and eliminates them via a cell lysis mechanism. Due to the positively charged ammonium groups, the polymer gets attracted toward the bacteria via electrostatic interaction . The hydrophobic alkyl groups will be further pulled into the cell as the interaction on the membrane itself will cause the disruption of the lipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

Quarternized Short Polyethylenimine Shows Good Activity against Drug‐Resistant Bacteria

Yew

Chee

Zhang

et al. 2017

Macro Materials & Eng

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The rise in resistant bacteria strains worldwide is proving to be a challenge to the healthcare industry. These “superbugs” are emerging faster than the rate of new antibiotic discovery. This has a heavy impact on medical devices as they are susceptible to biofilm production. Antimicrobial resistance (AMR) causes infections to be difficult to treat, especially postimplantation of a medical device. To prevent bacterial adhesion on devices, various types are coatings are introduced. By binding antibiotics to polymers, an effective adhesive coating on the surface can be created. However, with AMR on the rise, these polymers are losing their efficacy in the application. Another class of antimicrobial polymers with a different mode of mechanism will be explored in this project. Biocidal polymers are effective antimicrobial agents as they rely on the electrostatic interactions between the polymeric charged groups and the charged microbial membrane. Polyethylenimine (PEI) can be modified to achieve a macromolecule containing various charged cationic groups. Quaternizing low‐molecular‐weight PEI with different alkyl groups of short, long, and aromatic groups will give rise to various structural differences. The structure of the quaternized PEI is characterized, and its antimicrobial activity and compatibility are shown to be remarkably improved.

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“…Tested with the method of the international standard (ISO 22196), the results showed that the bacterial counts on the tube were reduced by more than three logarithmic scales. Little leaching of the polymers was detected in water or saline, indicating that the modified layer was quite stable (Ghamrawi et al, 2017). The polylactic acid (PLA) scaffold displayed the bactericidal capability if PHMG was mixed into PLA material.…”

Section: Surface Polymer Blending and Other Methodsmentioning

confidence: 99%

The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices

Qiu

Luo

et al. 2020

Front. Bioeng. Biotechnol.

104

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Medical device contamination caused by microbial pathogens such as bacteria and fungi has posed a severe threat to the patients’ health in hospitals. Due to the increasing resistance of pathogens to antibiotics, the efficacy of traditional antibiotics treatment is gradually decreasing for the infection treatment. Therefore, it is urgent to develop new antibacterial drugs to meet clinical or civilian needs. Antibacterial polymers have attracted the interests of researchers due to their unique bactericidal mechanism and excellent antibacterial effect. This article reviews the mechanism and advantages of antimicrobial polymers and the consideration for their translation. Their applications and advances in medical device surface coating were also reviewed. The information will provide a valuable reference to design and develop antibacterial devices that are resistant to pathogenic infections.

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Promising silicones modified with cationic biocides for the development of antimicrobial medical devices

Cited by 19 publications

References 76 publications

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Quarternized Short Polyethylenimine Shows Good Activity against Drug‐Resistant Bacteria

The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices

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