Promising non-pharmacological therapies in PD: Targeting late stage disease and the role of computer based cognitive training

Weijer, Sjors C.F. van de; Hommel, Adrianus L.A.J.; Bloem, Bastiaan R.; Nonnekes, Jorik; Vries, Nienke M. de

doi:10.1016/j.parkreldis.2017.09.002

Cited by 27 publications

(19 citation statements)

References 24 publications

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“… a Noncomprehensive considerations for gamified cognitive training design (in the field of Parkinson disease); not presented in order of priority and obtained from the wider literature [7,13,15,16,19,20,30,36-39]. …”

Section: Discussionmentioning

confidence: 99%

Do-It-Yourself Gamified Cognitive Training: Viewpoint

Weijer¹,

Kuijf²,

Vries³

et al. 2019

JMIR Serious Games

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Cognitive decline is an important nonmotor symptom in Parkinson disease (PD). Unfortunately, very few treatment options are available. Recent research pointed to small positive effects of nonpharmacological cognitive training in PD. Most of these trainings are performed under supervision and solely computerized versions of (traditional) paper-pencil cognitive training programs, lacking rewarding gamification stimulants that could help to promote adherence. By describing 3 different self-invented ways of cognitive gaming in patients with PD, we aimed to raise awareness for the potential of gamified cognitive training in PD patients. In addition, we hoped to inspire the readers with our case descriptions, highlighting the importance of both personalization and cocreation in the development of games for health. In this viewpoint, we have presented 3 PD patients with different ages, with different disease stages, and from various backgrounds, who all used self-invented cognitive training, including elements of personalization and gamification. To indicate generalization into a larger PD population, the recruitment results from a recent cognitive game trial are added. The presented cases show similarities in terms of awareness of their cognitive decline and the ways this process could potentially be counteracted, by looking for tools to train their cognition. On the basis of the response of the recruitment procedure, there seems to be interest in gamified cognitive training in a larger PD population too. Gamification may add to traditional therapies in terms of personalization and adherence. Positive results have already been found with gamified trainings in other populations, and the cases described here suggest that PD is also an attractive area to develop and test gamified cognitive trainings. However, no results of gamified cognitive trainings in PD have been published to date. This suggests an unmet need in this area and may justify the development of gamified cognitive training and its evaluation, for which our considerations can be used.

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Section: Discussionmentioning

confidence: 99%

Do-It-Yourself Gamified Cognitive Training: Viewpoint

Weijer¹,

Kuijf²,

Vries³

et al. 2019

JMIR Serious Games

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“…Physiotherapy for individuals with severe neurological disorders requires careful assessment of motor, cognitive and emotional impairments. In some cases, patients are not able to perform their exercises without the therapist's assistance (48,49).…”

Section: Telehealth-a Solution For Addressing the Increased Frailty Imentioning

confidence: 99%

Lockdown During COVID-19 and the Increase of Frailty in People With Neurological Conditions

et al. 2020

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Governments around the globe have introduced quarantine, lockdown, and mandatory isolation to slow the transmission of COVID-19. These public health and policy measures aim to protect the public and vulnerable people. This perspective paper argues that the impacts of lockdown (such as social disconnection, reduced exercise, and fewer physiotherapy treatments) may be amplified for people with neurological conditions with subsequent increases in frailty. The paper outlines why this may occur, and explores how adverse impacts for these vulnerable populations may be minimized through strategies such as telehealth, exercise programs, and health policies.

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“…LSPD patients’ assessment and treatment reflect a long list of clinical unmet needs [ 41 ]. Most of the instruments available to assess LSPD patients seem to be partially adequate or mostly inadequate, probably because clinometric properties of such scales have not been specifically tested among LSPD patients, who are difficultly testable due to dementia, behavioral disorders and severe dysarthria.…”

Section: Bottlenecksmentioning

confidence: 99%

“…Equally, non-pharmacological interventions are not adapted to these frail and demented patients. This is one of the reason why, when we extrapolate data of HY 4–5 patients from small trials on multidisciplinary or home-based exercise and strategy training, no improvement is found, for instance, on ADLs or falls [ 41, 42 ]. Additionally, the neuropathology of levodopa unresponsive motor or NMS, remains largely undefined, besides the fact there are no new marketed drugs that properly target those symptoms [ 43 ].…”

Section: Bottlenecksmentioning

confidence: 99%

Challenges and Perspectives in the Management of Late-Stage Parkinson’s Disease

Fabbri

Kauppila

Ferreira

et al. 2020

JPD

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Parkinson’s disease (PD) is a common neurodegenerative disorder, with a continuously increasing prevalence. With improved clinical and therapeutic management of PD, more patients reach later stages of the disease, meaning they may face new clinical problems that were not commonly approached. This gave way to the description of a new PD stage, late-stage PD (LSPD), which is clinically discernible from the advanced-stage one. Therefore, LSPD patients have new and different needs, regarding pharmacological and non pharmacological interventions, including palliative care and multidisciplinary teams. LSPD patients constitute an‘orphan population’, who traditionally was excluded from previous studies, due to its high disability. With this manuscript, we intend to review specific management challenges of LSPD patients, covering this new concept and its clinical features, how to assess these patients, therapeutic recommendations, as well as discussing ongoing research and future perspectives.

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Promising non-pharmacological therapies in PD: Targeting late stage disease and the role of computer based cognitive training

Cited by 27 publications

References 24 publications

Do-It-Yourself Gamified Cognitive Training: Viewpoint

Do-It-Yourself Gamified Cognitive Training: Viewpoint

Lockdown During COVID-19 and the Increase of Frailty in People With Neurological Conditions

Challenges and Perspectives in the Management of Late-Stage Parkinson’s Disease

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